Endocrine disrupting pesticides: implications for risk assessment

Endocrine disrupting (ED) chemicals are compounds that alter the normal functioning of the endocrine system, potentially causing disease or deformity in organisms and their offspring. Pesticides are used widely to kill unwanted organisms in crops, public areas, homes and gardens and medicinally to kill parasites. Many are proven or suspected to be EDs. Ancient physiological similarities between different vertebrate groups suggest that disorders observed in wildlife may indicate risks to humans. This makes accurate risk assessment and effective legislation difficult. In this paper, the hazardous properties of pesticides which are known to have ED properties are reviewed in order to assess the implications for risk assessment. As well as data on sources of exposure in the United Kingdom (UK) an assessment of the evidence on the health effects of ED pesticides is also included. In total, 127 have been identified from the literature and their effects and modes of action are listed in this paper. Using the UK as a case study, the types and quantities of pesticides used, and their methods of application are assessed, along with their potential pathways to humans. In the UK reliable data are available only for agricultural use, so non-agricultural routes of pesticide exposure have been poorly quantified. The exposure of people resident in or visiting rural areas could also have been grossly under-estimated. Material links between ED pesticide use and specific illnesses or deformities are complicated by the multifactorial nature of disease, which can be affected by factors such as diet. Despite these difficulties, a large body of evidence has accumulated linking specific conditions to ED pesticides in wildlife and humans. A more precautionary approach to the use of ED pesticides, especially for non-essential purposes is proposed.     

Environmental risk assessment of metals: tools for incorporating bioavailability

In this paper, some of the main processes and parameters which affect metal bioavailability and toxicity in the aquatic environment and its implications for metal risk assessment procedures will be discussed. It has become clear that, besides chemical processes (speciation, complexation), attention should also be given to physiological aspects for predicting metal toxicity. The development of biotic ligand models (BLMs), which combine speciation models with more biologically oriented models (e.g. GSIM), has offered an answer to this need. The various BLMs which have been developed and/or refined for a number of metals (e.g. Cu, Ag, Zn) and species (algae, crustaceans, fish) are discussed here. Finally, the potential of the BLM approach is illustrated through a theoretical exercise in which chronic zinc toxicity to Daphnia magna is predicted in three regions, taking the physico-chemical characteristics of these areas into account.     

Gender and community-oriented wildlife conservation: views from project supervisors in India

Many international agreements, such as the 1992 UN Convention on Biological Diversity, posit that successful community-oriented (community-based) wildlife conservation depends on partnerships with stakeholders of different class, ethnicity, and gender. Gender is of particular interest because it often relates to environmental use, attitudes, and knowledge and operates across other key categories. This study uses fieldwork, interviews, and a survey of 52 project heads in India to address two research questions: (1) How are gender issues viewed by supervisors of community-based wildlife conservation projects, in relation to their work? (2) What types of resources would be most useful to project heads seeking to promote gender equity through their conservation work? The results suggest that while there is widespread support for integrating gender equity issues into community-oriented wildlife conservation, many believe that gender may be a potentially distracting and secondary issue. Several reasons for the variation in views were identified including the following: the dearth of relevant empirical research about gender issues in wildlife conservation; ambiguities about the concept of gender itself; and a lack of opportunities to critically discuss the role of gender equity issues for conservation. These factors may contribute to a disconnection between international rhetoric and on-the-ground practice as it relates to gender and community-oriented wildlife conservation. Increased opportunities for professional capacity building among project supervisors and staff members, coupled with increased collaboration between social and natural scientists, will be important for strengthening the links between international conservation policy and on-the-ground practice.     

Regional risk assessment for contaminated sites part 1: vulnerability assessment by multicriteria decision analysis

