Mobile communications and health of population: the risk assessment, social and ethical problems

Today world population lives in a new electromagnetic environment, characterized with (i) around the clock enforcement of chronic exposure of all age and gender groups to a wide range of modulated electromagnetic fields (EMF) from base stations; (ii) daily, repeated from early childhood throughout entire life exposure to EMF RF mobile phone the brain and vestibular receptor apparatus and auditory analyzers, located directly “under the EMF beam” in the inner ear. On the other hand, the world science and epidemiology is missing well-planned and executed research results of prolonged exposure of EMF RF on the brain. International recommendations and domestic guidelines do not include changing conditions of RF EMF on the population: the brain has become a critical organ, and the children entered the risk group. The population continues to actively use the mobile phone. In this situation the problem of assessing the risk of mobile communications has become a social and ethical.     

Occupational risk from static magnetic fields of MRI scanners

The health care staff operating magnetic resonance imaging (MRI) scanners are exposed to static magnetic field of significant spatial heterogenity and high level of flux density—usually existing permanently during the shift. The personnel can also be exposed to pulses of magnetic field of high rate of rise/fall, so-called gradient fields, which exist only during examination of patients. The level of workers’ exposure depends both on the type of the magnet and on the ergonomical characteristic of design of the particular MRI scanner. This paper presents the current state of the art on occupational exposure to static magnetic field health effects, gaps in scientific data, MRI workers’ exposure characteristics, research needs, and suggestions for the exposure assessment protocol for future investigations.     

Worldwide standards on exposure to electromagnetic fields: an overview

Over the last years, a wide debate has developed on the possible health effects of exposure to electromagnetic fields. In-depth research activity was therefore developed by the international scientific community aimed at evaluating the risk associated with exposure to this type of radiation. At the same time, various international institutions began to issue recommendations on exposure limits valid for workers and for the population in the frequency range up to 300 GHz. Most of the recently revised safety standards worldwide are set in terms of internal rates of electromagnetic energy deposition (Specific Absorption Rate) at radiofrequency and microwave frequencies, and of induced electric fields or current densities at lower frequencies up to 10 MHz. At the international level, the most authoritative guidelines have been developed by the International Commission on Non-Ionizing Radiation Protection (ICNIRP); another internationally well recognized standard is that developed by the Institute of Electrical and Electronics Engineers (IEEE) in the USA, adopting the same basic approach of ICNIRP, although with some differences in numerical values. This article is mainly focused on the analysis of different approaches for the protection against electromagnetic fields, and on the rationale of most relevant standards.     

50 Hz alternating extremely low frequency magnetic fields affect excitability,firing and action potential shape through interaction with ionic channels in snail neurones

In spite of growing concern about the influence of magnetic fields on biological systems, the interaction between extremely low frequency magnetic field (ELF magnetic fields) and biological structures at the cellular level remains obscure. The aim of this study was to investigate if 50 Hz magnetic fields could have an effect on the neuronal excitability and firing responses. Under Current-Clamp condition, exposure to 50 Hz ELF magnetic fields at 2 mT or 0.8 mT intensities resulted in an increase in the peak amplitude of action potential and after hyperpolaization potential in a time dependent manner. Both magnetic field intensities decreased also the firing frequency and the duration of action potential. Taken together, these data suggest that 50 Hz ELF magnetic fields at 2 mT or 0.8 mT intensities may change the electrophysiological behavior of neuronal cells and underlying ion channel currents.     

