Does a ‘notched’ nuchal translucency indicate Down syndrome fetuses or other adverse pregnancy outcome?

The aim of the present study was to assess the sonographic contour of the increased nuchal translucency (NT) and to correlate this with pregnancy outcome. Fifty sonographic images of fetuses with increased NT [>95th centile thickness of the normal range for crown–rump length (CRL) between 38 and 84 mm] were retrospectively assessed. In all the cases a complete pregnancy and even infancy follow-up (<36 months) was available. The NT appearances were subdivided into two forms: a ‘notched’ or ‘uniform’ appearance. The images were correlated with karyotype results [trisomy 21 (DS) vs euploid cases] and pregnancy outcome. Complicated outcomes were classified as being either DS fetuses, miscarriage or termination of pregnancy because of structural anomaly. Thus 30/35 (86%) of the euploid fetuses had a ‘uniformly’ increased NT, whereas 8/13 DS cases (62%) had a ‘notched’ appearance (Fisher's exact test, p=0.004). Additionally, 27/29 fetuses (93%) which had an uneventful pregnancy outcome had a ‘uniform’ increased NT, whereas 12/26 (57%) of the fetuses which had adverse pregnancy outcome had a ‘notched’ appearance of their NT (Fisher's exact test, p<0.001). Although it was not possible to correlate the sonographic data with post-evacuation microdissection findings, it is possible that a uniformly shaped, increased NT may be more representative of a developmental delay in a normal fetus. Conversely, a ‘notched’ nuchal surface may represent abnormal lymphatic or cardiovascular development more commonly seen in DS fetuses. Copyright © 2001 John Wiley & Sons, Ltd.     

Diesel particulate emissions and the implications for the soiling of buildings

Summary The sources of dark smoke and particulate elemental carbon (PEC) in the London and United Kingdom atmospheres have been estimated from emission inventories. Diesels are responsible for about 60 percent of the dark smoke and 95 percent of the PEC in London, and about 30 percent of the dark smoke and 90 percent of the PEC in the UK. The role of PEC in the soiling of materials is considered. An experimental programme in the Hatfield Tunnel revealed a soiling rate constant of 1.9 yr^–1. The socio-economic implications of building soiling are considered.Dr Trudie Mansfield completed her postgraduate training at Middlesex Polytechnic, where her research supervisor, Dr Ron Hamilton, and Bryan Ellis are members of staff in the Urban Pollution Research Centre (address, Bounds Green Road, London N11 2NQ) and Peter Newby is a staff member in the School of Geography (address, Queensway, Enfield EN3 4SF). Trudie Mansfield is a Senior Scientific Officer in the Air Quality Division of the Department of the Environment.     

Protective shade, tree diversity and soil properties in coffee agroforestry systems in the Atlantic Rainforest biome

Sustainable production and biodiversity conservation can be mutually supportive in providing multiple ecosystem services to farmers and society. This study aimed to determine the contribution of agroforestry systems, as tested by family farmers in the Brazilian Rainforest region since 1993, to tree biodiversity and evaluated farmers’ criteria for tree species selection. In addition, long-term effects on microclimatic temperature conditions for coffee production and chemical and biological soil characteristics at the field scale were compared to full-sun coffee systems. A floristic inventory of 8 agroforests and 4 reference forest sites identified 231 tree species in total. Seventy-eight percent of the tree species found in agroforests were native. The variation in species composition among agroforests contributed to a greater γ-diversity than α-diversity. Monthly average maximum temperatures were approximately 6 °C higher in full-sun coffee than in agroforests and forests. Total soil organic C, N mineralization and soil microbial activity were higher in forests than in coffee systems, whereas the chemical and biological soil quality in agroforests did not differ significantly from full-sun coffee after 13 years. Given its contribution to the conservation of biodiversity and its capacity to adapt coffee production to future climate change, coffee agroforestry offers a promising strategy for the area.     