As highlighted in the EU Soil Communication, local contamination is one of the main soil threats and it is often related to present and past industrial activities which left a legacy of a high number of contaminated sites in Europe. These contaminated sites can be harmful to many different receptors according to their sensitivity/susceptibility to contamination, and specific vulnerability evaluations are needed in order to manage this widely spread environmental issue. In this paper a novel comprehensive vulnerability assessment framework to assess regional receptor susceptibility to contaminated site is presented. The developed methodology, which combines multi criteria decision analysis (MCDA) techniques and spatial analysis, can be applied to different receptors recognized as relevant for regional assessment. In order to characterize each receptor, picked parameters significant for the estimation of the vulnerability to contaminated sites have been selected, normalized and aggregated by means of multi criteria decision analysis (MCDA) techniques. The developed MCDA methodology, based on the Choquet integral, allows to include expert judgments for the elicitation of synergic and conflicting effects between involved criteria and is applied to all the geographical objects representing the identified receptors. To test the potential of the vulnerability methodology, it has been applied to a specific case study area in the upper Silesia region of Poland where it proved to be reliable and consistent with the environmental experts' expected results. The vulnerability assessment results indicate that groundwater is the most vulnerable receptor characterized by a wide area with vulnerability scores belonging to the highest vulnerability class. As far as the other receptors are concerned, human health and surface water are characterized by quite homogeneous vulnerability scores falling in the medium-high vulnerability classes, while protected areas resulted to be the less vulnerable receptor with only one protected area falling in the medium vulnerability class. The vulnerability assessment results will support the regional risk assessment for the ranking of potentially contaminated sites at regional scale.     

Chemical plant risk assessment: Uncertainties and development needs

A brief review is given covering the development of major hazards risk assessment since the Flixborough disaster of 1974, with special reference to the introduction of new regulations. The importance of risk assessment in the management of major hazards is discussed by reference to the Canvey Island studies, and it is suggested that the problem of uncertainties in the estimation of risks by analysis has not been adequately treated. Examples are given to illustrate the magnitude of such uncertainties in the consequence modelling of accidental releases from a chemical plant. In addition to suggested development needs in risk analysis techniques, topics are suggested which call for development in the evaluation and management of risks.     

Environmental biodosimetry: a biologically relevant tool for ecological risk assessment and biomonitoring

Biodosimetry, the estimation of received doses by determining the frequency of radiation-induced chromosome aberrations, is widely applied in humans acutely exposed as a result of accidents or for clinical purposes, but biodosimetric techniques have not been utilized in organisms chronically exposed to radionuclides in contaminated environments. The application of biodosimetry to environmental exposure scenarios could greatly improve the accuracy, and reduce the uncertainties, of ecological risk assessments and biomonitoring studies, because no assumptions are required regarding external exposure rates and the movement of organisms into and out of contaminated areas. Furthermore, unlike residue analyses of environmental media, environmental biodosimetry provides a genetically relevant biomarker of cumulative lifetime exposure. Symmetrical chromosome translocations can impact reproductive success, and could therefore prove to be ecologically relevant as well. We describe our experience in studying aberrations in the yellow-bellied slider turtle as an example of environmental biodosimetry.     

Groundwater contamination by microbiological and chemical substances released from hospital wastewater: Health risk assessment for drinking water consumers

Contamination of natural aquatic ecosystems by hospital wastewater is a major environmental and human health issue. Disinfectants, pharmaceuticals, radionuclides and solvents are widely used in hospitals for medical purposes and research. After application, some of these substances combine with hospital effluents and, in industrialised countries, reach the municipal sewer network. In certain developing countries, hospitals usually discharge their wastewater into septic tanks equipped with diffusion wells. The discharge of chemical compounds from hospital activities into the natural environment can lead to the pollution of water resources and risks for human health. The aim of this article is to present: (i) the steps of a procedure intended to evaluate risks to human health linked to hospital effluents discharged into a septic tank equipped with a diffusion well; and (ii) the results of its application on the effluents of a hospital in Port-au-Prince. The procedure is based on a scenario that describes the discharge of hospital effluents, via septic tanks, into a karstic formation where water resources are used for human consumption. COD, Chloroform, dichlomethane, dibromochloromethane, dichlorobromomethane and bromoform contents were measured. Furthermore, the presence of heavy metals (chrome, nickel and lead) and faecal coliforms were studied. Maximum concentrations were 700 NPP/100 ml for faecal coliforms and 112 mg/L for COD. A risk of infection of 10^? 5 infection per year was calculated. Major chemical risks, particularly for children, relating to Pb(II), Cr(III), Cr(VI) and Ni(II) contained in the ground water were also characterised. Certain aspects of the scenario studied require improvement, especially those relating to the characterisation of drugs in groundwater and the detection of other microbiological indicators such as protozoa, enterococcus and viruses.     

