| 大气PM2.5及高脂饮食对哮喘发病影响的研究进展 |
| |
| 引用本文： | 李志鹏,韩冰,李志刚,赵峰,魏永杰.大气PM2.5及高脂饮食对哮喘发病影响的研究进展[J].环境科学研究,2020,33(9):2169-2174. |
| |
| 作者姓名： | 李志鹏 韩冰 李志刚 赵峰 魏永杰 |
| |
| 作者单位： | 1.中国环境科学研究院, 环境基准与风险评估国家重点实验室, 北京 100012 |
| |
| 基金项目： | 大气重污染成因与治理攻关项目（No.DQGG0305）；国家自然科学基金国际（地区）合作与交流项目NSFC-RS（No.21611130179）；国家自然科学基金项目（No.21477119） |
| |
| 摘 要： | 大气PM2.5暴露与呼吸系统疾病密切相关，高脂饮食是哮喘的诱因之一.近年来，哮喘发病率在我国呈上升趋势.对大气PM2.5、高脂饮食及二者协同作用对哮喘发病的影响进行探讨，为哮喘的干预和治疗提供新思路.总结了PM2.5暴露与高脂饮食对哮喘的影响以及哮喘的发病机制:①颗粒物暴露可引发机体炎症反应，增加哮喘发病风险；②高脂饮食可通过代谢活化机体内免疫相关信号通路，导致炎症发生；③二者均会通过MyD88/TLRs信号通路和Th1/Th2机制对哮喘炎症产生影响.研究显示，PM2.5与高脂饮食对哮喘的作用机制具有一致性，二者对人群的健康影响可能具有协同作用.
|
| 关 键 词： | 哮喘 高脂饮食 PM2.5 Th1/Th2 |
| 收稿时间： | 2020/3/19 0:00:00 |
| 修稿时间： | 2020/5/31 0:00:00 |
Research Progress on the Effects of Atmospheric PM2.5 and High-Fat Diet on the Incidence of Asthma |
| |
| LI Zhipeng,HAN Bing,LI Zhigang,ZHAO Feng,WEI Yongjie.Research Progress on the Effects of Atmospheric PM2.5 and High-Fat Diet on the Incidence of Asthma[J].Research of Environmental Sciences,2020,33(9):2169-2174. |
| |
| Authors: | LI Zhipeng HAN Bing LI Zhigang ZHAO Feng WEI Yongjie |
| |
| Affiliation: | 1.State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China2.Baoding Second Central Hospital, Baoding 072750, China |
| |
| Abstract: | Atmospheric PM2.5 exposure is associated with respiratory diseases, and a high-fat diet is also one of the triggers of asthma. In recent years, the prevalence of asthma has been on the rise in China. Discussion on the effects of atmospheric PM2.5, high-fat diet, and their synergistic effects on the prevalence of asthma may provide a new ideas for the interventional treatment of asthma. The present study summarized the effects of PM2.5 exposure and high-fat diet on asthma and the pathogenesis of asthma, and pointed out: (1) The particulate matter exposure can trigger the inflammatory response in the body and increase the risk of asthma. (2) A high-fat diet can cause inflammation through metabolic activation of immune-related signaling pathways in the body. (3) Both can affect asthma inflammation through the MyD88/TLRs signaling pathway and Th1/Th2. The study reveals: the mechanism of action of PM2.5 and high-fat diet on asthma is consistent, which may have a synergistic effect on human health. |
| |
| Keywords: | asthma high-fat diet PM2 5 Th1/Th2 |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《环境科学研究》浏览原始摘要信息 |
|
点击此处可从《环境科学研究》下载全文 |
|
