高分辨质谱在环境科学领域应用综述

魏宇; 陈倩羽; 孟维坤; 苏冠勇<sup>*</sup>

引用本文:	魏宇，陈倩羽，孟维坤，苏冠勇.高分辨质谱在环境科学领域应用综述[J].环境监控与预警,2022,14(5):18-26
	WEI Yu, CHEN Qian-yu, MENG Wei-kun, SU Guan-yong.Application of High resolution Mass Spectrometry in the Field of Environmental Science: A Critical Review[J].Environmental Monitoring and Forewarning,2022,14(5):18-26

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高分辨质谱在环境科学领域应用综述
魏宇，陈倩羽，孟维坤，苏冠勇
南京理工大学，环境与生物工程学院，江苏省化工污染控制与资源化高校重点实验室，江苏南京 210094

摘要:

探究复杂环境介质中有机污染物分析检测新方法，建立复杂环境介质中可疑和非目标化合物的快速筛选及确证方案，已成为环境科学领域的研究热点。高分辨质谱仪（HR-MS）具有质量范围宽、扫描速度快、灵敏度高等优点，使其在环境科学领域得到广泛应用。综述了混合高分辨率质谱（Q-TOF/Q Orbitrap）等HR MS技术的特点和工作原理，基于目标化合物分析、可疑化合物分析以及非目标化合物分析这3类研究策略，阐述了HR-MS在环境研究、药品监管及生物代谢物研究等领域的应用现状，进而分析了现阶段HR MS在环境科学领域中的应用局限性和发展前景。

关键词: 环境科学高分辨质谱四极杆飞行时间质谱四极杆静电场轨道阱质谱

DOI：

分类号:X85

基金项目:国家自然科学基金面上基金资助项目（21976088）

Application of High resolution Mass Spectrometry in the Field of Environmental Science: A Critical Review

WEI Yu, CHEN Qian-yu, MENG Wei-kun, SU Guan-yong

Nanjing University of Science & Technology,School of Environmental and Biological Engineering,Nanjing,Jiangsu 210094,China

Abstract:

In recent years, it has become a research hotspot in the field of environmental science to explore new methods for the analysis and detection of organic pollutants in complex environmental media and to establish a rapid screening and confirmation scheme for identifying suspicious and non target compounds in complex environmental matrices. High resolution mass spectrometer (HR-MS) has been widely used in the field of environmental science because of its wider mass range, faster scanning speed and higher sensitivity. This paper summarizes the technical characteristics and working principles of Q-TOF and Q-Orbitrap. Based on the three research strategies of target compound analysis, suspicious compound analysis and non target compound analysis, this paper expounds the application status of HR-MS in the fields of environmental research, drug supervision and metabolite research, and then analyzes the application limitations and development prospects of HR MS in the field of environmental science at this stage.

Key words: Environmental science High resolution mass spectra Q-TOF Q-Orbitrap