The occurrence and fate of residues from the therapeutic use of the non-steroidal anti-inflammatory drug metamizole have been studied in investigations of sewage effluents from a military hospital, municipal sewers and a sewage treatment plant (STP) in Berlin, Germany. The loads of the metabolites aminoantipyrin (AA), 4-acetylaminoantipyrin (AAA) and 4-formyl-aminoantipyrin (FAA), rapidly formed after the application of metamizole, were predicted from pharmacokinetic data and based on the evaluation of extensive data sets of on the administration in hospitals and private households. In parallel, the actual concentrations were measured within three field trials. For the military hospital, the estimated average annual discharges of AA/AAA and FAA were 10.5 and 3.2 kg, respectively. For the STP, annual loads of 333 and 133 kg were determined for AA/AAA and FAA, respectively. During sewage treatment, an average decrease of 26% of the loads was measured for AA/AAA whereas no changes were observed for FAA. Generally, the prediction of the loads resulted in an overestimation of the residue levels compared to those measured in the respective sewers. Thus, modeling of predicted loads or concentrations alone will not be sufficient for a realistic assessment. Concerns for human or other mammals' health are not expected from the occurrence of metamizole residues in the aquatic system measured at concentrations up to 7 microg l(-1) in STP effluents. However, a rest of uncertainty remains as it was not possible to derive a no observed effect level for the induction of rare but potentially fatal toxicological side effects reported for metamizole. 相似文献
Emissions from open burning of military food waste and ration packaging compositions were characterized in response to health concerns from open burning disposal of waste, such as at military forward operating bases. Emissions from current and prototype Meals, Ready-to-Eat (MREs), and material options for their associated fiberboard packaging were quantified to assess contributions of the individual components. MREs account for 67–100% of the particulate matter (PM), volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs), and polychlorinated dibenzo-p-dioxins and -furans (PCDDs/PCDFs) emissions when burned in unison with the current fiberboard container and liner. The majority of the particles emitted from these burns are of median diameter 2.5 µm (PM2.5). Metal emission factors were similar regardless of waste composition. Measurements of VOCs and PAHs indicate that targeted replacement of MRE components may be more effective in reducing emissions than variation of fiberboard-packaging types. Despite MRE composition variation, equivalent emission factors for PM, PAH, VOC, and PCDD/PCDF were seen. Similarly, for fiberboard packaging, composition variations exhibited essentially equivalent PM, PAH, VOC, and PCDD/PCDF emission factors amongst themselves. This study demonstrated a composition-specific analysis of waste burn emissions, assessing the impact of waste component substitution using military rations. 相似文献
Waste of electrical and electronic equipment (WEEE) constitutes one of the most relevant waste streams because of the quantity and presence of valuable materials. However, there is limited knowledge on the resource potential of urban mining WEEE, as data on material composition, and the efficiency of current recycling treatments are still scarce. In this article, an evaluation of the recycling performance at a national level for one of the fastest growing e-waste streams: LCD TVs is carried out through the following four steps. Firstly, material characterisation is performed by means of sampling of the waste stream. Secondly, a material flow analysis is conducted by evaluating the separation performance of a recycling plant in Belgium. Thirdly, the recovered economic value and avoided environmental impact (EI) of the analysed recycling system is assessed. Finally, the potential of urban mining for Belgium is forecasted. The analysis shows that while recycling performance for ferrous metals and aluminium are relatively high; there is substantial room to better close the material loops for precious metals (PM) and plastics. PMs and plastics account for 66 % of the economic value in LCD TVs and 57%of the EI.With the current, commonly applied recycling technology only one-third of the PM and housing plastics are recycled; meaning that for these materials, at a national level for Belgium, there is a potential for improvement that represents 3.3 million euros in 2016 and 6.8 million euros in 2025.
This paper describes a conceptual framework for solutions-focused management of chemical contaminants built on novel and systematic approaches for identifying, quantifying and reducing risks of these substances.
