Byusing the finite element software ABAQUS we analyse the concrete frame structure with three storeys and three spans,and study the impact location, the impact mass, the initial impact velocity and the influence on the dynamic response of frame structure.The results show that the initial impact velocity hassignificant influence on the impact force peak,while the impact position has little influence on the impact force peak. The initial impact velocity has great influence on maximum deflection and ultimate deflection of beam, while the impact position and the impact mass have little influence; when the side-span beams are impacted, the adjacent beam-column joints suffer serious tensile damage, while when the mid-span beams in the same storey are impacted, the tensile damage in entire frame beam-column joints are relatively slight, but the distribution are relatively wide. With the increase of the impact mass and the initial impact velocity, storey the tensile damage of the whole frame structure is more and more serious, frame beams and beam-column joints are the main energy-consuming locations.