Health risk assessment for uranium in Korean groundwater

We analyzed the radiological and chemical risks of uranium in groundwater. The total sample number over 4 years was 498. There were several use patterns of groundwater in Korea, but we considered the risk only for drinking water. The geometric mean of uranium concentration in 10 areas in Korea was 0.17 microg x l(-1). The excess cancer risks were in the 10(-7) level in the radiological risk aspect and the hazard quotient was 0.005 in the chemical risk aspect. Therefore, we could conclude that an adverse health risk is unlikely to be posed due to exposure to uranium. However, the concentration of uranium must be monitored periodically and adequate action taken in the few and small areas that contain high uranium levels in groundwater.     

Probabilistic risk assessment for long-range atmospheric transport of radionuclides

A simplified means of probabilistic risk assessment (PRA) for long-range atmospheric transport based on a K-diffusion model is presented. In a case study, model parameters are estimated by comparing with the results of long-range atmospheric dispersion model calculations using one-year numerical weather prediction model data. It is found that the estimated ensemble mean provides a reasonable first approximation to the total dry and wet deposition from the one-year continuous release.     

The bioavailability of selenium and risk assessment for human selenium poisoning in high-Se areas,China

Enshi prefecture of Hubei Province is well known for human selenium (Se) poisoning in the early 1960s in China. Sporadic cases of Se poisoning in livestocks are still being found. In this study, Se levels in water, cropland soils and various crops from high-Se areas of Enshi were measured to investigate the distribution and bioavailability of Se in the environments, as well as probable daily intake (PDI) of Se for local residents. The total Se in surface water ranged from 2.0 to 519.3 μg/L with a geometric mean of 46.0 ± 127.8 μg/L (n = 48), 70.5–99.5% of which was present in the form of Se(VI). The soil Se concentration varied from 2.89 to 87.3 μg/g with a geometric mean of 9.36 ± 18.6 μg/g (n = 45), and most of Se was associated with organic matter (OM-Se). The total Se in rice, corn, and vegetable samples were 2.11 ± 2.87 μg/g (n = 21), 3.76 ± 11.6 μg/g (n = 16), and 2.09 ± 3.38 μg/g (n = 25), respectively. Stream water Se is likely leached from carbonaceous shale and mine wastes, leading to Se accumulation in paddy soils. OM-Se may play an important role in Se uptake by rice plant in high-Se area of Enshi.The PDI of Se is approximately 2144 μg/day, and Se concentration in blood is estimated at about 3248 μg/L, posing a potential chronic Se poisoning risk to local residents. Cereal consumption (48.5%) makes a great contribution to human daily Se intake, followed by vegetables (36.6%), meats (8.5%), and drinking water (6.4%). However, when assessing health risk on human in high-Se areas, the contribution of drinking water to daily Se intake cannot be ignored due to high Se content and dominant Se(VI) species. Local inhabitants should be advised not to grow crops in high-Se lands or irrigate using high-Se water. If possible, they should drink pipe water and consume foods mixed with those from outside the high-Se areas.     

Regional risk assessment for contaminated sites part 2: ranking of potentially contaminated sites

Environmental risks are traditionally assessed and presented in non spatial ways although the heterogeneity of the contaminants spatial distributions, the spatial positions and relations between receptors and stressors, as well as the spatial distribution of the variables involved in the risk assessment, strongly influence exposure estimations and hence risks. Taking into account spatial variability is increasingly being recognized as a further and essential step in sound exposure and risk assessment. To address this issue an innovative methodology which integrates spatial analysis and a relative risk approach was developed. The purpose of this methodology is to prioritize sites at regional scale where a preliminary site investigation may be required. The methodology aimed at supporting the inventory of contaminated sites was implemented within the spatial decision support sYstem for Regional rIsk Assessment of DEgraded land, SYRIADE, and was applied to the case-study of the Upper Silesia region (Poland). The developed methodology and tool are both flexible and easy to adapt to different regional contexts, allowing the user to introduce the regional relevant parameters identified on the basis of user expertise and regional data availability. Moreover, the used GIS functionalities, integrated with mathematical approaches, allow to take into consideration, all at once, the multiplicity of sources and impacted receptors within the region of concern, to assess the risks posed by all contaminated sites in the region and, finally, to provide a risk-based ranking of the potentially contaminated sites.     

The estimation of influencing factors for carbon emissions based on EKC hypothesis and STIRPAT model: Evidence from top 10 countries

Environment, Development and Sustainability - Global climate change due to greenhouse gas emissions has observable impacts on environment. Among the GHG emissions, carbon dioxide is the primary...     

