| 2－硝基芴大鼠肝微粒体体外代谢研究 |
| |
| 引用本文： | 沈建伟,王海,徐晓白.2－硝基芴大鼠肝微粒体体外代谢研究[J].环境科学学报,1995(2). |
| |
| 作者姓名： | 沈建伟 王海 徐晓白 |
| |
| 作者单位： | 中国科学院生态环境研究中心 |
| |
| 摘 要： | 初步研究了在通风条件下，经Ａｒｏｃｌｏｒ１２５４诱导的大鼠肝微粒体酶对２－硝基芴的体外代谢。通过液相色谱、气相色谱、质谱、紫外光谱及红外光谱，首次分离和检测出单羟芴和二羟基芴等代谢产物，但未测得明显的硝基还原代谢产物。此外尚有一些谢产物未能定性。高致突变性羟基衍生物的检出，显示出硝基多环芳烃在哺乳动物体内可能存在多种代谢活化途径。为进一步的研究奠定了基础。
|
| 关 键 词： | 2－硝基芴 致突变性 代谢 |
IN VITRO METABOLISM OF ENVIRONMENTAL CARCINOGEN 2- NITRO-FLUORENE BY RAT LIVER S- 9FRACTION |
| |
| Shen Jianwei,Wang Hai,Xu Xiaobai.IN VITRO METABOLISM OF ENVIRONMENTAL CARCINOGEN 2- NITRO-FLUORENE BY RAT LIVER S- 9FRACTION[J].Acta Scientiae Circumstantiae,1995(2). |
| |
| Authors: | Shen Jianwei Wang Hai Xu Xiaobai |
| |
| Abstract: | In vitro metabolism of 2-nitro -fluorene by Aroclor 1254 induced rat liver micro somehas been investigated under ambient atmospheric condition.The metabolites have been iso-lated by reversed phase HPLC and identified by MS,UV,IR,HPLC and GC. Monohy-droxy 1- 2- fluorenes and dihydroxy 1- 2- nitro- fluorene are found at first time in metabolismproducts of 2- nitro-fluorene.Some minor products remained unidentified because of insuffi-cient quantities. The results of this study also confirm the complexity of the metabolic acti-vation pathways of nitro- polycyclic aromatic hydrocarbons. |
| |
| Keywords: | Nitrofluorene mutagenicity metabolism |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《环境科学学报》浏览原始摘要信息 |
|
点击此处可从《环境科学学报》下载全文 |