Electromagnetic fields in clinical practice of physical and rehabilitation medicine: a health hazard assessment of personnel

The importance of the assessment of the electromagnetic fields /EMF/ background as a health risk factor for the physiotherapy personnel is discussed in this paper. Wide frequency and amplitude ranges as well as large variety of design prescribed in the rehabilitation program form complicated work conditions. In this paper, we attempt to present and classify this specific work environment, i.e., low intensive EMF background with non homogenous frequency and modulation characteristics, stochastic changes running during day, ground or even underground units’ placement and professional specifics, i.e., chronic EMF expositions, personnel’s trunk and hands exposure, dose-measurement absence, lack of program for prevention and prophylaxis for the assessment of the relatively insufficiently elucidated potential of EMF as a harmful factor for medical staff. Our “Study of the biological effects of the EMF among medical staff from PRM wards—potential of risk reduction”/initialized in 1999/and the original survey card structure are presented in general here first. It has been shown the importance to extend the “native” studies among homogenous professional groups, two of them presented there, as well as the study of the biological effects of EMF in their different aspects, especially taking into account the elevated levels of ionizing and non-ionizing radiation in the environment. This includes the special attention on the exposure of medical staff from PRM units and creation of adequate methods for prevention of unnecessary exposure to these physical factors.     

Analysis of radiation hazards to personnel on marine platforms

The large number of radio frequency (RF) transmitters employed in modern marine platforms requires that they operate in mutual coexistence while posing no danger to operators and equipment despite the limited available physical space. A key to the successful system integration is the control of the electromagnetic environment on the ships’ topsides, which might pose radiation hazards (RADHAZ) to personnel (HERP). HERP are caused by transmitter antenna installations that generate intentional EM radiation in excess of the safe levels in zones of personnel activity. Radiation safety to personnel is achieved when the average radiation power density is below the permissible exposure limits (PEL) for HERP at locations of personnel activity and medical equipment operation. This paper describes the analysis tools and techniques for the evaluation of HERP on marine platforms. The same approaches could be employed in the analysis of land site antenna deployment scenarios.     

Electromagnetic fields and other physical factors around wind power generators (pilot study)

According to the 20/20/20 strategy by European Union for green energy by 2020 priority should be given to the Renewable Energy Sources. The energy generated from the wind has proven to be of interest for several reasons—wind is available, it is a cheap, and virtually inexhaustible source of energy. In this relation in the last years, many wind power stations were built all around the country. They are being located in proximity of populated areas. Their work besides the generation of electricity is connected to emission of physical factors in the environment that could be essential for human health. In order to avoid overexposure to electromagnetic fields, noise, and vibration to the general public minimal safety distance is being determined theoretically for ‘worst case” conditions basing on the technical characteristics of the generators. After the mounting of installations, measurements have to be performed to determine whether the national and European safety limits for the factors of environment are being kept. The paper presents results of measurement of electromagnetic fields, additionally noise and vibration around one of the biggest wind power parks in Bulgaria. The measurements were made in the close proximity of the generators both for the personnel working conditions and for the population in the closest living areas.     

Systemic Effect: A New Approach to Magnetic Field Therapy

Summary Despite of decades of successful worldwide use of magnetic/electromagnetic field therapy, the answer to the question of possible mechanisms of action is still lacking. Scientific reports of successful therapeutic use of magnetic/electromagnetic fields are worldwide; however, our understanding of the underlying mechanism is limited. This paper presents a new hypothesis that therapeutic benefit of magnetic fields might result from effects that originated on the level of important systems in human body. It is known now that the life is an electromagnetic event in aqueous medium. Therefore, an appropriate choice of magnetic and/or electromagnetic field may be expected to initiate systemic changes that result in efficacious effects distant from the point of application. Observations of this phenomenon have been reported in at least two forms: (1) neutralization of the pain experience distant to the point of magnetic field exposure; and, (2) various alterations of T-lymphocytes in response to pain and to magnetic fields. Extrapolating these observations to the level of blood-vessel system, one might hypothesize that a “healthy” cell does not respond as readily to the applied fields as do abnormal cells (which are in a disease or injury state).     