Methods
The conceptual framework was developed in interaction with stakeholders representing relevant authorities and organisations responsible for managing environmental quality of water bodies. Stakeholder needs were compiled via a survey and dialogue. The content of the conceptual framework was thereafter developed with inputs from relevant scientific disciplines.
Results
The conceptual framework consists of four access points: Chemicals, Environment, Abatement and Society, representing different aspects and approaches to engaging in the issue of chemical contamination of surface waters. It widens the scope for assessment and management of chemicals in comparison to a traditional (mostly) perchemical risk assessment approaches by including abatement- and societal approaches as optional solutions. The solution-focused approach implies an identification of abatement- and policy options upfront in the risk assessment process. The conceptual framework was designed for use in current and future chemical pollution assessments for the aquatic environment, including the specific challenges encountered in prioritising individual chemicals and mixtures, and is applicable for the development of approaches for safe chemical management in a broader sense. The four access points of the conceptual framework are interlinked by four key topics representing the main scientific challenges that need to be addressed, i.e.: identifying and prioritising hazardous chemicals at different scales; selecting relevant and efficient abatement options; providing regulatory support for chemicals management; predicting and prioritising future chemical risks. The conceptual framework aligns current challenges in the safe production and use of chemicals. The current state of knowledge and implementation of these challenges is described.
Conclusions
The use of the conceptual framework, and addressing the challenges, is intended to support: (1) forwarding sustainable use of chemicals, (2) identification of pollutants of priority concern for cost-effective management, (3) the selection of optimal abatement options and (4) the development and use of optimised legal and policy instruments.
The genomes of complex organisms, including the human genome, are highly structured. This structure takes the form of segmental
patterns of variation in various properties and may be caused by the division of genomes into regions of distinct function,
by the contingent evolutionary processes that gave rise to genomes, or by a combination of both. Whatever the cause, identifying
the change-points between segments is potentially important, as a means of discovering the functional components of a genome,
understanding the evolutionary processes involved, and fully describing genomic architecture. One property of genomes that
is known to display a segmental pattern of variation is GC content. The GC content of a portion of DNA is the proportion of
GC pairs that it contains. Sharp changes in GC content can be observed in human and other genomes. Such change-points may
be the boundaries of functional elements or may play a structural role. We model genome sequences as a multiple change-point
process, that is, a process in which sequential data are separated into segments by an unknown number of change-points, with
each segment supposed to have been generated by a different process. We consider a Sequential Importance Sampling approach
to change-point modeling using Monte Carlo simulation to find estimates of change-points as well as parameters of the process
on each segment. Numerical experiments illustrate the effectiveness of the approach. We obtain estimates for the locations
of change-points in artificially generated sequences and compare the accuracy of these estimates to those obtained via Markov
chain Monte Carlo and a well-known method, IsoFinder. We also provide examples with real data sets to illustrate the usefulness
of this method. 相似文献
Diver-towed global positioning systems (GPS) handhelds have been used for a few years in underwater monitoring studies. We
modeled the accuracy of this method using the software KABKURR originally developed by the University of Rostock for fishing
and marine engineering. Additionally, three field experiments were conducted to estimate the precision of the method and apply
it in the field: (1) an experiment of underwater transects from 5 to 35 m in the Southern Chile fjord region, (2) a transect
from 5 to 30 m under extreme climatic conditions in the Antarctic, and (3) an underwater tracking experiment at Lake Ranco,
Southern Chile. The coiled cable length in relation to water depth is the main error source besides the signal quality of
the GPS under calm weather conditions. The forces used in the model resulted in a displacement of 2.3 m in a depth of 5 m,
3.2 m at a 10-m depth, 4.6 m in a 20-m depth, 5.5 m at a 30-m depth, and 6.8 m in a 40-m depth, when only an additional 0.5 m
cable extension was used compared to the water depth. The GPS buoy requires good buoyancy in order to keep its position at
the water surface when the diver is trying to minimize any additional cable extension error. The diver has to apply a tensile
force for shortening the cable length at the lower cable end. Repeated diving along transect lines from 5 to 35 m resulted