Probabilistic risk assessment and risk mapping of metals in tropical estuarine sediments using the 1 quarisk model

Total sediment concentrations of Cd, Cu, Pb, Zn, As, and Hg obtained from the Ankobra, Sakumo II, and Volta estuaries in Ghana were used to generate contaminant probability density distributions and species sensitivity distributions in AQUARISK. Results of the tier 1 assessment showed Cu, Cd, Zn, and Pb were not of concern in the Ankobra as their measured values and the 99th percentile of the fitted distributions were lower than the SQG low-trigger values. Mercury (Hg) and As were however, identified to be of concern in this estuary. In the Sakumo II estuary, Cu, Cd, Pb, and Hg have been identified to be of concern because their concentrations are higher than the SQG low-trigger values. Hg has been identified as the only metal of concern in the Volta estuary. The total proportion of species likely to be affected by the combined concentration of Cd, Cu, and Zn measured from Ankobra, Sakumo II, and Volta were 14%, 16%, and 12%, respectively, according to the Bur III distributional analysis of the ecotoxicology data. The measured median sediment concentrations of As and Hg in the Ankobra estuary greatly exceeded the median sediment concentration targets to achieve a 5% or less exceedence of the SQG low value. Similarly, in the Sakumo II estuary, the measured median sediment concentrations of Cu, Pb, and Hg greatly exceeded the median sediment concentration targets to achieve a 5% or less exceedence of the SQG low. For the Volta estuary however, other metals except Hg fall below the target values.     

Aviation and global climate change in the 21st century

Aviation emissions contribute to the radiative forcing (RF) of climate. Of importance are emissions of carbon dioxide (CO₂), nitrogen oxides (NO_x), aerosols and their precursors (soot and sulphate), and increased cloudiness in the form of persistent linear contrails and induced-cirrus cloudiness. The recent Fourth Assessment Report (AR4) of the Intergovernmental Panel on Climate Change (IPCC) quantified aviation's RF contribution for 2005 based upon 2000 operations data. Aviation has grown strongly over the past years, despite world-changing events in the early 2000s; the average annual passenger traffic growth rate was 5.3% yr^?1 between 2000 and 2007, resulting in an increase of passenger traffic of 38%. Presented here are updated values of aviation RF for 2005 based upon new operations data that show an increase in traffic of 22.5%, fuel use of 8.4% and total aviation RF of 14% (excluding induced-cirrus enhancement) over the period 2000–2005. The lack of physical process models and adequate observational data for aviation-induced cirrus effects limit confidence in quantifying their RF contribution. Total aviation RF (excluding induced cirrus) in 2005 was ～55 mW m^?2 (23–87 mW m^?2, 90% likelihood range), which was 3.5% (range 1.3–10%, 90% likelihood range) of total anthropogenic forcing. Including estimates for aviation-induced cirrus RF increases the total aviation RF in 2005–78 mW m^?2 (38–139 mW m^?2, 90% likelihood range), which represents 4.9% of total anthropogenic forcing (2–14%, 90% likelihood range). Future scenarios of aviation emissions for 2050 that are consistent with IPCC SRES A1 and B2 scenario assumptions have been presented that show an increase of fuel usage by factors of 2.7–3.9 over 2000. Simplified calculations of total aviation RF in 2050 indicate increases by factors of 3.0–4.0 over the 2000 value, representing 4–4.7% of total RF (excluding induced cirrus). An examination of a range of future technological options shows that substantive reductions in aviation fuel usage are possible only with the introduction of radical technologies. Incorporation of aviation into an emissions trading system offers the potential for overall (i.e., beyond the aviation sector) CO₂ emissions reductions. Proposals exist for introduction of such a system at a European level, but no agreement has been reached at a global level.     

Non-destructive pollution exposure assessment by means of wood mice hair

Concentrations of cadmium, copper, lead and zinc were measured in hair, kidney, liver, lung and muscle tissue of wood mice captured along a pollution gradient. We found positive relationships between cadmium concentrations in hair and all internal tissues. Hair lead concentrations were positively correlated with lead contents in kidney and liver. Age had a significant effect on cadmium accumulation in all tissues and hair. Apart from a very weak relationship between zinc concentrations in hair and liver, no significant relation between copper or zinc content in hair and any of the internal organs was observed. In summary, our observations suggest that hair of wood mice can be used for monitoring exposure to non-essential metals like cadmium and lead, but not to homeostatically regulated metals such as copper or zinc.     

