Biochemical profiling of lead-intoxicated impaired lipid metabolism and its amelioration using plant-based bioactive compound

The aim of this study was to investigate the lead (Pb)-induced lipid metabolism impairment and its amelioration using plant-based therapeutic interventions. Pb-induced hepatotoxicity can disturb the normal levels of natural antioxidant enzymes including glutathione (GSH) and superoxide dismutase (SOD) exerting a crucial impact on membrane unsaturated fatty acids (FA), hence leading to lipid peroxidation. Furthermore, Pb toxicity can also alter the regulation of various hormones involved in the synthesis of 3-hydroxy-methyl glutaryl CoA (HMG-CoA reductase), leading to an impairment in normal levels of serum cholesterol and other associated conjugated lipid molecules such HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol. In this study, the lipoprotein fractions, cholesterol, triglyceride (TGs) and biomarkers of liver functions were estimated by employing respective assay kits. The levels of antioxidant enzymes, FFAs and HMG-CoA reductase were determined by employing sandwich ELISA method. The administration of PbAc in experimental rats induced a significant disturbance in lipid profile (P < 0.05) accompanying a significant reduction in natural antioxidant defence system (P < 0.05). The significant alteration in the levels of serum antioxidant enzymes can lead to membrane lipid peroxidation that is reflected by a significantly (P < 0.05) high level of serum MDA in PbAc-induced experimental rats. However, the administration of resveratrol proved therapeutically effective in the treatment of Pb toxicity. Overall, the results of this study accompanying histopathological examination had proved the ameliorating effect of resveratrol in Pb-induced lipid metabolism impairment by adopting vitamin C as a standard therapeutic intervention.

     

Sustainability and mechanical property assessment of concrete incorporating eggshell powder and silica fume as binary and ternary cementitious materials

Environmental Science and Pollution Research - Cement production emits a significant carbon dioxide (CO2) gas, dramatically influencing the environment. Furthermore, a large amount of energy is...     

Types,sources, socioeconomic impacts,and control strategies of environmental noise: a review

Noise exposure has reached an alarming degree over the years because of rapid growth in the industry, transportation, and urbanization. Therefore, it is a dire need to provide awareness of the sources and mitigation strategies of noise, and to highlight the health, and socio-economic impacts of noise. A few research studies have documented this emerging issue; however, there is no comprehensive document describing all types of noise, their impacts on living organisms, and control strategies. This review article summarizes the sources of noise; their effects on industrial workers, citizens, and animals; and the value of property in noisy areas. The plethora of literature is showing an increased level of noise in various cities of the world, which have various health consequences such as high blood pressure, insomnia, nausea, heart attack, exhaustion, dizziness, headache, and triggered hearing loss. Apart from humans, noise also affects animal habitat, preying, and reproduction ability; increases heart rate and hearing loss to even death and loss in property value; and impairs the hospital environment. Finally, we have discussed the possible strategies to mitigate the noise problem, policy statements, and regulations to be followed, with future research directions based on the identified research gaps.

     

Retesting the EKC hypothesis through transmission of the ARMEY curve model: an alternative composite model approach with theory and policy implications for NAFTA countries

Environmental Science and Pollution Research - We investigate the validity of the environmental Kuznets curve (EKC) hypothesis for the NAFTA countries. In this investigation, we approach this...     

A Stereoselective Route to R-(+)-Limonene-Based Non-isocyanate Poly(hydroxyurethanes)

Journal of Polymers and the Environment - Bio-based non-isocyanate poly(hydroxyurethanes) (NIPUs) have recently gained significant interest due to increasing awareness of the health and...     

Sustainable supply chain management and green technologies: a bibliometric review of literature

Environmental Science and Pollution Research - To attain ecological sustainability and transition to sustainable supply chain management (SSCM), effective technological innovation (TI) and solid...     

Does economic complexity matter for environmental sustainability? Using ecological footprint as an indicator

Environment, Development and Sustainability - The current decade has witnessed the rise of empirical research in the domain of ecological footprint which has become a major scholarly area among...     

A quantitative investigation of methane gas and solid waste management in mountainous Srinagar city-A case study

Journal of Material Cycles and Waste Management - Methane has tremendous potential for energy production, and enormous amounts of energy can be produced using suitable technology. To address this...     

Analytical solutions of contaminant transport in homogeneous and isotropic aquifer in three-dimensional groundwater flow

Environmental Science and Pollution Research - Modeling three-dimensional contaminant transport released from arbitrary shape source geometries is useful in hydrological and environmental sciences....     

How climate change is impacting the major yield crops of Pakistan? an exploration from long- and short-run estimation

Environmental Science and Pollution Research - This research attempts to evaluate the linkage among climatic change factors such as average temperature and rainfall patterns and non-climatic...