Probabilistic mercury multimedia exposure assessment in small children and risk assessment

ObjectivesEmissions of mercury in the environment have been decreasing for several years. However, mercury species are still found in different media (food, water, air and breast-milk). Due to mercury toxicity and typical behaviour in children, we have conducted a mercury exposure assessment in French babies, and small children aged 0 to 36 months.MethodConsumption and mercury concentration data were chosen for the exposure assessment. The Monte Carlo technique has been used to calculate the weekly exposure dose in order to integrate inter-individual variability and parameter uncertainty. Exposure values have been compared to toxicological reference values for health risk assessment.ResultsInorganic mercury median exposure levels ranged from 0.160 to 1.649 μg/kg of body weight per week (95th percentile (P95): 0.298–2.027 µg/kg bw/week); elemental mercury median exposure level in children was 0.11 ng/kg bw/week (P95: 28 ng/kg bw/week); and methylmercury median exposure level ranged from 0.247 to 0.273 µg/kg bw/week (P95: 0.425–0.463 µg/kg bw/week). Only elemental mercury by inhalation route (indoor air) and methylmercury by ingestion (fish and breast-milk) seem to lead to a health risk in small children.ConclusionsThese results confirm the importance of assessing total mercury concentration in media like breast-milk, indoor air and dust and methylmercury level in food, other than fish and seafood. In this way, informed monitoring plan and risk assessment in an at-risk sub-population can be set.     

Environmental risk assessment and the intrusion of bias

The concept of managing the environment and any associated human health impacts by means of such science-based tools as toxicological evaluation, risk assessment, and economic appraisal has become widely accepted in professional circles. These increasingly complex methodologies have not won universal support, however, even among the technically minded, and the wider public has in many cases remained sceptical. The public's seeming lack of enthusiasm has frequently been assigned to ignorance of science, irrationality even, and some attempts have been made to ameliorate the situation by means of education, though with little evidence of success. However, this review advances an alternative explanation, namely, that the disenchantment has more to do with procedural than technical matters. Many issues, although treated with technical risk assessment appear to have forced themselves onto the agenda because of factors only passingly connected with risk, and which are more related to the intrusion of disputed values and other sources of bias. This paper also notes that the intervention of bias in decision making is rife, and is found as much in professional as in public approaches. This need not itself be a problem, providing it is recognised and openly expressed. However, there remains a need for much greater circumspection and frankness by professions about the status of their art, and a determined effort if the full social benefits of environmental risk assessment (ERA) are to be realised.     

Health risk assessment of emissions of dioxins and furans from a municipal waste incinerator: comparison with other emission sources

The aim of this study was to calculate the incremental lifetime-risk to dioxins and furans (PCDD/Fs) for the population living in the surroundings of a municipal solid waste incinerator (MSWI), as well as to establish the potential reduction on human health risks as a consequence of the adaptation to the EU legislation on pollutant emissions from the MSWI stack. Analytical and modelled results were obtained. PCDD/F concentrations in environmental media were determined by means of a simple-compartment-multimedia model (air-soil-vegetation model). Predicted and measured PCDD/F concentrations in soils and vegetation were compared, and the effects of MSWI emissions in the environmental media were determined. Human health risks due to PCDD/F emissions from the MSWI were also estimated based on I-TEQ measured and modelled in various environmental media. Cancer risks due to PCDD/F emissions of the plant were 1.07E-07 and 3.08E-09, before and after installation of the clean air system, respectively. On the other hand, cancer risks due to other PCDD/F emission sources in the area were 5.54E-06 and 1.86E-06. Total PCDD/F cancer risks (including those from diet) for the population living in the vicinity of the MSWI were 1.3E-04 and 4.25E-05, respectively (67.6% of reduction). Hazard ratio for total PCDD/F exposure (including diet) decreased during the last 5 years from 1.16 to 0.38. The above data show that other emission sources of PCDD/Fs also have a notable environmental impact on the area under direct influence of the MSWI.     

