Deferoxamine pretreatment inhibits metal neurotoxicity in Caenorhabditis elegans

Neurodegenerative diseases are increasingly common in humans. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of extracellular plaques containing β‐amyloid peptides and neurofibrillary tangles in the brains. Researchers have focused on the elucidation of a correlation between high concentrations of aluminum or iron (in the organism with observed neuropathology). The objective of this study was to evaluate the effects of aluminum and iron on the behavioral parameters (pharyngeal pumping and defecation cycle) of the nematode Caenorhabditis elegans pretreated with deferoxamine (DFX). Acetylcholinesterase (AChE) activity was evaluated as well. DFX is a chelant that is widely used for the treatment of metal toxicity, and it has a high affinity for aluminum and iron. The worms were pretreated with DFX, and then exposed to aluminum and iron. In the absence of DFX, aluminum exposure decreased pharyngeal pumping compared with that in the control group. The defecation cycle of the control was significantly different from that of the worms exposed to aluminum. In contrast, an increased defecation cycle was observed in worms exposed to iron without DFX pretreatment. AChE activity increased in aluminum‐exposed groups that received DFX pretreatment compared with those that did not receive pretreatment. These results suggest that pretreatment with DFX is effective in reducing metal toxicity, particularly with reference to AChE activity, which did not decrease in groups that did not receive DFX pretreatment.     

Effect of long‐term exposure to aluminum and high‐fat diet on NTPDase and 5′‐nucleotidase activities in lymphocytes and platelets of rats

Aluminum is one of the most abundant metals in the earth's crust. Although it shows no known biological function, it is recognized as an adjuvant in vaccines for human and veterinary uses. This study aims to evaluate the role of lifestyle and environment in the promotion of chronic disease. In it, we associated two factors: chronic exposure to aluminum and high‐fat diets. Thus, we aimed to determine whether the association of long‐term exposure to aluminum and high‐fat diets affects the NTPDase and 5′‐nucleotidase activities in the blood platelets and lymphocytes obtained from the mesenteric lymph nodes of young rats. In fact, the ectonucleotidase activities were shown to be upregulated upon exposure to aluminum plus high‐fat diets. As a result, we can suggest that the progressive upregulation of ectonucleotidase activities that we observed could be controlling the extent of inflammation and immune response.     

The impact of monetary liquidity on Chinese aluminum prices

By expanding Frankel and Rose's (2009) theoretical model to consider the interaction of commodity prices with both money liquidity and expectation formation, this paper empirically studies the long-run relationship and short-term dynamics between aluminum prices and money liquidity via Vector autoregressive (VAR) and Impulse Response Function methodologies. Our results show that: (1) a cointegration relationship between money liquidity and Chinese aluminum prices exists, and monetary liquidity positively significantly influences the price over long periods; (2) a structural change has been found during the 2008 Financial Crisis and the change of Chinese monetary policies; and (3) the negative impact of production capacity mechanism on aluminum prices coexists with the positive impact of financial asset returns mechanism, to allow for varied market expectations on aluminum prices within and outside China.     

Social-environmental certification: Sustainable development and competitiveness in the mineral industry of the Brazilian Amazon

This article examines the relationship between increased metal mining and sustainable development in the eastern section of the Amazonian state of Pará in Brazil. Since the early 1980s, mining has grown rapidly in Pará and local mining operations have become global leaders in the production of iron, manganese, bauxite, aluminum, gold, copper and — in the near future — nickel. To stay in tune with global standards, these companies have committed themselves to the principles of sustainability and have obtained certification for both social and environmental aspects of their activities. The article looks into whether such certification is linked to sustainable development of the relatively poor regions where these companies operate. The main findings are that: (1) there is a visible association between certification and improved performance by the companies, but not with the development of nearby areas; and (2) social‐environmental certification processes place more emphasis on ecological variables than on social ones.     

The relationship between daylight and happiness for women in residential districts of Isfahan,Iran

This study explores the relationship between daylight exposure in urban residential units and the mood/happiness of nonworking female residents (housewives) in Isfahan, Iran. A growing body of evidence points to the physiological and psychological benefits of daylight, yet few studies have focused on the relationship between residential daylight and women's mental health. A cross‐sectional study was conducted using two‐stage random cluster sampling of nonworking female occupants of buildings in four residential districts. Mood/happiness was determined using the Oxford Happiness Inventory and the Fordyce Happiness Inventory. Spearman's rank correlation analysis was used to determine the relationship between the variables. A significant relationship was found between residents’ happiness and the amount of daylight in their residential units (Oxford Inventory, r = 0.68, P < 0.05; Fordyce Inventory, r = 0.53, P < 0.05). The findings suggest that features of physical residential environments, such as daylight, may be linked to the happiness of housewives. Persons belonging to various demographic groups who spend the majority of their time indoors (e.g., housewives, children, elderly individuals, and people with disabilities) are most dependent on architecture and environmental design for their well‐being, and therefore, are most affected by design decisions.     