Preliminary studies about effects of ELF and TAMMEF electromagnetic fields on human lymphomonocytes

In our paper we studied the effects of exposure to ELF (extremely low frequency) or musically generated TAMMEF (therapeutic application of musically modulated electromagnetic fields) electromagnetic fields on the tumor necrosis factor alpha (TNF-α) release induced by a lipopolysaccharide (LPS) from cultured human lymphomonocytes of peripheral blood. Lymphomonocytes, isolated from blood donors buffy-coat, were prepared using standard techniques in cell culture flasks, kept in CO₂ incubator, with controlled temperature and humidity for 5 days. Flasks were subjected to an ELF electromagnetic field (100 Hz sinusoidal) or to TAMMEF electromagnetic fields (with intensity, frequency, and wave shape randomly modified in time, so that all possible codes can occur during a single application). The TNF-α release was determined by ELISA test every 24 h for 92 h and the results were evaluated by a non-parametric test. LPS induces a stronger TNF-α release in cultures that were subjected to ELF when compared with cultures subjected to TAMMEF, at each time period of the experimental protocol. These results seem to indicate that TAMMEF is able to induce a complex modulation of LPS-induced TNF-α release, a cytokine with pro inflammatory property whose release during chronic or neoplastic inflammatory diseases has strong negative effects on several organ systems.     

Criticism of the philosophy for development of standards for non-ionizing radiation

The new recommendations of WHO and EC for legislation in Europe and other countries concerning non-ionizing radiation (NIR) health and safety include exposure limits that are very debatable. ICNIRP Guidelines propose exposure limits for electromagnetic fields in the frequency range up to 300 GHz based on short-term exposures and on thermal effects. The new EC proposal for optical and laser safety legislation includes classification of sources of radiation—both lasers and other optical sources, but not requirements for the methodology of classification. On the other hand, many new requirements have been set by the WHO publication “Model Legislation for EMF Protection” concerning the responsibilities in the field of EMF health and safety. Many specialists in the field of developing exposure limits have positions very far away from the proposed of the ICNIRP Guidelines philosophy. The results are different approaches in developing standards and exposure limits, and differences more than 100 times in maximal permissible levels. We, the Bulgarian Program Committee on NIR, try to organize working groups and discuss different philosophy for developing exposure limits for more than 10 years. This paper exposes our position in this area.     

The similar effects of low-dose ionizing radiation and non-ionizing radiation from background environmental levels of exposure

The meltdown and release of radioactivity (ionizing radiation) from four damaged nuclear reactors at the Fukushima Nuclear Facility in Japan in March 2011 continues to contaminate air and ocean water even 1 year later. Chronic exposure to low-dose ionizing radiation will occur over large populations well into the future. This has caused grave concern among researchers and the public over the very long period of time expected for decommissioning alone (current estimate from official sources is 30–40 years based on TEPCO in Mid-and long-term roadmap towards the decommissioning of Fukushima Daiichi nuclear power units 1–4, 2011) and the presumed adverse effects of chronic, low-dose ionizing radiation on children, adults and the environment. Ultimately, radioactive materials from Fukushima will circulate for many years, making health impacts a predictable concern for many generations (Yasunari et al. in PNAS 108(49):19530–19534, 2011). There is long-standing scientific evidence to suggest that low-dose ionizing radiation (LD-IR) and low-intensity non-ionizing electromagnetic radiation (LI-NIER) in the form of extremely low-frequency electromagnetic fields and radiofrequency radiation (RFR) share similar biological effects. Public health implications are significant for reconstruction efforts to rebuild in post-Fukushima Japan. It is relevant to identify and reduce exposure pathways for chronic, low-dose ionizing radiation in post-Fukushima Japan given current scientific knowledge. Intentional planning, rather than conventional planning, is needed to reduce concomitant chronic low-intensity exposure to non-ionizing radiation. These are reasonably well-established risks to health in the scientific literature, as evidenced by their classification by World Health Organization International Agency for Research on Cancer as Possible Human Carcinogens. Reducing preventable, adverse health exposures in the newly rebuilt environment to both LD-IR and LI-NIER is an achievable goal for Japan. Recovery and reconstruction efforts in Japan to restore the communications and energy infrastructure, in particular, should pursue strategies for reduction and/or prevention of both kinds of exposures. The design life of buildings replaced today is probably 35–50 years into the future. Cumulative health risks may be somewhat mitigated if the double exposure (to both chronic low-dose IR from the Fukushima reactors and LI-NIER [EMF and RFR] in new buildings and infrastructure) can be dealt with effectively in early planning and design in Japan’s reconstruction.     

