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941.
Approaches to assess the oral bioaccessibility of persistent organic pollutants: a critical review 总被引:3,自引:0,他引:3
Oral bioaccessibility, also known as in vitro gastrointestinal extraction or the physiologically based extraction test (PBET), is an important tool when assessing the risk to humans from persistent organic pollutants (POPs) (and metals). The approach seeks to mimic the processes of human food digestion and thereby assess the bioavailability of POPs (and metals) from materials consumed either accidentally or intentionally in the diet. In vitro conditions are created to simulate various actions in the stomach and intestines (although some methods also include the mouth compartment). This paper reviews the current status of oral bioaccessibility with respect to the release of POPs from soil and related samples of environmental importance. Particular emphasis is placed on the parameters that influence gastrointestinal extraction including gastric and intestinal pH, enzymes, bile salts, food constituents and residence time. In addition, important developments in the use of in vitro gastrointestinal extraction are highlighted. These developments include the use of epithelial Caco-2 cells to mimic the intestinal cell lining, the potential for biotransformation of POPs into estrogenic metabolites as a result of colon microbiota, and the use of in vivo studies to validate existing approaches. 相似文献
942.
943.
We used genotypic data from three highly polymorphic microsatellite loci (two autosomal and one sex-linked) to examine micro-spatial
and temporal arrangements of genetic paternity for more than 1,500 embryos housed along 12 egg-case strings of the knobbed
whelk, Busycon carica. Multiple paternity proved to be the norm in these single-dam families, with genetic contributions of several sires (at least
3.5 on average) being represented among embryos within individual egg capsules as well as along the string. Two strings were
studied in much greater detail; five and seven fathers were identified, none of which was among the several males found in
consort with the female at her time of egg-laying. Each deduced sire had fathered roughly constant proportions of embryos
along most of the string, but those proportions differed consistently among fathers. A few significant paternity shifts at
specifiable positions along an egg-case string were also observed. Although the precise physical mechanisms inside a female
whelk’s reproductive tract remain unknown, our genetic findings indicate that successive fertilization events (and/or depositions
of zygotes into egg capsules) normally occur as near-random draws from a well-but-not-perfectly blended pool of gametes (or
zygotes) stemming from stored ejaculates, perhaps in different titers, of a dam’s several mates. 相似文献
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947.
We determined the concentrations of organochlorine pesticides and total PCBs in plasma of nestling Wood Storks (Mycteria americana) from two colonies in Georgia in 2000. Of 20 compounds analyzed for, only p,p'-DDE was quantified in reportable concentrations, ranging from <2.0-174.0 ng/g wet weight (ww). Concentrations of p,p'-DDE were significantly greater (P<0.0001) in plasma of nestlings from an inland colony, Chew Mill (x 16.9 ng/g,ww) than a coastal colony, Harris Neck (x 1.2 ng/g,ww). Concentrations from nestlings from Chew Mill were significantly different among sampling weeks (P=0.01), with week 8 being significantly greater than weeks 1, 2, and 5. While the Chew Mill colony had much greater concentrations of p,p'-DDE in plasma of nestlings than the Harris Neck colony, reproduction was greater there (1.8+/-1.0 SD fledged young per nesting attempt) than Harris Neck (1.4+/-1.0 SD fledged young per nesting attempt). While concentrations of p,p'-DDE determined in plasma of nestling Wood Storks are an indirect measure of adult exposure to environmental toxicants, concentrations reported would not be considered detrimental to reproduction in these colonies. 相似文献
948.
949.
The present study attempted to assess the extent to which job incumbents engage in performance relevant self-regulatory activities. Specifically, the degrees to which 62 insurance salespersons; (1) set performance goals, (2) monitored performance levels, and (3) exercised contingent self-reward or punishment with respect to goal achievement or goal failure were measured; and, the consequences that such activities had on performance were examined. The results of this study indicate that, in general, subjects set goals, but typically of a distal/result-orientated, as opposed to a proximal/behaviourally orientated-nature. Goal setting per se had no effects on sales performance, although an objective measure of goal difficulty was related to this criterion. With respect to self-monitoring, it was discovered that the greatest amount of performance feedback came from oneself and one's supervisor, as opposed to one's co-workers. In terms of performance, there was an interaction of feedback source and feedback preference such that the ability to generate internal feedback was related to performance only for individuals who had a preference for such internal feedback. There appeared to be no substantial amount of contingent self-reward occurring within this organization, although contingent self-punishment (in the form of self-criticism) was in evidence; and, such self-admonishment seemed to have detrimental effects on performance. While the three classes of variables independently explained 26 per cent of the variance in performance, the interactive effects suggested by theories of self-regulation (Bandura, 1977; Kanfer, 1971) were not in evidence. 相似文献
950.
Experimental warming, not grazing, decreases rangeland quality on the Tibetan Plateau. 总被引:8,自引:0,他引:8
We investigated experimental warming and simulated grazing (clipping) effects on rangeland quality, as indicated by vegetation production and nutritive quality, in winter-grazed meadows and summer-grazed shrublands on the Tibetan Plateau, a rangeland system experiencing climatic and pastoral land use changes. Warming decreased total aboveground net primary productivity (ANPP) by 40 g x m(-2) x yr(-1) at the meadow habitats and decreased palatable ANPP (total ANPP minus non-palatable forb ANPP) by 10 g x m(-2) x yr(-1) at both habitats. The decreased production of the medicinal forb Gentiana straminea and the increased production of the non-palatable forb Stellera chamaejasme with warming also reduced rangeland quality. At the shrubland habitats, warming resulted in less digestible shrubs, whose foliage contains 25% digestible dry matter (DDM), replacing more digestible graminoids, whose foliage contains 60% DDM. This shift from graminoids to shrubs not only results in lower-quality forage, but could also have important consequences for future domestic herd composition. Although warming extended the growing season in non-clipped plots, the reduced rangeland quality due to decreased vegetative production and nutritive quality will likely overwhelm the improved rangeland quality associated with an extended growing season. Grazing maintained or improved rangeland quality by increasing total ANPP by 20-40 g x m(-2) x yr(-1) with no effect on palatable ANPP. Grazing effects on forage nutritive quality, as measured by foliar nitrogen and carbon content and by shifts in plant group ANPP, resulted in improved forage quality. Grazing extended the growing season at both habitats, and it advanced the growing season at the meadows. Synergistic interactions between warming and grazing were present, such that grazing mediated the warming-induced declines in vegetation production and nutritive quality. Moreover, combined treatment effects were nonadditive, suggesting that we cannot predict the combined effect of global changes and human activities from single-factor studies. Our findings suggest that the rangelands on the Tibetan Plateau, and the pastoralists who depend on them, may be vulnerable to future climate changes. Grazing can mitigate the negative warming effects on rangeland quality. For example, grazing management may be an important tool to keep warming-induced shrub expansion in check. Moreover, flexible and opportunistic grazing management will be required in a warmer future. 相似文献