Protective influence of Vitamins against Petroleum-induced free radical toxicity in Rabit

The effect of exposure to crude oil contaminated diet on the blood antioxidant defence system, lipid peroxidation, lipid profile as well as possible protective roles of vitamins E and C were studied in rabbits. Oxidative stress induction by crude oil was indicated by significantly (P < 0.05) increased lipid peroxidation and a non-significant (P < 0.05) decrease in superoxide dismutase and catalase activities. A similar pattern was also detected in the lipid profile: total cholesterol and LDL-cholesterol insignificantly (P < 0.05) increased while HDL-cholesterol and triglyceride significantly decreased relative to rabbits fed normal diet. The reciprocal relationship between HDL-cholesterol and LDL-cholesterol in addition to compromised antioxidant enzymes could predispose exposed animals to coronary heart disease. However, pre-treatment of the diet with vitamins C and E exhibited a protective role on the toxic effect of crude oil on lipid profile, lipid peroxidation as well as antioxidant enzymes. The order of protection was vitamin E + C > vitamin E > vitamin C. These observations seemed to suggest that the protective role of vitamins C and E is synergistic. The protective role of the vitamins is probably time-dependent as significant (P < 0.05) restoration of lipid profile as well as antioxidant enzymes activities to control values was effected after four weeks of exposure. It is therefore suggested that toxic effect of crude oil may be reduced by dietary supplementation of vitamins C and E.     

A paradigm for ecological risk assessment

The 1983 National Academy of Sciences paradigm for conducting human health risk assessment is considered with respect to ecological risk assessment. This four-step paradigm fails to capture key intrinsic differences between the two types of analysis, specifically: identity of risk targets and receptors; identity of the appropriate level of ecological organization at which the risk is expressed; variability of endpoint with respect to risk receptor; and the existence ofrisk cascades through ecological feedback loops. We propose an alternative paradigm that includes a preliminary step,receptor identification, in which chemical partitioning is combined with a conceptual model of the ecosystem to identify appropriate risk targets. In addition, we propose formal inclusion ofendpoint identification and explicit consideration of risk cascades in arelationship assessment in which interactive feedback loops are considered in an iterative process. The proposed paradigm preserves the steps of hazard identification, exposure assessment, dose-response assessment (renamedresponse assessment) and risk characterization, although specific modifications are recommended.     

The role of media exposure, social exposure and biospheric value orientation in the environmental attitude-intention-behavior model in adolescents

This paper explores the hypothesis that contextual environments (media exposure and social exposure) and biospheric value orientation are important antecedents to the attitude-intention-behavior model ( [Ajzen, 2001] and [Ajzen, 2002] ) in the context of environmental psychology. Data for this investigation were obtained from a random sample of 2106 (1073 males and 1025 females) high school students in Hong Kong. A path analysis demonstrates that adolescents’ social exposure and media exposure are associated with biospheric value orientation. The biosperhic value orientation is found to mediate between the contextual variables (media exposure and social exposure) and environmental attitude. This environmental attitude, in turn, mediates the relationship between this value orientation and behavioral intention to act environmentally. Results show that both adolescents’ behavioral intention and degree of social exposure are associated with their environmental behavior. Overall, this article provides empirical support for the proposed path model. The article concludes by presenting theoretical and practical implications for future research in environmental psychology.     

Impact of mercury on the activity pattern of a marker enzyme in a freshwater bivalve

Sessile benthic organisms are universally accepted as bio-indicators of environmental pollution and lysosomal membrane is often the target of injury by xenobiotics resulting in destabilization. Effect of mercury on the activity pattern of the marker enzyme, Acid Phosphatase in the gill and hepatopancreas of the freshwater mussel, Lamellidens corrianus (Lea) at 24, 72, and 168 h, post-exposure discussed. ACP activity was determined as given in Sigma Technical Bulletin (No. 104) and μmol of p-nitrophenol liberated/mg protein/h calculated. The work aimed to study the duration of exposure and concentration of the metal influence, the direction of the response of the enzyme in the two tissues studied and results show that the concentration of the metal as well as the period of exposure do influence the enzyme activity and may have predictive value as a biomarker of impending population changes. Higher concentration of the metal is assumed to have induced stress proteins like metallothioneins.     

