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41.
42.
Koji Yachiguchi Noriko Matsumoto Yuki Haga Motoharu Suzuki Chisato Matsumura Masahiro Tsurukawa Toshihiro Okuno Takeshi Nakano Kimi Kawabe Kei-ichiro Kitamura Akira Toriba Kazuichi Hayakawa Vishwajit S. Chowdhury Masato Endo Atsuhiko Chiba Toshio Sekiguchi Masaki Nakano Yoshiaki Tabuchi Takashi Kondo Shigehito Wada Hiroyuki Mishima Atsuhiko Hattori Nobuo Suzuki 《Environmental science and pollution research international》2014,21(10):6365-6372
To analyze the effect of polychlorinated biphenyl (PCB) 118 on fish bone metabolism, we examined osteoclastic and osteoblastic activities, as well as plasma calcium levels, in the scales of PCB (118)-injected goldfish. In addition, effect of PCB (118) on osteoclasts and osteoblasts was investigated in vitro. Immature goldfish, in which the endogenous effects of sex steroids are negligible, were used. PCB (118) was solubilized in dimethyl sulfoxide at a concentration of 10 ppm. At 1 and 2 days after PCB (118) injection (100 ng/g body weight), both osteoclastic and osteoblastic activities, and plasma calcium levels were measured. In an in vitro study, then, both osteoclastic and osteoblastic activities as well as each marker mRNA expression were examined. At 2 days, scale osteoclastic activity in PCB (118)-injected goldfish increased significantly, while osteoblastic activity did not change significantly. Corresponding to osteoclastic activity, plasma calcium levels increased significantly at 2 days after PCB (118) administration. Osteoclastic activation also occurred in the marker enzyme activities and mRNA expressions in vitro. Thus, we conclude that PCB (118) disrupts bone metabolism in goldfish both in vivo and in vitro experiments. 相似文献
43.
N-Nitrosodimethylamine (NDMA) is a potent carcinogen that yields a cancer risk of 10−6 at concentrations as low as 0.7 ng L−1. Tentative guideline values are set at 3 ng L−1 in California, USA; 9 ng L−1 in Ontario, Canada; 40 ng L−1 nationwide in Canada; and 100 ng L−1 by the World Health Organization. NDMA is a great concern in treating reclaimed water as well as drinking water. UV degradation can be considered effective degradation method. A 1-log reduction of NDMA is achieved by 1000 mJ cm−2 of a 254-nm low pressure (LP) mercury UV lamp. However, a higher degradation efficiency than that provided by LP lamps is desired in practical treatment. In this study, the effects of wavelength and water quality were investigated to achieve higher degradation efficiency. The effects of wavelength were examined by comparing three UV lamps: a 222-nm Kr Cl Excimer UV lamp, a 254-nm LP mercury UV lamp, and a 230- to 270-nm filtered medium pressure (FMP) mercury UV lamp. The 222-nm lamp and FMP lamp achieved 4 times and 2.8 times higher degradation efficiency, respectively, than the conventional 254-nm LP lamp. Effects on water quality were also simulated by using absorption spectrum data of nitrate solutions and process water from a drinking-water treatment plant. In the simulation, the 222-nm lamp was affected by UV-absorbing compounds in the water, whereas the FMP lamp showed more stable degradation efficiency. Appropriate use of these three types of lamps could enhance the efficiency of degradation of NDMA. 相似文献
44.
Nakayama SM Ikenaka Y Hamada K Muzandu K Choongo K Teraoka H Mizuno N Ishizuka M 《Environmental pollution (Barking, Essex : 1987)》2011,159(1):175-181
Metal (Cr, Co, Cu, Zn, Cd, Pb, Ni) and metalloid (As) accumulation was studied in roadside soil and wild rat (Rattus sp.) samples from near a Pb-Zn mine (Kabwe, Zambia) and the capital city of Zambia (Lusaka). The concentrations of the seven metals and As in the soil samples and Pb in the rat tissue samples were quantified using atomic absorption spectroscopy. The concentrations of Pb, Zn, Cu, Cd, and As in Kabwe soil were much higher than benchmark values. Geographic Information System analysis indicated the source of metal pollution was mining and smelting activity. Interestingly, the area south of the mine was more highly contaminated even though the prevailing wind flow was westward. Wild rats from Kabwe had much higher tissue concentrations of Pb than those from Lusaka. Their body weight and renal Pb levels were negatively correlated, which suggests that mining activity might affect terrestrial animals in Kabwe. 相似文献
45.
