Sustainable roofing technology under multiple constraints: a decision-analytical approach

Recent efforts in the private and public sectors to move toward enhanced sustainability in the built environment have prompted the need to quantify and assess trade-offs among relevant sustainability metrics. Within the US military, for instance, many technological improvements are available to facilitate the achievement of net-zero goals for installations. These technologies must be assessed based on numerous performance criteria, and these technology selection decisions are difficult to make unaided. This paper seeks to demonstrate the use of decision-analytical techniques in which sustainable roofing technology alternatives (reflective, vegetated, or solar roofs) can be properly framed and assessed while evaluating the trade-offs between multiple performance criteria. Multi-criteria decision analysis methods are used to assess the impact of technology alternatives on sustainability framed within the popular concept of the triple bottom line (economic, societal, and environmental concerns). The framework developed in this paper can be applied to other sustainability technologies (energy, water, waste) or portfolios of numerous technologies.     

Noninvasive prenatal screening for cystic fibrosis using circulating trophoblasts: Detection of the 50 most common disease-causing variants

Objectives

Cystic fibrosis (CF) is one of the most common severe autosomal recessive disorders. Prenatal or preconception CF screening is offered in some countries. A maternal blood sample in early pregnancy can provide circulating trophoblasts and offers a DNA source for genetic analysis of both the mother and the fetus. This study aimed to develop a cell-based noninvasive prenatal test (NIPT) to screen for the 50 most common CF variants.

Methods

Blood samples were collected from 30 pregnancies undergoing invasive diagnostics and circulating trophoblasts were harvested in 27. Cystic fibrosis testing was conducted using two different methods: by fragment length analysis and by our newly developed NGS-based CF analysis.

Results

In all 27 cases, cell-based NIPT provided a result using both methods in agreement with the invasive test result.

Conclusion

This study shows that cell-based NIPT for CF screening provides a reliable result without the need for partner- and proband samples.