The frequency-dependent effect of extremely low-frequency electromagnetic field and mechanical vibration at infrasound frequency on the growth, division and motility of Escherichia coli K-12

The aim of this work was to investigate the frequency-dependent effects of extremely low-frequency electromagnetic field (ELF-EMF) and mechanical vibration at infrasound frequency (MV at IS frequency or MV) on growth and development of Escherichia coli K-12, by using classical microbiological (counting colony forming units), isotopic, spectrophotometric and electronmicroscopic methods. The frequency-dependent effects of MV and ELF-EMF were shown that they could either stimulate or inhibit the growth and the division of microbes depending on the periods following exposure. However, the mechanism through which the MV and ELF-EMF effects affect the bacteria cell is not clear yet. It was suggested that the aqua medium could serve a target through which the biological effect of MV and ELF-EMF on microbes could be realized. To check this hypothesis, the frequency-dependent effects (2, 4, 6, 8, 10 Hz) of both MV and ELF-EMF on the bacterial growth, division and their motility in cases of exposure, the preliminary treated microbes-free medium and microbes containing medium were studied. Both MV and ELF-EMF effect on microbes have frequency and post-exposure period duration-dependent characters. The [ ³ H]-thymidine involving experiments shown that EMF at 4 Hz exposure has pronounced stimulation effect on cell proliferation while 4 Hz MV has inhibition effect. But at 8–10 Hz, the both EMF and MV have inhibitory effects on cell proliferation. It is suggested that 4 and 8 Hz EMF have different biological effects on microbes.     

On‐Site Exposure to Treated Wastewater Effluent Has Subtle Effects on Male Fathead Minnows and Pronounced Effects on Carp

This study tested the hypotheses that (1) exposure to treated Water Reclamation Plant (WRP) effluent will induce biological effects in exposed fish that are consistent with environmental estrogen (EE) exposure; and (2) seasonal differences in effluent composition will moderate biological effects. We conducted seven on‐site exposures using a mobile laboratory. Total estrogenicity of effluents was 10‐ to 20‐fold higher during spring than in fall. Common EEs including steroid estrogens, alkylphenols, and bisphenol‐A were ubiquitous. An unusual spike in total estrogenicity identified a combined sewer overflow event. Fathead minnows (Pimephales promelas) responded to exposure with subtle changes in vitellogenin concentrations and secondary sex characteristics. An opportunity to assess a common carp (Cyprinus carpio) population permanently sustained inside the Stickney WRP revealed pronounced exposure effects, but also the resilience of biological organisms even under long‐term exposure. In contrast to other studies, no histopathological changes were found. The mobile exposure laboratory proved capable of maintaining U.S. Environmental Protection Agency‐recommended exposure conditions while providing flexibility for rapid deployment at multiple sites with minimal operational disruption. Further studies using this platform hold promise to resolve the convoluted interactions between complex effluents and inherent biological complexity.     

Aircraft and road traffic noise exposure and children's mental health

There have been few studies examining noise and psychological disorders in children and the results are equivocal. The objective of this study was to examine exposure–effect relationships between aircraft and road traffic noise exposure and children's mental health. We conducted a cross-national, cross-sectional study assessing 2844 pupils, aged 9–10, from 89 schools around three major airports in the Netherlands, Spain and United Kingdom matched within country for socio-economic position. We selected children on the basis of exposure to external aircraft and road traffic noise exposure. The Strengths and Difficulties Questionnaire (SDQ) assessed child mental health, including emotional problems, conduct disorder, hyperactivity, peer problems and prosocial behaviour. Aircraft noise exposure was significantly associated with an increased score on the hyperactivity subscale (pooled B estimate 0.013 CI 0.007–0.019) after full adjustment. Road traffic noise was significantly associated with lower scores on the conduct problems subscale maintained after full adjustment (pooled B estimate 0.010 95%CI −0.020 to −0.001). There was no association between either aircraft or road traffic noise exposure and the SDQ total score. The hyperactivity results have been found in a previous UK study and may indicate that high aircraft noise exposure exacerbates hyperactivity symptoms in children although this finding requires further replication.     