only in small deviations independent of water depth indicating the precision of the method for monitoring studies. Routing
of given reference points with a Garmin 76CSx handheld placed in an underwater housing resulted in mean deviances less than
6 m at a water depth of 10 m. Thus, we can confirm that diver-towed GPS handhelds give promising results when used for underwater
research in shallow water and open a wide field of applicability, but no submeter accuracy is possible due to the different
error sources. 相似文献
Journal of Material Cycles and Waste Management - India currently has the second largest urban population worldwide, while facing an increasing burden on its urban solid waste infrastructure. To... 相似文献
Although protected areas represent a pivotal response to escalating anthropogenic threats, they face many pressures, inside and outside their boundaries. Amid these challenges, effective conservation is guided by evidence-based decision making supported by dynamic processes of learning and knowledge exchange. Although different models promote knowledge exchange, embedding research scientists within conservation agencies is best suited to supporting evidence-based conservation. Based on available literature and our experiences on several continents, we considered the benefits, challenges, and opportunities associated with embedding research scientists within conservation agencies and the research required to better understand the effectiveness of the embedding model for evidence-based conservation. Embedded researchers provide long-term commitment to building social capital among academic and nonacademic stakeholders; act as skilled gatekeepers who increase 2-way flow of knowledge between scientists and managers; attract, coordinate, and support management-relevant external research projects; drive the design and maintenance of long-term monitoring; and align their research with information needs. Notwithstanding the many benefits, research capacity of conservation agencies is declining worldwide. A significant challenge is that the values, structures, functions, and effectiveness of the embedding model of knowledge exchange remain poorly evaluated and documented. Also, embedded researchers have to balance their desire for creativity and flexibility with the standardization and quality control required by their public sector agencies; may be perceived as not credible because they are not truly independent of their agency; and have to couple scientific productivity with skills for transdisciplinary research, social facilitation, and stakeholder engagement. Systematic research on embedding and other models of knowledge exchange, across different world contexts, is required to better understand the benefits, costs, and institutional arrangements associated with different models. 相似文献
Knowledge co‐production and boundary work offer planners a new frame for critically designing a social process that fosters collaborative implementation of resulting plans. Knowledge co‐production involves stakeholders from diverse knowledge systems working iteratively toward common vision and action. Boundary work is a means of creating permeable knowledge boundaries that satisfy the needs of multiple social groups while guarding the functional integrity of contributing knowledge systems. Resulting products are boundary objects of mutual interest that maintain coherence across all knowledge boundaries. We examined how knowledge co‐production and boundary work can bridge the gap between planning and implementation and promote cross‐sectoral cooperation. We applied these concepts to well‐established stages in regional conservation planning within a national scale conservation planning project aimed at identifying areas for conserving rivers and wetlands of South Africa and developing an institutional environment for promoting their conservation. Knowledge co‐production occurred iteratively over 4 years in interactive stake‐holder workshops that included co‐development of national freshwater conservation goals and spatial data on freshwater biodiversity and local conservation feasibility; translation of goals into quantitative inputs that were used in Marxan to select draft priority conservation areas; review of draft priority areas; and packaging of resulting map products into an atlas and implementation manual to promote application of the priority area maps in 37 different decision‐making contexts. Knowledge co‐production stimulated dialogue and negotiation and built capacity for multi‐scale implementation beyond the project. The resulting maps and information integrated diverse knowledge types of over 450 stakeholders and represented >1000 years of collective experience. The maps provided a consistent national source of information on priority conservation areas for rivers and wetlands and have been applied in 25 of the 37 use contexts since their launch just over 3 years ago. When framed as a knowledge co‐production process supported by boundary work, regional conservation plans can be developed into valuable boundary objects that offer a tangible tool for multi‐agency cooperation around conservation. Our work provides practical guidance for promoting uptake of conservation science and contributes to an evidence base on how conservation efforts can be improved. 相似文献