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二氧化硫对小鼠不同组织器官的氧化损伤作用
引用本文:孟紫强,张波,秦国华.二氧化硫对小鼠不同组织器官的氧化损伤作用[J].环境科学学报,2001,21(6):768-773.
作者姓名:孟紫强  张波  秦国华
作者单位:山西大学环境医学与毒理学研究所,山西大学生命科学与技术学院,
基金项目:国家自然科学基金资助 (No .30 0 70 6 47),山西省自然科学基金资助
摘    要:对小鼠进行SO2染毒处理,测定吸入SO2后6种脏器(脑、肺、心、肝、脾、肾)的抗氧伦酶活性及抗氧化物质(GSH)和脂质过氧化作用(LPO)的水平。结果表明,(1)SO2吸入引起所有所试脏器抗氧化酶、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性降低,GSH含量下降及脂质过氧化作用升高。(2)SO2对不同脏器引起的氧化损伤程度不同,存在器官差异,尤其以脑、心、肝、肺更为严重。(3)雌、雄有一定差别。由此得出结论:(1)通过过氧自由基引起组织细胞的氧化损伤可能是SO2毒理作用的主要机制;(2)SO2是一种全身性毒物,它可能引起多种组织器官损伤和疾病。

关 键 词:二氧化硫  氧化损伤  脂质过氧化作用  全身性毒物  小鼠  组织器官  大气污染  生物监测
文章编号:0253-2468(2001)-06-0768-06
收稿时间:2001/2/12 0:00:00
修稿时间:2001年2月12日

Oxidation damage of sulfur dioxide on various organs of mice
MENG Ziqiang,ZHANG Bo and QIN Guohua.Oxidation damage of sulfur dioxide on various organs of mice[J].Acta Scientiae Circumstantiae,2001,21(6):768-773.
Authors:MENG Ziqiang  ZHANG Bo and QIN Guohua
Affiliation:Deparrment of life Science, Institute of Envirmental Medicine and Toxicology, Shanxi University, Taiyuan 030006,Deparrment of life Science, Institute of Envirmental Medicine and Toxicology, Shanxi University, Taiyuan 030006 and Deparrment of life Science, Institute of Envirmental Medicine and Toxicology, Shanxi University, Taiyuan 030006
Abstract:The mice were treated by SO2 inhalation for 4 h/day × 7 days, and then activities of Cu,Zn superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), levels of reduced glutathione (GSH) and lipid peroxidation, of various organs (brain, lung, heart, liver, spleen, and kidney) were measured. The results showed that (1) SO2 inhalation decreased the activities of SOD and GSH-Px, also decreased levels of GSH, but increased levels of lipid peroxidation in all mouse organs tested; (2) levels of oxidation damage caused by SO2 were different in various organs, especially oxidation damages of brains, hearts, livers and lungs of mice tested were more serious; (3) Some sex differences were also found. It was suggested that (1) The primary mechanism of toxicological role on mammalian cells by SO2 exposure may be that oxidation damages of lipid and other biomacromolecule are caused by SO2 producing reactive oxygen species; (2) SO2 is a systemic toxin, some damages and diseases of various organs and tissues may be caused by SO2 exposure.
Keywords:sulfur dioxide  oxidation damage  lipid peroxidation  systemic toxin  mouse
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