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The aims of this study were to determine whether assumptions used in prenatal screening for Down syndrome in twin pregnancies are valid and derive estimates of risk and screening performance in twin pregnancies using observed data. Data were collected on nuchal translucency, chorionicity, pregnancy associated plasma protein-A (PAPP-A), and free ß human chorionic gonadotrophin (free ß-hCG) from 61 twin pregnancies with Down syndrome and 7302 unaffected twin pregnancies. Distribution parameters were determined and used to estimate screening performance. The assumption that proportional differences in serum marker levels in affected and unaffected singleton pregnancies apply to twin pregnancies was not confirmed. Median free β-hCG value in monochorionic affected twin pregnancies (2.63 multiples of the median [MoM]; 95% CI, 1.79-3.22 MoM) was lower than that assuming proportionality (3.76 MoM), and the median PAPP-A value in dichorionic affected twin pregnancies (1.88 MoM; 95% CI, 1.60-2.17 MoM) was higher than that based on proportionality (1.33 MoM). The detection rate was 87% for a 3% false-positive rate in monochorionic twin pregnancies and 74% in dichorionic twin pregnancies compared with 86% in singleton pregnancies. Estimates of screening performance in Down syndrome twin pregnancies do not need to rely on assumptions and can take account of chorionicity and gestational age.  相似文献   
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In this study a combined anaerobic/aerobic full-scale treatment plant designed for the treatment of the source-separated organic fraction of municipal solid waste (OFMSW) was monitored over a period of one year. During this period, full information was collected about the waste input material, the biogas production, the main rejects and the compost characteristics. The plant includes mechanical pre-treatment, dry thermophilic anaerobic digestion, tunnel composting system and a curing phase to produce compost. To perform the monitoring of the entire plant and the individual steps, traditional chemical methods were used but they present important limitations in determining the critical points and the efficiency of the stabilization of the organic matter. Respiration indices (dynamic and cumulative) allowed for the quantitative calculation of the efficiency of each treatment unit. The mass balance was calculated and expressed in terms of Mgy(-1) of wet (total) matter, carbon, nitrogen and phosphorus. Results show that during the pre-treatment step about 32% of the initial wet matter is rejected without any treatment. This also reduces the biodegradability of the organic matter that continues to the treatment process. About 50% of the initial nitrogen and 86.4% of the initial phosphorus are found in the final compost. The final compost also achieves a high level of stabilization with a dynamic respiration index of 0.3±0.1g O(2) per kg of total solids per hour, which implies a reduction of 93% from that of the raw OFMSW, without considering the losses of biodegradable organic matter in the refuse (32% of the total input). The anaerobic digestion process is the main contributor to this stabilization.  相似文献   
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The use of respiration indices in the composting process: a review.   总被引:1,自引:0,他引:1  
Respiration is directly related to the metabolic activity of a microbial population. Micro-organisms respire at higher rates in the presence of large amounts of bioavailable organic matter while respiration rate is slower if this type of material is scarce. In the composting process respiration activity has become an important parameter for the determination of the stability of compost. It is also used for the monitoring of the composting process and it is considered an important factor for the estimation of the maturity of the material. A wide range of respirometric protocols has been reported based either on CO2 production, O2 uptake or release of heat. The most common methods are those based on O2 uptake. Respirometric assays are affected by a number of parameters including temperature, humidity, and both incubation and pre-incubation conditions. Results from respirometries are generally expressed as 'respiration indices', most of them with their own units and basis. In consequence, some confusion exists when referring and comparing respiration indices. This is particularly important because current and future legislations define and measure the biological stability of waste on the basis of respiration activity of the material. This paper discusses and compares most common respiration indices currently used.  相似文献   
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This paper assesses the Bluff oyster fishery in New Zealand as a case study in common pool resource management. It discusses ways in which modern information technology, augmented by low-tech data gathering strategies and community ethnography, can be used to produce an integrated scientific and local knowledge-inspired fishery database that lends itself to fostering collaboration in resource management and planning. The specific context and state of the oyster fishery in Bluff are described. Issues regarding undocumented and ephemeral intergenerational knowledge, much of which is geospatial in nature, on the fishery, the current crisis that many see in the future of the fishery, and a lack of cohesion or common sense of purpose between the stakeholder groups are discussed. It is argued that the digital resource that results from the integration of local and scientific knowledge and the potential community building processes that can ensue from collaboration and dialogue around this centrepiece are of central importance in developing an oyster fishery management plan that is holistic in concept and sustainable in purpose.  相似文献   
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Two cases of twin reversed arterial perfusion (TRAP) sequence with relevant ultrasound features that would help an accurate diagnosis are described. Available management options are proposed and discussed.  相似文献   
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