CAGED FISH AS MONITORS OF POLLUTION: EFFECTS OF CHLORINATED EFFLUENT FROM A WASTEWATER TREATMENT PLANT1

ABSTRACT: Fish confined to cages were used to determine the effects of effluent from a wastewater treatment plant (WWTP). Control fish were kept in cages in an aquaculture pond. Acute effects of the effluent entering the final oxidation pond of the WWTP were determined by confining channel catfish (Ictalurus punctatus) at the pond inlet; the mean total residual chlorine (TRC) concentration was 0.9 mg/l during this exposure. After 8 h, 42 percent of the fish had died and survivors had severe lesions of the skin and gills. During the first two weeks of exposure, channel catfish at the outlet of the final oxidation pond (mean TRC=0.1 mg/l) were predisposed to bacterial infection but lost the parasitic trematodes that were on the gills when the fish were placed in cages. After several weeks, exposed fish had histologic lesions, enlarged livers, and reduced growth. The presence of unidentified carcinogen(s) in the effluent of this WWTP was indicated by papillomas developing on caged black bullheads (Ictalurus melas) and hepatic-enzyme induction in channel catfish. In situ exposure of caged fish was advantageous because storage and pretreatment of water samples were not required, and exposure levels corresponded to those present in the environment. The use of cages for containment of fish during field exposure allowed confinement to the location of interest and convenient sampling of the fish. Unlike wild fish, the caged fish could be compared to control fish with the same pre-exposure history.     

Cadmium: Simulation of environmental control strategies to reduce exposure

The effects of selected environmental control strategies on human dietary and respiratory exposure to environmental cadmium (Cd) have been simulated. For each control strategy, mean Cd dietary and respiratory exposures are presented for a twenty-year simulation period.Human exposures related to cadmium are associated with both process waste disposal and product disposal. Dietary exposure is by far the dominant mechanism for Cd intake. Dietary exposure related to aqueous discharges is primarily a result of municipal sludge landspreading, whereas that associated with emissions to the atmosphere derives mainly from the deposition on cropland of airborne particulates from product incineration. Only relatively small dietary exposure reductions are possible through restrictions on anysingle Cd use. Combinations of waste management and environmental control measures promise greater reductions in dietary and respiratory exposure than those achievable through use restrictions.Work supported by Office of Toxic Substances U.S. Environmental Protection Agency.     

Individual changes in human EEG caused by 450 MHz microwave modulated at 40 and 70 Hz

This study was aimed to investigate the changes in the human electroencephalographic (EEG) signal caused by modulated low-level microwaves. The 450 MHz microwave exposure modulated at 40 Hz and 70 Hz frequencies was applied to a group of 15 volunteers. The field power density at the scalp was 0.16 mW/cm². Ten cycles of the exposure (1 min on and 1 min off) at both modulation frequencies were applied. Analysis of the EEG signal was performed using three different methods: nonlinear method of scaling analysis for length distribution of low variability periods (LDLVP), relative changes in EEG energy (S-parameter) and beta ratio (H-parameter). The analysis revealed significant changes caused by microwave for the whole group (H-parameter method). The exposure caused increase of the EEG beta power (S-parameter method). Statistically significant changes in EEG were detected for four subjects (26.7%) at 40 Hz modulation frequency (LDLVP method).     

A method for determining the phosphorus sorption capacity and amorphous aluminum of aluminum-based drinking water treatment residuals

A high amorphous aluminum or iron oxide content in drinking water treatment residuals (WTRs) can result in a high phosphorus (P) sorption capacity. Therefore, WTR may be used beneficially to adsorb P and reduce P loss to surface or ground water. The strong relationship between acid ammonium oxalate-extractable aluminum (Al(ox)) and Langmuir phosphorus adsorption maximum (P(max)) in WTR could provide a useful tool for determining P(max) without the onus of the multipoint batch equilibrations necessary for the Langmuir model. The objectives of this study were to evaluate and/or modify an acid ammonium oxalate extraction of Al(ox) and the experimental conditions used to generate P adsorption isotherms to strengthen the relationship between Al(ox) and P(max). The oxalate extraction solution to WTR ratio varied from 40:1, 100:1, and 200:1. Batch equilibration conditions were also varied. The WTR particle size was reduced from <2 mm to <150 microm, and batch equilibration was extended from 17 h to 6 d. Increasing the solution to WTR ratio to 100:1 extracted significantly greater Al(ox) at levels of >50 mg Al kg(-1). No additional increase was found at 200:1. Reducing WTR particle size from <2 mm to <150 microm increased P(max) 2.46-fold. Extending the equilibration time from 17 h to 6 d increased P(max) by a mean of 5.83-fold. The resulting empirical regression equation between the optimized Al(ox) and P(max) (r(2) = 0.91, significant at the 0.001 probability level) may provide a tool to estimate the P(max) of Al-based WTR simply by measuring Al(ox). The accurate determination of WTR P(max) and Al(ox) is essential in using WTR effectively to reduce P loss in runoff or to reduce the solubility of P in agricultural soils or organic waste materials (biosolids, manure).     