Nonthermal GSM RF and ELF EMF effects upon rat BBB permeability

Since the late 1980s, our group has examined the effects of radiofrequency electromagnetic fields (RF-EMF), including pulse-modulated waves of the type emitted by mobile phones, upon the blood?Cbrain barrier. In more than 2,000 rats, we have repeatedly demonstrated a passage of the rats?? own albumin from the blood through the brain capillaries into the surrounding brain parenchyma at SAR values down to 0.1mW/kg. In most of these experiments, the animals were exposed in TEM-cells, ventilated by an external electrical fan at 50 Hz. In the present study, we examined whether the extremely low frequency (ELF) magnetic fields from the fan (50 Hz, 0.3?C1.5 ??T) might add to the RF effect. Sixty-four rats were divided into 4 groups: RF only, ELF only and RF + ELF exposure plus a sham group. The GSM-900 MHz RF exposure was at the very low, nonthermal, average whole-body SAR level 0.4 mW/kg. Demonstration of the normally occurring albumin extravasation in the basal hypothalamus is our inbuilt control proving that the staining is reliable. Two full series of staining of the whole material gave negative results for hypothalamus. Not until we changed to avidin, biotin, and antibodies from a third supplier, we received an acceptable staining. Twenty-five percent of the RF animals had a pathological albumin leakage, while the ELF and RF + ELF groups with three and two pathological findings, respectively, were not significantly different from the control group. We conclude that the use of external fans has had no major influence upon the result.     

Exposure to radiation from global system for mobile communications at 1,800 MHz significantly changes gene expression in rat hippocampus and cortex

We have earlier shown that radio frequency electromagnetic fields can cause significant leakage of albumin through the blood–brain barrier of exposed rats as compared to non-exposed rats, and also significant neuronal damage in rat brains several weeks after a 2 h exposure to a mobile phone, at 915 MHz with a global system for mobile communications (GSM) frequency modulation, at whole-body specific absorption rate values (SAR) of 200, 20, 2, and 0.2 mW/kg. We have now studied whether 6 h of exposure to the radiation from a GSM mobile test phone at 1,800 MHz (at a whole-body SAR-value of 13 mW/kg, corresponding to a brain SAR-value of 30 mW/kg) has an effect upon the gene expression pattern in rat brain cortex and hippocampus—areas where we have observed albumin leakage from capillaries into neurons and neuronal damage. Microarray analysis of 31,099 rat genes, including splicing variants, was performed in cortex and hippocampus of 8 Fischer 344 rats, 4 animals exposed to global system for mobile communications electromagnetic fields for 6 h in an anechoic chamber, one rat at a time, and 4 controls kept as long in the same anechoic chamber without exposure, also in this case one rat at a time. Gene ontology analysis (using the gene ontology categories biological processes, molecular functions, and cell components) of the differentially expressed genes of the exposed animals versus the control group revealed the following highly significant altered gene categories in both cortex and hippocampus: extracellular region, signal transducer activity, intrinsic to membrane, and integral to membrane. The fact that most of these categories are connected with membrane functions may have a relation to our earlier observation of albumin transport through brain capillaries.     