The thyroid hormone agonist/antagonist activities of halogenated derivatives of bisphenol A (BPA) were assessed using a yeast two-hybrid assay incorporating the human thyroid hormone α (TRα), both with and without possible metabolic activation by rat liver S9 preparation. In the absence of the rat liver S9 preparation, 3,3′,5,5′-tetrabromobisphenol A (TBBPA), 3,3′,5,5′-tetrachlorobisphenol A (TCBPA), and 3,3′,5-trichlorobisphenol A (3,3′,5-triClBPA) exhibited agonist activity, whereas 3-chlorobisphenol A (3-ClBPA), 3,5-dichlorobisphenol A (3,5-diClBPA), 3,3′-dichlorobisphenol A (3,3′-diClBPA), and BPA did not. The activities of TBBPA and TCBPA increased markedly (7.6-fold and 3.1-fold, respectively) after their metabolic activation with the rat liver S9 preparation. TBBPA, TCBPA, and 3,3′,5-triClBPA inhibited the binding of triiodothyronine (T3) to TRα at 2 × 10−5 M without rat liver S9 treatment and 4 × 10−6 M with rat liver S9 treatment, demonstrating their T3 antagonist activity. These results revealed that metabolic activation by rat liver S9 significantly increased the agonist/antagonist potential of some halogenated BPAs. 相似文献
46.
Jun Shishido Keiko Yoshii Yoshihiro Takubo Koji Yamamoto Takeshi Yamamoto Yoshiko Kato Tsutomu Nishihara Masaomi Kondo 《Chemosphere》1984,13(2):321-330
A retrieval system of mass spectra based upon the Probability Based Matching method was studied in order to apply it to survey the chemicals in environments by a gas chromatography-mass spectrometry-computer system. As retrieval indices, peak missing probability and relative confidence value were proposed. 相似文献
47.
Regional Environmental Change - Bangladesh is reported to suffer from climatic changes, and local people begin to wonder that six seasons in Bangladeshi annual calendar transition to four seasons.... 相似文献
48.
49.
Faruque Ahmed M. Hawa Bibi Takehiko Fukushima Koji Seto Hiroaki Ishiga 《Environmental monitoring and assessment》2011,173(1-4):167-180
A geochemical study of the bottom sediments of Lake Shinji and the River Ohashi in southwestern Japan was carried out to determine their elemental compositions and to evaluate the pollution status of lake sediments by employing enrichment factor (EF), pollution load index (PLI), and geoaccumulation index (I geo). Present-day water quality was also assessed. Results showed that the water quality of Lake Shinji contrasts slightly between the upper and lower parts. The chemical composition of the sediments, as measured by X-ray fluorescence, included major and trace elements and total sulfur (TS). Average abundances of As, Pb, Zn, Cu, Ni, and Cr in the Shinji sediments were 10, 29, 143, 27, 19, and 54 ppm, respectively, compared to 6, 18, 57, 16, 10, and 37 ppm in the river sediments. Based on the EF, PLI, and I geo, the lake sediments are moderately to strongly polluted with respect to As, moderately polluted with Pb, Zn, and Cr, and unpolluted with Cu and Ni. The high EF and I geo for As, Pb, and Zn in the lake sediments indicate that metal concentration has occurred in Shinji. Increases in the abundances of these metals are likely related to the fine-grained nature of the sediments, reducing conditions of the bottom sediments, enrichment in organic matter, and possibly a minor contribution from non-point anthropogenic sources. Trace metal contents are strongly correlated with Fe2O3 and TS, suggesting that Fe oxides and sulfides play a role in controlling abundances in the investigated areas. 相似文献
50.
Objective: This study aimed at investigating the effects of vehicle impact velocity, vehicle front-end shape, and pedestrian size on injury risk to pedestrians in collisions with passenger vehicles with various frontal shapes. Method: A series of parametric studies was carried out using 2 total human model for safety (THUMS) pedestrian models (177 and 165?cm) and 4 vehicle finite element (FE) models with different front-end shapes (medium-size sedan, minicar, one-box vehicle, and sport utility vehicle [SUV]). The effects of the impact velocity on pedestrian injury risk were analyzed at velocities of 20, 30, 40, and 50?km/h. The dynamic response of the pedestrian was investigated, and the injury risk to the head, chest, pelvis, and lower extremities was compared in terms of the injury parameters head injury criteria (HIC), chest deflection, and von Mises stress distribution of the rib cage, pelvis force, and bending moment diagram of the lower extremities. Result: Vehicle impact velocity has the most significant influence on injury severity for adult pedestrians. All injury parameters can be reduced in severity by decreasing vehicle impact velocities. The head and lower extremities are at greater risk of injury in medium-size sedan and SUV collisions. The chest injury risk was particularly high in one-box vehicle impacts. The fracture risk of the pelvis was also high in one-box vehicle and SUV collisions. In minicar collisions, the injury risk was the smallest if the head did not make contact with the A-pillar. Conclusion: The vehicle impact velocity and vehicle front-end shape are 2 dominant factors that influence the pedestrian kinematics and injury severity. A significant reduction of all injuries can be achieved for all vehicle types when the vehicle impact velocity is less than 30?km/h. Vehicle designs consisting of a short front-end and a wide windshield area can protect pedestrians from fatalities. The results also could be valuable in the design of a pedestrian-friendly vehicle front-end shape. [Supplementary materials are available for this article. Go to the publisher's online edition of Traffic Injury Prevention for the following free supplemental resource: Head impact conditions and injury parameters in four-type vehicle collisions and validation result of the finite element model of one-box vehicle and minicar. ]. 相似文献