Use of a Continuous Nephelometer to Measure Personal Exposure to Particles During the U.S. Environmental Protection Agency Baltimore and Fresno Panel Studies

ABSTRACT

In population exposure studies, personal exposure to PM is typically measured as a 12- to 24-hr integrated mass concentration. To better understand short-term variation in personal PM exposure, continuous (1-min averaging time) nephelometers were worn by 15 participants as part of two U.S. Environmental Protection Agency (EPA) longitudinal PM exposure studies conducted in Baltimore County, MD, and Fresno, CA. Participants also wore iner-tial impactor samplers (24-hr integrated filter samples) and recorded their daily activities in 15-min intervals. In Baltimore, the nephelometers correlated well (R² = 0.66) with the PM₂₅ impactors. Time-series plots of personal nephelometer data showed each participant's PM exposure to consist of a series of peaks of relatively short duration. Activities corresponding to a significant instrument response included cooking, outdoor activities, transportation, laundry, cleaning, shopping, gardening, moving between microenvironments, and removing/putting on the instrument. On average, 63-66% of the daily PM exposure occurred indoors at home (about 2/3 of which occurred during waking hours), primarily due to the large amount of time spent in that location (an average of 7277%). Although not a reference method for measuring mass concentration, the nephelometer did help identify PM sources and the relative contribution of those sources to an individual's personal exposure.     

The Influence of Human Activity Patterns on Personal PM Exposure: A Comparative Analysis of Filter-Based and Continuous Particle Measurements

ABSTRACT

Particulate matter (PM) exposure data from the U.S. Environmental Protection Agency (EPA)-sponsored 1998 Baltimore and 1999 Fresno PM exposure studies were analyzed to identify important microenvironments and activities that may lead to increased particle exposure for select elderly (>65 years old) subjects. Integrated 24-hr filter-based PM_2.5 or PM₁₀ mass measurements [using Personal Environmental Monitors(PEMs)] included personal measurements, indoor and outdoor residential measurements, and measurements at a central indoor site and a community monitoring site. A subset of the participants in each study wore passive nephelometers that continuously measured (1-min averaging time) particles ranging in size from 0.1 to ~10 um. Significant activities and locations were identified by a statistical mixed model (p < 0.01) for each study population based on the measured PM_2.5 or PM₁₀ mass and time activity data. Elevated PM concentrations were associated with traveling (car or bus), commercial locations (store, office, mall, etc.), restaurants, and working.

The modeled results were compared to continuous PM concentrations determined by the nephelometers while participants were in these locations. Overall, the nephelometer data agreed within 6% of the modeled PM_2.5 results for the Baltimore participants and within ~20% for the Fresno participants (variability was due to zero drift associated with the nephelometer). The nephelom-eter did not agree as well with the PM₁₀ mass measurements, most likely because the nephelometer optimally responds to fine particles (0.3–2 um). Approximately one-half (54 ± 31%; mean ± standard deviation from both studies) of the average daily PM_2.5 exposure occurred inside residences, where the participants spent an average of 83 ± 10% of their time. These data also showed that a significant portion of PM_2.5 exposure occurred in locations where participants spent only 4–13% of their time.     

Influence of pH and ozone dose on the content and structure of haloacetic acid precursors in groundwater

This study investigated the effects of pH (6-10) and ozone dose [0.4-3.0?mg O(3)/mg dissolved organic carbon (DOC)] on the content and structure of haloacetic acid (HAA) precursors in groundwater rich in natural organic matter (NOM; DOC 9.85?±?0.18?mg/L) during drinking water treatment. The raw water was ozonated in a 2 L glass column. NOM fractionation was carried out using XAD resins. HAA formation potential (HAAFP) was determined according to standard EPA Method 552. NOM characterization revealed it is mostly hydrophobic (65?% fulvic and 14?% humic acids). Hydrophobic NOM significantly influences HAA formation, as confirmed by the high HAAFP (309?±?15?μg/L). Ozonation at pH?6-10 led to changes in NOM structure, i.e. complete humic acid oxidation, and increased the hydrophilic NOM fraction content (65-90?% achieved using 3.0?mg O(3)/mg DOC). The highest degree of NOM oxidation and HAA precursor removal was achieved at pH?10 (up to 68?% HAAFP). Ozonation pH influenced the distribution of HAA precursor content, as increasing the pH from 6 to 10 increased the reactivity of the hydrophilic fraction, with the HAAFP increasing from 19.1?±?6.0?μg/mg DOC in raw water to 152?±?8?μg/mg DOC in ozonated water. The degree of HAA precursor removal depends on the dominant oxidation mechanism, which is related to the applied ozone dose and the pH of the oxidation process. Ozonation at pH?10 favours the mechanism of radical NOM oxidation and was the most effective for HAAFP reduction, with the efficacy of the process improving with increasing ozone dose.