Signal processing and wavelet analysis of simultaneously registered blood pressure and laser Doppler flow signals during extremely low frequency electromagnetic field exposure in humans in vivo

Regulation of microcirculation and other physiological processes have strong non-linear character and involves complex of different processes, every process with own hierarchy in time and different frequencies. Traditional Fourier analysis does not provide sufficient power and resolution to elucidate characteristic of low vasomotor frequencies. Therefore, we apply a Time–frequency (wavelet) analysis on the signal obtained by Laser Doppler flow meter (LDF) at 25 healthy volunteers, exposed at the same time to low frequency electromagnetic fields, used for physiotherapy. Signal processing include Matlab based algorithms for digital signal processing (DSP) and Matlab Spectral analysis toolbox of simultaneous registered variations in Blood Pressure (BP), Laser Doppler Flow (LDF), and Intravital microscopy (IVM). It provides useful information about regulatory mechanisms and vegetative nervous system regulation of peripheral blood flow. Continuous changes in blood pressure variations and perfusion of extremities were measured prior and after 10, 20, and 30 min ELF-EMF (10, 16, 20, and 30 mT), exposure. After wavelet analysis of the blood flow signals and vasomotion changes signals, several frequency bands were distinguished: 0.0095–0.02 Hz; (α), 0.02–0.06 Hz; (β), 0.06–0.15 Hz; (γ), 0.15–0.4 Hz; (δ), and 0.4–1 Hz; (θ) for LDF data and 0.0095–0.4 Hz; (α), 0.4–0.75 Hz; (β), 0.75–0.9 Hz; (γ), 0.9–1.2 Hz; (δ), and 1.2–2 Hz; (θ) for IVM data. In this study, overlapping of some frequency bands between IVM and LDF data were found. Overlapping of the frequency bands has two ways of interpretation, one related with similarity of the structures and tissues and other related with output of ELF-EMF stimulation. We used also correlation and cross-correlation analysis to compare non-invasive (BP measurements and LDF) data, with invasive intravital microscopy (IVM) data (obtained on animals in vivo), during ELF-EMF stimulation. IVM data were used as a reference value, for certain information of possible mechanisms of biological response at the tissue and blood vessel level after ELF-EMF exposure with frequency in the range from 10 to 50 Hz and magnetic flux density of 20 mT. Comparative analysis of IVM and LDF, frequency bands show that they have statistical significant changes after ELF-EMF stimulation. Five subintervals were confirmed (α-, β-, γ-, δ-, and θ). The findings indicate that local ELF-EMF exposure at the constant temperature of the media increases skin blood flow at the upper extremities which have a contribution to the α-frequency band at IVM.     

Practical aspects of occupational EMF exposure assessment

Electromagnetic fields exposure assessment methodology is briefly presented. The basic problems defined for the practical use of electromagnetic fields measurements and numerical calculations carried out for workers exposure assessment in real occupational situations are discussed. The examples of data from real workplace are presented, focusing: spatial distribution of electromagnetic fields affecting worker’s body, complex characteristics of the frequency content, workers activities/moving in the workplace, field impedance, etc. The situation when the use of calculations is required is discussed. The basic requirements for workers exposure assessment protocols are presented. The possible range of the use of internal and external measures of exposure level is also discussed.     

Biological effect on blood cerebrospinal fluid barrier due to radio frequency electromagnetic fields exposure of the rat brain in vivo

Concerns on health effects of radiofrequency (RF) signals have been discussed. Particularly, the effect on the central nerve system is one of main interest among the general public. So far, there are lots of studies regarding the RF effect on the Blood Brain Barrier (BBB), but no study of the RF effect on the Blood Cerebrospinal fluid Barrier (BCB). In this study we explored the effect on BCB function by radiofrequency electromagnetic fields (RF-EMF) exposure. To attain this purpose, we set about to make a real-time measuring system for BCB function using a micro-perfusion method and examined the short time exposure experiment using rats. Our data suggested the 30 min single exposure of 1.5 GHz RF-EMF at the brain average SARs of 9.5 W/kg for adult and 10.4 W/kg for juvenile, did not affect BCB function in rats under the experimental conditions.     

