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排序方式: 共有255条查询结果,搜索用时 31 毫秒
61.
Development and verification of a toxicokinetic model of polychlorinated biphenyl elimination in persons working in a contaminated building 总被引:1,自引:0,他引:1
BACKGROUND: Polychlorinated biphenyls are toxic and slowly degrading substances that have been in widespread industrial use in the 1960s and 1970s. Despite a worldwide reduction, environmental exposure remains an issue; the assessment of an individual's level of exposure at a given time in retrospect requires valid toxicokinetic modeling of the different PCB congeners. OBJECTIVES: To develop and verify a toxicokinetic model of the in vivo-degradation of PCB 28 and 52 in adult humans. METHODS: The plasma concentrations of PCB congeners were measured in 583 persons working in a contaminated building for an average of 14.7+/-9.6 years. The values were adapted to a simple pharmacokinetic model (yt = y0 x (1 - e(-kt))); the steady state concentration y0 was estimated based on the median values of persons working exposed more than 10 years. RESULTS: The steady state concentration of PCB 28 was 0.10 microg/l, that of PCB 52 0.02 microg/l. The half-life of the congeners was estimated based on a logarithmic regression analysis according to the model mentioned above; it was 2.18 (95% CI: 1.91-2.54) years for PCB 28 and 3.95 (95% CI: 3.55-4.45) years for PCB 52, respectively. Stepwise elimination of persons with very long employment duration did not reduce the estimated half-life. CONCLUSIONS: The estimated half-life is higher than previously published data especially for PCB 52. Possible reasons and implications of this finding are discussed. 相似文献
62.
Simon Holden Sapna Ahuja Amanda Ogilvy-Stuart Helen V. Firth Christoph Lees 《黑龙江环境通报》2007,27(6):566-567
We describe a case of Harlequin Icthyosis where the main 2D and 3D ultrasound findings were digital contractures as opposed to the more commonly described severe facial dysmorphisms. A prenatal finding of distal arthrogryposis can therefore include harlequin icthyosis as a differential diagnosis, where 3D ultrasound may then disclose the facial features more commonly associated with the condition. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
63.
Terry V.Callaghan Lars Olof Bjrn Yuri Chernov Terry Chapin Torben R.Christensen Brian Huntley Rolf A.Ims Margareta Johansson Dyanna Jolly Sven Jonasson Nadya Matveyeva Nicolai Panikov Walter Oechel Gus Shaver Sibyll Schaphoff Stephen Sitch Christoph Zckler 《Ambio-人类环境杂志》2004,33(7):362-368
引言
北极已成为对当前气候波动和预计的全球变暖增强的影响进行评估的重要地区.原因有以下几个方面:①在过去几十年中北极经历了大幅度的变暖过程(温度平均升高3℃,而在许多地区温度升高了4~5℃);②气候预测表明气候呈现持续变暖趋势,在2080年之前年平均气温升高4~5℃;③近期的气候变暖正在影响北极的环境和经济,这些影响还会加大,并对生活方式、文化及生态系统造成影响;④北极的变化可能会影响到地球上的其它地区. 相似文献
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65.
Thomas Frank Patrik Kehrli Christoph Germann 《Agriculture, ecosystems & environment》2007,120(2-4):377-383
Density and nutritional condition of the five carabid beetle species Agonum mülleri, Anchomenus dorsalis, Anisodactylus binotatus, Pterostichus vernalis and Poecilus cupreus was studied. Carabids were caught in sixteen 1–4-year-old wildflower areas, identified and counted, their nutritional condition was calculated and calculations were related to habitat parameters (i.e. wildflower area age, vegetation cover, soil water content, habitat size, surrounding landscape composition) and sex.Whereas the number of Anisodactylus binotatus caught responded positively to succession in wildflower areas, A. mülleri numbers tended to decrease and the other three species were unaffected. In a stepwise multiple regression species affiliation, sex and age of wildflower area explained together 98.5% of the variance in the pooled nutritional condition of Anchomenus dorsalis, Anisodactylus binotatus, A. mülleri and P. vernalis. Age of wildflower area alone explained 61.7% of the variance and age increased the nutritional condition of carabids. Correspondingly, nutritional condition of Poecilus cupreus was positively correlated with the age of wildflower area. Overall, the nutritional condition of the carabid assemblage studied increased from the first to the second year and then remained stable. To keep the proportion of 1-year-old wildflower areas low, wildflower areas should therefore be maintained for several years to improve the life conditions of carabid beetles and to enhance their beneficial effects in agroecosystems. 相似文献
66.
67.
Karl-Heinz Schwind Jamshid Hosseinpour Heidelore Fiedler Christoph Lau Otto Hutzinger 《Umweltwissenschaften und Schadstoff-Forschung》1994,6(5):243-246
Im Rahmen eines Untersuchungsprogrammes zur Schadstoffemission von Paraffin-, Stearin- und Bienenwachskerzen ohne Farb- und
Lackbeimischungen wurden sowohl die Wachse und Dochte als auch die Brandgase dieser Kerzen auf die toxikologisch besonders
relevanten Schadstoffklassen der PCDD/PCDF, PAK und kurzkettigen Aldehyde untersucht. Die toxikologische Bewertung kommt selbst
bei einem angenommenen „worst case“-Szenario und unter Berücksichtigung von geltenden Grenz- und Richtwerten zu dem Ergebnis,
da? von den untersuchten Kerzen kein zus?tzliches Gesundheitsrisiko ausgeht.
Exhaust fumes of paraffin, beeswax and stearin candles without any further paint or decorative element were analysed for the
toxicological important substance classes of PCDD/PCDF, PAH and short chain aldehydes. The candle waxes and wicks were investigated
for chlorinated dioxins, furans and some known precursors. Toxicological risk assessment shows that emissions of the investigated
candles are much lower than all administrative limitation values — even under “worst case conditions”. Thus, they do not produce
a toxicological risk for human health. 相似文献
68.
69.
70.
Stefan Gartiser Christoph Hafner Christoph Hercher Kerstin Kronenberger-Schäfer Albrecht Paschke 《Environmental science and pollution research international》2010,17(4):856-865