Interacting effects of pyrethroid and hormone on catalase and protein for toxicity amelioration in the freshwater fish, <Emphasis Type="Italic">Clarias batrachus</Emphasis>

Ameliorating effects of cortisol and T₃ on alphamethrin-dependent changes in the catalase (CAT) and protein profile of the freshwater catfish, Clarias batrachus, were studied. CAT activity and specific activity decreased in the liver, heart, kidney, and intestine after exposure to alphamethrin for 14 days. The administration of cortisol to alphamethrin-exposed fish brought the activity and specific activity of CAT up to their control values. The protein content decreased in different tissues of the fish after exposure to alphamethrin. The administration of T₃ to alphamethrin-exposed fish reduced the protein content to the control value. Therefore, it can be suggested that cortisol and T₃ may be used to ameliorate the toxicological effects of alphamethrin in fish.     

Oxidative enzymes in tissues of the catfish (<Emphasis Type="Italic">Clarias gariepinus</Emphasis>) exposed to varying levels of cadmium

The activities of some oxidative enzymes (aldehyde oxidase, AO, EC 1.2.3.1; xanthine oxidase, XO, EC 1.17.3.2; sulphite oxidase, SO, EC 1.8.3.1; and monoamine oxidase, MO, EC 1.4.3.4) were investigated in the liver, gill, kidney, brain and muscle of a variety of African catfish (Clarias gariepinus) after 7 and 21 days of exposure to 0.1, 0.2 and 0.4 ppm cadmium (Cd) in ambient water. MO, SO and AO activities were significantly (p < 0.05) decreased in a dose-dependent manner in the liver, kidney and gill in the 7-day Cd-exposed fish when compared to control. Conversely, brain MO, AO and SO activities were significantly (p < 0.05) elevated in a dose-dependent manner in the same fishes relative to control. As in the 7-day Cd-exposed fish, the activities of MO, AO and SO were significantly (p < 0.05) decreased in a dose-dependent manner in the gill, kidney and liver of catfish exposed for 21 days. Same is true for XO in these organs after both duration of exposure, except in the liver where no significant change was observed relative to control. The inhibition of these oxidative enzymes in the liver, gill and kidney of catfish may interfere with their biotransformation function, and ultimately the survival of the fish may be compromised.     

Stricter Ozone Ambient Air Quality Standard Has Beneficial Effect on Ponderosa Pine in California

Ambient air quality standards and control strategies are implemented to protect humans and vegetation from adverse effects. We used a process-based tree-growth model (TREGRO) to show that over the past 37 years, changes in O₃ exposure, with accompanying variation in climate, are reflected in changes in the growth of Pinus ponderosa Dougl. ex Laws. in the San Bernardino Mountains near Los Angeles, California, USA. Despite variation in temperature and precipitation over the study period (1963–1999), O₃ exposure consistently reduced simulated tree growth. Simulated growth reductions increased concurrent with increasing O₃ exposure. The maximum growth reduction occurred in 1979. As O₃ exposures decreased during the 1980s and 1990s, effects on growth also decreased. This implies that emission control strategies taken to reduce exposures to attain O₃ standards benefited P. ponderosa growth in the San Bernardino Mountains. This modeling approach provides a powerful tool for solving the difficult problem of evaluating regulatory effectiveness by simulating plant response using long-term climate and air pollution exposure records for a given region.Phone 541 754-4621 Fax 541 754-4799     

Tijuana Childhood Lead Risk Assessment Revisited: Validating a GIS Model with Environmental Data

The objective of this research was to determine the spatial distributions of childhood lead poisoning and soil lead contamination in urban Tijuana. The Bocco–Sanchez model of point-source emissions was evaluated in terms of validity and reliability. We compared the model's predicted vulnerable populations with observed cases of childhood lead poisoning in Tijuana, identified fixed point sources in the field, and analyzed 76 soil samples from 14 sites. The soil lead results were compared to the blood lead analyses performed on Tijuana children whose blood lead levels were ≥10 μg/dL, who reported that they did not use lead-glazed ceramics for cooking or storing food (n = 63). Using GIS, predicted vs observed risk areas were assessed by examining spatial patterns, including the distribution of cases per designated risk area. Chi-square analysis of expected vs observed values did not differ significantly at the p = 0.02 level, showing that the model was strikingly accurate in predicting the distribution of subjects with elevated blood lead. Results reveal that while point sources are significant, other sources of lead exposure are also important. The relative public health risk from exposure to lead in an urban setting may be assessed by distinguishing among sources of exposure and associating concentrations to blood lead levels. The results represent an iterative approach in environmental health research by linking environmental and human biomarker lead concentrations and using these results to validate an environmental model of risk to lead exposure.