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101.
The discovery of cell-free DNA (cfDNA) in maternal plasma has opened up new promises for the development of non-invasive prenatal testing (NIPT). Application of cfDNA in NIPT of fetus diseases and abnormalities is restricted by the low amount of fetal DNA molecules in maternal plasma. Fetus-derived cfDNA in maternal plasma are shorter than maternal DNA, thus leveraging the maternal and fetus-derived cfDNA molecules size difference has become a novel and more accurate method for NIPT. However, multiple biological properties such as size distribution of plasma DNA, proportion of fetal-derived DNA and methylation levels in maternal plasma across different gestational ages still remain largely unknown. Further insights into the size distribution and fragmentation pattern of circulating plasma cfDNA will shed light on the origin and fragmentation mechanisms of cfDNA during physiological and pathological processes in prenatal diseases and enhance our ability to take the advantage of plasma cfDNA as a molecular diagnostic tool. In the review, we start by summarizing the research techniques for the determination of the fragmentation profiles of cfDNA in maternal plasma. We then summarize the main progress and findings in size profiles of maternal plasma cfDNA and cffDNA. Finally, we discuss the potential diagnostic applications of plasma cfDNA size profiling. 相似文献
102.
Yongliang SUN Xiaoyan LI Heye XU Zhipeng YANG Jia TANG Xiaoying ZHANG 《Frontiers of Environmental Science & Engineering in China》2008,2(4):480-486
The development of soil crust on sandy land may affect the surface hydrological process. This paper investigates the process
of evaporation and dew deposition influenced by different soil surface types which were dominated by sand, primitive biotic
crust, and advanced biotic crust, respectively, in the south fringe of Mu Us sandy land in Northwest China from July to September
of 2006. The experimental results indicate that the advanced biotic crust could increase evaporation and dew deposition compared
to the primitive biotic crust and bare sand although the differences between them were not significant. The average evaporation
from advanced biotic crust, primitive biotic crust and sand was 6.8, 6.6, and 6.5 mm/d, respectively, and water content is
around 16.2 % in the condition of initially identical soil. The average dew amount on advanced biotic crust was 0.116 mm/d
with extreme 0.05 and 0.24 mm/d. The average values on primitive biotic crust and sand were 0.105 and 0.101 mm/d, respectively,
with extreme 0.04 and 0.21 mm/d for both treatments. Also, the dew deposition on advanced biotic crust seemed stable and might
rest for a longer time than that on primitive biotic crust and sand. The results suggest that the advanced biotic crust possibly
facilitates evaporation and dew deposition. Therefore, the development of biotic crust may potentially enhance the hydrological
circulation in the upper sand layer in sandy land. 相似文献
103.
104.
ZHANG Jian-ying QIU Li-min HE Jia LIAO Yuan LUO Yong-ming College of Environmental Resource Sciences Zhejiang University Hangzhou China. Soil Environment Bioremediation Research Center Institute of Soil Science Chinese Academy of Sciences Nanjing China 《环境科学学报(英文版)》2007,(3)
A total of 198 agricultural soil samples were collected from Zhangjiagang and Changshu in Southern Jiangsu for analysis of 13 polychlorinated biphenyls (PCBs) in order to assess the levels of pollution, sources, area distribution, and potential risk for the environment. All methods were rigorously tested and an adequate quality control was ensured. Only one site had no PCBs residues, and the highest total PCBs concentration in the surface soils was 32.83 ng/g. The average concentration in all the soil samples was 4.13 ng/g, signaling low-level pollution. Tetra-, penta-, and hexa-chlorinated biphenyls were dominant species in soil samples, accounting for more than 75% ofΣPCBs in the soil samples. PCB118 was the most abundant congener in all the samples. The PCB118 was about 20% ofΣPCBs. The soil organic matter content showed only a weak correlation with the levels of all PCB congeners, in which a better correlation was noted for the more volatile lighter PCB congeners than for the heavier homologues. To a certain extent, the sources and land use seemed to influence the levels of PCBs. 相似文献
105.
Novel 3D biogenic C-doped Bi_2 MoO_6/In_2O_3-ZnO Z-scheme heterojunctions were synthesized for the first time, using cotton fiber as template. The as-prepared samples showed excellent adsorption and photodegradation performance toward the hazardous antibiotic doxycycline under simulated sunlight irradiation. The morphology, phase composition and in situ carbon doping could be precisely controlled by adjusting processing parameters. The carbon doping in Bi_2 MoO_6/In_2O_3-ZnO was derived from the cotton template, and the carbon content could be varied in the range 0.9–4.4 wt.% via controlling the heat treatment temperature. The sample with Bi_2 MoO_6/In_2O_3-ZnO molar ratio of 1:2 and carbon content of1.1 wt.% exhibited the highest photocatalytic activity toward doxycycline degradation,which was 3.6 and 4.3 times higher than those of pure Bi_2 MoO_6 and Zn In Al-CLDH(calcined layered double hydroxides), respectively. It is believed that the Z-scheme heterojunction with C-doping, the 3D hierarchically micro–meso–macro porous structure, as well as the high adsorption capacity, contributed significantly to the enhanced photocatalytic activity. 相似文献
106.
107.
随着中国大力推广排污许可证制度在全国范围内的实施,排污许可限值作为排污许可证中的关键点,其重要性日益凸显。论文重点从排污许可限值核定技术的法律规范基础、基于技术和基于水质的核定技术3个方面,对比研究中美两国排污许可限值核定实践与科研现状。通过对比美国排污许可限值核定技术的特点与经验,分析总结出我国排污许可限值核定技术存在的法律法规不完善、技术指导文件不详细、基于技术的限值核定技术精确度低和基于水质的限值核定技术缺乏等问题,最终为我国排污许可限值核定技术在上述几个方面的完善提供建议。 相似文献
108.
运用生态学原理探讨了郑州市区域生态经济系统。人口与环境、生态系统彼此适应性与制约性,能源利用与推行清洁生产,资源利用与防治生态破坏。进而,探讨了郑州市生态经济系统管理的宗旨;生态工业建设目标定位于系统整体的最优化,力争使物质在系统中多资循环利用和多功能系统的完全代谢及从能量平衡和转换规律视“三废”为放错位置的“原料”,以及开展和完善城乡复合生态系统。 相似文献
109.
结合胜利油田电力生产实际,提出了基于HSE作业指导卡的风险精细管控模式,介绍了HSE作业指导卡的格式内容、工作流程和实施效果。 相似文献
110.
一维纳米结构是最吸引人的功能材料而被广泛关注.一维形态可以很容易地提高纳米结构的独特性能,使它们适合各种各样的应用程序,包括气体传感器、电致变色的设备、发光二极管、场发射器、超级电容器和纳米发电机.因此,目前已合成多种一维纳米结构形式的纳米棒、纳米线、纳米管、纳米带等.本文主要介绍了一维碳纳米管与金属氧化物的性质与研究现状,探讨两种材料的优缺点以期进行互补修饰合成新型复合材料. 相似文献