Radiological risk assessment and biosphere modelling for radioactive waste disposal in Switzerland

Long-term safety assessments for geological disposal of radioactive waste in Switzerland involve the demonstration that the annual radiation dose to humans due to the potential release of radionuclides from the waste repository into the biosphere will not exceed the regulatory limit of 0.1 mSv. Here, we describe the simple but robust approach used by Nagra (Swiss National Cooperative for the Disposal of Radioactive Waste) to quantify the dose to humans as a result to time-dependent release of radionuclides from the geosphere into the biosphere. The model calculates the concentrations of radionuclides in different terrestrial and aquatic compartments of the surface environment. The fluxes of water and solids within the environment are the drivers for the exchange of radionuclides between these compartments. The calculated radionuclide concentrations in the biosphere are then used to estimate the radiation doses to humans due to various exposure paths (e.g. ingestion of radionuclides via drinking water and food, inhalation of radionuclides, external irradiation from radionuclides in soils). In this paper we also discuss recent new achievements and planned future work.     

Principles and issues in radiological ecological risk assessment

This paper provides a bridge between the fields of ecological risk assessment (ERA) and radioecology by presenting key biota dose assessment issues identified in the US Department of Energy's Graded Approach for Evaluating Radiation Doses to Aquatic and Terrestrial Biota in a manner consistent with the US Environmental Protection Agency's framework for ERA. Current radiological ERA methods and data are intended for use in protecting natural populations of biota, rather than individual members of a population. Potentially susceptible receptors include vertebrates and terrestrial plants. One must ensure that all media, radionuclides (including short-lived radioactive decay products), types of radiations (i.e., alpha particles, electrons, and photons), and pathways (i.e., internal and external contamination) are combined in each exposure scenario. The relative biological effectiveness of alpha particles with respect to deterministic effects must also be considered. Expected safe levels of exposure are available for the protection of natural populations of aquatic biota (10 mGy d(-1)) and terrestrial plants (10 mGy d(-1)) and animals (1 mGy d(-1)) and are appropriate for use in all radiological ERA tiers, provided that appropriate exposure assumptions are used. Caution must be exercised (and a thorough justification provided) if more restrictive limits are selected, to ensure that the supporting data are of high quality, reproducible, and clearly relevant to the protection of natural populations.     

An examination of ecological risk assessment and management practices

Ecological risk assessment has grown and evolved since the 1980s, as have new challenges (e.g. global climate change, loss of habitat and biodiversity and the effects of multiple anthropogenic chemicals on ecological systems) that need to be factored into the risk assessment processes. There is also an on-going shift from evaluating adverse health impacts on particular, often small scale, environments to undertaking more complex ecological assessments of whole populations and communities across ecologically meaningful landscapes. These trends are generating an increased demand for much more complex ecological assessments, making it increasingly clear that to achieve its potential as a management tool, methods must be developed to apply ecological risk assessment to larger and more complex scales. This paper reviews the development of the ecological risk assessment paradigm in the United States, identifies ways it is being applied and adapted in other countries, explores future research needs and practice improvements, and examines current issues that need to be considered in taking forward the scientific development of ecological risk assessment as a useful environmental management tool.     

Perfluoroalkyl and polyfluoroalkyl substances in cord blood of newborns in Shanghai,China: Implications for risk assessment

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are commonly used in industrial applications and consumer products, and their potential health impacts are of concern, especially for vulnerable population like fetuses. However, in utero exposure to PFASs and health implications are far from fully characterized in China. To fill in the gap, we analyzed 10 PFASs in cord plasma samples (N = 687) collected in Shanghai between 2011 and 2012, one of the regions widely polluted with PFASs in China. A questionnaire survey on maternal and diet-related factors was conducted. Except for perfluoroheptanoic acid (PFHpA) and perfluorooctane sulfonamide (PFOSA), all other PFASs were detected in ˃90% of the samples. Perfluorooctanoic acid (PFOA) was the most predominant PFAS (median value: 6.96 ng/mL), followed by perfluorooctane sulfonate (PFOS) (2.48 ng/mL). PFOA and PFOS combined contributed to 80% of the total PFASs. The final multiple regression models showed that maternal factors including maternal age, body mass index, gestational age, economic status and educational level as well as consumption of fish and wheat were significantly related with concentrations of PFASs in cord blood. The risk assessment using the hazard quotients (HQs) approach on the basis of plasma PFAS levels indicated no potential concern for developmental toxicity in the local newborns. The results demonstrate the unique profiles of local prenatal exposure to PFASs, suggesting that PFOA has been the primary human exposure due to its widespread use and pollution. Special attention to high PFOA exposure and confirmation of potential determinants should be taken as a priority in the future plan for risk management and actions in this area.