Mixed-sex populations of young adult zebrafish (~2-month-old) were exposed to measured RDX concentrations of 0, 1 or 9.6 ppm for up to 12 weeks followed by a 15-day rearing period in untreated water. RDX caused high mortality at 9.6 ppm, with most deaths occurring within the first 8 weeks of exposure. RDX at 9.6 ppm caused lower body weights at 4 and 8 weeks of exposure; and at 1 ppm, lower body weight was observed only at 4 weeks. Fish length was not affected by treatment at any time during the exposure period. The bioconcentration factor for RDX seemed to be influenced by time of exposure but not by water RDX concentration; its overall values were 1.01+/-0.13, 0.91+/-0.06 and 2.23+/-0.04 at 4, 8 weeks and 12 weeks, respectively. RDX was not detected in fish collected after the 15-day recovery period. In a separate experiment, adult females and males were separately exposed to RDX at measured concentrations of 0, 0.5 and 3.2 ppm for a period of 6 weeks. Reproductive performance was evaluated by biweekly breeding of the fish and measuring packed-egg volume (PEV) as index of fecundity. At 0.5 ppm, RDX caused elevated PEV levels relative to the control value at 2 weeks but not at 4 or 6 weeks, whereas no significant effects were noted at 3.2 ppm. Egg fertilization and embryo hatching rates were not affected by RDX at any of the concentrations tested. In conclusion, RDX at sublethal concentrations causes short-term negative effects on growth and, at 0.5 ppm, positive effects on fecundity. 相似文献
This article describes the collaborative modeling process and the resulting water resources planning model developed to evaluate water management scenarios in the transboundary Rio Grande basin. The Rio Grande is a severely water stressed basin that faces numerous management challenges as it crosses numerous jurisdictional boundaries. A collaborative process was undertaken to identify and model water management scenarios to improve water supply for stakeholders, the environment, and international obligations of water delivery from Mexico to the United States. A transparent and open process of data collection, model building, and scenario development was completed by a project steering committee composed of university, nongovernmental, and governmental experts from both countries. The outcome of the process was a planning model described in this article, with data and operations that were agreed on by water planning officials in each country. Water management scenarios were created from stakeholder input and were modeled and evaluated for effectiveness with the planning model. 相似文献
The current loss of biodiversity has put 50,000 plant species at an elevated risk of extinction worldwide. Conserving at-risk species is often complicated by covariance or nonadditivity among threats, which makes it difficult to determine optimal management strategies. We sought to demographically quantify covariance and nonadditive effects of more threats on more rare plant species than ever attempted in a single analysis. We used 1082 population reports from 186 populations across 3 U.S. states of 27 rare, herbaceous plant species collected over 15 years by citizen scientists. We used a linear mixed-effects model with 4 threats and their interactions as fixed predictors, species as a random predictor, and annual growth rates as the response. We found a significant 3-way interaction on annual growth rates; rare plant population sizes were reduced by 46% during the time immediately after disturbance when populations were also browsed by deer (Odocoileus virginianus) and had high levels of encroachment by woody species. This nonadditive effect should be considered a major threat to the persistence of rare plant species. Our results highlight the need for comprehensive, multithreat assessments to determine optimal conservation actions. 相似文献
Journal of Material Cycles and Waste Management - With sky-rocketing demand and unrestricted global production, plastics have become an inseparable part of daily human life and the circular economy... 相似文献
Environmental Science and Pollution Research - The production and demand of nanoparticles in the manufacturing sector and personal care products, release a large number of engineered nanoparticles... 相似文献
The objective of this research is to discuss the relationship between the growth of livestock and the environmental impact it generates in Colombia. For this, data were extracted from the FAO STAT for the period of 1961 to 2017. The livestock inventory has had a significant growth during the last 50 years. This has generated environmental exposure and the release of carbon, sequestered by continuous deforestation performed in the practice of extensive livestock. Recurring to vector error correction models, we observed the existence of long-term relations between CO2 emissions from dairy cattle and emissions from slaughtered cattle, deforestation, pastures, and forest development. Changes in CO2 emissions from dairy cattle tend to be anticipated by changes in CO2 emissions from the other analyzed sources, which prove how the current investment in dairy cattle results from the accumulated debates in Colombia regarding the different sources of livestock emissions.
- DOI: http://dx.doi.org/10.1065/espr2006.01.014
Background, Aims and Scope Triazole-derivatives are potent antifungal agents used as systemic agricultural fungicides and against fungal diseases in
humans and domestic animals. They act by inhibiting the cytochrome P-450 conversion of lanosterol to ergosterol, thus resulting
in faulty fungal cell wall synthesis. Some data have been published about the teratogenic activity of triazoles on rodent
embryos: Hypoplasias, abnormal shape, agenesis of the branchial arches, for example, were reported as typical induced malformations.
Unfortunately, no data are available on the embryotoxicity of these compounds in amphibians, despite the increasing concern
among the scientific community about the phenomenon of global amphibian population declines. The aim of the present work is
to evaluate the embryo-lethal and teratogenic potentials of Triadimefon (FON), a triazolederivative widely used as an antimycotic
in agriculture, by the test FETAX (Frog Embryos Teratogenic Assay, Xenopus) with particular attention being paid to the analysis
of branchial arch malformations.
Methods Xenopus laevis embryos were exposed continuously from stage 9 to increasing concentrations of FON and analyzed at stage 47
for mortality and teratogenicity (group I) to determine the median lethal (LC50) and teratogenic (TC50) concentrations. Another
two pools of larvae were exposed to FON for a 2 hour period at early gastrula (Group II) or neurula (Group III) stages to
verify which period of development is the most sensitive to FON. The malformations observed were further investigated by histological
section and cartilage staining with Alcian blue.
Results and Discussion The assay has estimated LC50 and TC50 values of 63.8 μM and 2.73 μM, respectively; the resulting TI (Teratogenic Index =
LC50/TC50) value of 23.4 has underlined the very high teratogenic risk associated with this compound. Neurulation was more
sensitive to FON exposure than gastrulation, since the TC50 estimated values for group III (neurula exposed) specimens was
7.6 times lower than those of group II (gastrula exposed). Interestingly, for each group analyzed, 100% of malformed embryos
showed alterations at branchial arch derived cartilages: Anterior cartilages were reduced, missing, fused or incorrectly positioned
while gill cartilages were altered only in the most severely affected specimens. In some cases these malformations were associated
with hyperpigmentation. Our results support the hypothesis that FON can interfere with Neural Crest Cell (NCC) migration,
since craniofacial components and melanophores are derived from neural crest material.
Conclusion In conclusion, our data show Triadimefon to be a potent teratogen able to induce specific craniofacial malformation in Xenopus
laevis embryos, probably interfering with the NCC migration into the branchial mesenchyme. These results are also interesting
for ecotoxicological reasons as FON, as well as other pesticides, are likely to be present in water systems near agricultural
or urban areas which may serve as habitats for developing amphibians and fishes.
Recommendation and Outlook Our results are in agreement with the data obtained on in vitro cultured rat embryos suggesting that the FON mechanism of
action involves strongly conserved molecules. The choice of Xenopus laevis as the model organism allows us to extend the toxicological
and teratological observations to a molecular level, in order to search for novel genes regulated by FON exposure. 相似文献