How living systems recognize applied electromagnetic fields

Natural and man-made magnetic and electromagnetic fields are important factors in the contemporary life. The paper discusses the role of environmental magnetic and electromagnetic fields in origin and evolution of life. A brief review of the characteristics of Earth magnetic field, Earth magnetosphere, and their role as a shield for cosmic radiation follows. The role of endogenous and exogenous magnetic fields is discussed in respect of the clarification of the potential hazard and benefit of electromagnetic fields. The second part of the paper discusses the mechanisms of detection and response to exogenous electromagnetic fields, as well as threshold versus window hypothesis for mechanisms of interactions. Finally, the necessity of accurate dosimetry at the target site and the importance of relevant research and clinical protocols in studying biological responses are pointed out.     

An investigation of the effects from the user’s hand and head over received level and adaptive power control of a GSM mobile phone in typical operating environment

Current evolution of wireless personal communications has necessitated a comprehensive understanding of electromagnetic interactions between handset antennas and nearby human body. In this work the handset–human body interactions were evaluated in various configurations (with and without user’s hand; with and without user’s head, and combinations of them) in order to obtain statistical averages of the overall performance for system link evaluations. The measurements were performed using the random-field measurement (RFM) method, and thus the acquisition of large amounts of data about human–mobile phone interactions in typical operating environment with measured the received RF signal strength (RXLEV), and the output power level (TXLEV) on mobile station. The RXLEV and the TXLEV was measured over the air interface in the networks on two Bulgarian GSM mobile operators (Mtel and Vivatel). Both uplink and downlink measurements were performed in urban area in three cities. Each measurements were carried out in a building included both line-of-sight and non-line-of-sight propagation of the electromagnetic waves between mobile station and base station. The results showed that the user’s hand and head induces more significant changes on the received RF signal strength in case when broadcast control channel (BCCH) levels are up to −60 dBm. Also the alterations of receiving RF signal strength and output power level of the MS are influence stronger from the larger size of the hand and head of user. The influence from presence of the head and hand of the subscriber in talk position over the alteration of the receiving RF signal strength is in boundaries from 14.21 dBm to 19.1 dBm (man) and from 8.5 dBm to 12.05 dBm (woman). The presence of the user’s hand and head increased the output power level of mobile station with 12 dBm to 14 dBm (man) and with 10 dBm to 12 dBm (woman) compare to output power level without user’s hand and head.     

EMF risk for operators mounting,adjusting and maintaining base stations

In the recent years concerns whether exposure to electromagnetic fields (EMF) from base station antennae can cause adverse health effects are grown. Great attention is paid on risk of EMF exposure to people living in a close proximity of base stations. In this issue, a point of interest is the personnel mounting, adjusting and maintaining base stations. Their working tasks require stay in high EMF levels’ conditions. There are only few studies concerning this specific occupational group. The results from our previous investigation (COST 281—Graz, 2006) show that in many cases on performing some specific tasks operators are overexposed according to our national legislation, and ICNIRP guidelines. Here, we present an extended study covering more base stations and more precise scenario for performed tasks and working positions. Results of exposure assessment are presented. They include energetic load calculations on the basis of Bulgarian national legislation, and the corresponding SAR values. Data are used to determine permissible time duration for each particular work operation and served as a base for limiting the exposure and proposal for protective measures for the personnel.     

EMF effects on microcirculatory system

Authors review the importance of studying the effects of electromagnetic fields (EMF) on microcirculatory system, especially in respect of possibility that vasculature may have direct and indirect role in interaction of static magnetic fields (SMF). We outline the physiological importance of microcirculation and relatively new methods of evaluation technique in vivo and explain in details the local and/or whole body exposure effects of SMF with␣range of 0.3–180 mT, power frequency EMF with range of 0.1–30 mT and microwaves at 1.5 GHz with range 0.08–8 W/kg brain average specific absorption rate (SAR) on microcirculatory systems in different tissues in experimental animals.