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Robert G. Hinners Joseph K. Burkart Myron Malanchuk William D. Wagner 《Environment international》1981,5(4-6)
It is the major intent of this report to examine the animal inhalation facilities at the EPA Health Effects Research Laboratory in Cincinnati, Ohio, associated with the exposure to the exhaust of diesel-powered equipment. The facility serves as a center for toxicologic evaluation, in relevant animal models, of potentially hazardous environmental pollutants from diesel engine exhaust. Briefly, the entire engine exhaust is mixed with filtered and conditioned air in a dilution tube. That diluted exhaust enters a large volume mixing chamber and a portion passes through dynamic flow irradiation chambers (to simulate sunlight) and is then conducted to animal exposure chambers. The system provides nonirradiated exhaust in the same concentration (directly from the mixing chamber) and also filtered, conditioned ambient air for control animal exposure. The major physical components of the diesel emission system include: air purifiers, animal exposure chambers, engine-dynamometers, irradiation chambers, monitoring instrumentation and data acquisition systems. 相似文献
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Amaral Rdos S de Vasconcelos WE Borges E Silveira SV Mazzilli BP 《Journal of environmental radioactivity》2005,82(3):383-393
The phosphate region located in the Northeast of Brazil covers an area of approximately 150 km long with an average width of 4 km, along the coast of the states of Pernambuco and Paraíba. The inhabitants of this area are exposed to natural radioactivity levels higher than the background values recorded in the literature, mainly due to the presence of uranium and its decay products in the phosphatic sediments. The main aim of this study was to determine the activity concentration of uranium and (226)Ra in foodstuffs cultivated in this area, where the phosphate mineral has been extracted. The activity concentrations found for uranium and (226)Ra in the foodstuffs analyzed varied from 13 to 186 mBq kg(-1) (wet weight), with a mean value of 46 mBq kg(-1) and from 43 to 2209 mBq kg(-1) (wet weight), with a mean value of 358 mBq kg(-1), respectively. The annual intake of these radionuclides, for rural residents, was 7.45 Bq for uranium and 69.3 Bq for (226)Ra. 相似文献
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Matocha CJ Karathanasis AD Rakshit S Wagner KM 《Journal of environmental quality》2005,34(5):1539-1546
Laboratory and field investigations have clearly demonstrated the important role of reduced iron (Fe(II)) in reductive transformations of first-row transition metal species. However, interactions of Fe(II) and copper (Cu) are not clearly understood. This study examined the reduction of Cu(II) by Fe(II) in stirred-batch experiments at pH 5.2 and 5.5 as influenced by chloride (Cl-) concentration (0.002-0.1 M), initial metal concentration (0.1-9.1 mM), and reaction time (1-60 min) under anoxic conditions. Reduction of Cu(II) to Cu(I) by dissolved Fe(II) was rapid under all experimental conditions and the stability of the products explains the driving force for the redox reaction. Under conditions of low [Cl-] and high initial metal concentration, >40% of total Cu and Fe were removed from solution after 1 min, which accompanied formation of a brownish-red precipitate. X-ray diffraction (XRD) patterns of the precipitates revealed the presence of cuprite (Cu2O), a Cu(I) mineral, based on d-spacings located at 0.248, 0.215, 0.151, and 0.129 nm. Fourier transform infrared (FTIR) spectroscopy corroborated XRD data for the presence of Cu2O, with features located at 518, 625, and 698 cm(-1). Increasing [Cl-] stabilized the dissolved Cu(I) product against Cu2O precipitation and resulted in more Fe precipitated from solution (relative to Cu) that appears to be present as poorly crystalline lepidocrocite (gamma-FeOOH). This process may be important in anoxic soil environments, where dissolved Fe(II) levels can accumulate. 相似文献
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The focus of this paper is cognitive convergence in a globally distributed team (GDT), defined as the process by which cognitive structures of distributed team members gradually become more similar over time. To explore the convergence process, we employed a longitudinal, ethnographic research strategy that allowed us to follow a naturally occurring GDT over a 14‐month period, producing a rich case study portraying factors and processes that influence convergence. Confirming previous studies, we find that increases in shared cognition alone are not sufficient to account for performance gains on a GDT. Rather, it may be necessary not only to increase the sharing of cognition, but also to reverse a pattern of increasing divergence that can result from rejection of key knowledge domains. We also found that several factors influence the process of cognitive convergence beyond direct knowledge sharing. These include: separate but parallel or similar learning experiences in a common context; the surfacing of hidden knowledge at remote sites by third‐party mediators or knowledge brokers; and shifts in agent self‐interest that motivate collaboration and trigger the negotiation of task interdependence. Also relevant to cognitive convergence on a GDT is the geographical distribution pattern of people and resources on the ground, and the different ways in which leaders exploit the historical, cultural and linguistic dimensions of such distribution to further their own political agendas. Several propositions related to these observations are suggested. We conclude that GDTs can be effective in bringing together divergent points of view to yield new organizational capabilities, but such benefits require that leaders and members recognize early and explicitly the existence and validity of their differences. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
246.
We have developed a basic concept for studying cell biological phenomena using an interdisciplinary approach starting from organic chemistry. Based on structural information available for a given biological phenomenon, unsolved chemical problems are identified. For their solution, new synthetic pathways and methods are developed, which reflect the state of the art in synthesising lipidated peptide conjugates. These compounds are used as molecular probes for the investigation of biological phenomena that involve both the determination of biophysical properties and cell biological studies. The interplay between organic synthesis, biophysics and cell biology in the study of protein lipidation may open up new and alternative opportunities to gain knowledge about the biological phenomenon that could not be obtained by employing biological techniques alone. This fruitful combination is highlighted using the Ras protein as an outstanding example. Included herein is: the development of methods for the synthesis of Ras-derived peptides and fully functional Ras proteins, the determination of the biophysical properties, in particular the ability to bind to model membranes, and finally the use of synthetic Ras peptides and proteins in cell biological experiments. 相似文献
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