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Fetal cardiac intervention was first proposed in the early 1990s to impact cardiac development and survival of fetuses with fetal aortic stenosis and evolving hypoplastic left heart syndrome (HLHS). Although initial attempts of fetal aortic valvuloplasty were unsuccessful and carried a high rate of morbidity and mortality, our collaborative group at the Brigham and Women's Hospital and Boston Children's Hospital have reinvigorated the procedure using improvements in imaging, anesthesia, balloon catheters, and surgical techniques. Two decades of experience have now allowed us to document the safety of in utero intervention and to achieve a better understanding of the impact of midgestation intervention on developing HLHS. Research into underlying genetics, predictive biomarkers, and ways to incorporate stem cell technology will hopefully allow us to further refine the procedure to most benefit children with this historically lethal disease. 相似文献
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Teh Louise S. L. Cheung William W. L. Sumaila U. Rashid 《Regional Environmental Change》2017,17(3):619-633
Regional Environmental Change - There is a critical need to develop effective strategies for the long-term sustainability of Canada’s oceans. However, this is challenged by uncertainty over... 相似文献
157.
David C Wilson Nadine A Smith Nick C Blakey Louise Shaxson 《Waste management & research》2007,25(3):247-256
The concept of a knowledge-based approach to policy making (also referred to as 'evidence-based policy making' or 'science meets policy') has been around for 10 years, and is widely 'signed up to' by Governments. This paper examines the theory and the practice at national government (using the UK as a case study) and European levels, looking at how the knowledge-based approach has been applied in waste and resources management. There is general agreement that a knowledge-(or evidence-) based approach to policy making is a 'good thing'; however putting the concept into practice has proven challenging and is still evolving. The linkages between researchers and policy makers need to be further strengthened, as does the 'demand' for evidence from policy; requiring policy specialists to articulate their requirements for evidence sufficiently well in advance, and to do so routinely, is still an area of weakness. Using a model developed by the UK's Department for Environment, Food and Rural Affairs (Defra), we examine in detail some of the implications of changing the question from 'is this good research on waste and resources issues?' to 'is this good evidence for waste and resources policy?'. The paper also provides recommendations for further work required to achieve this at a European level, and for priority areas where international co-ordination of waste and resources research could add most value to policy. 相似文献
158.
Humanity has entered a new phase of sustainability challenges, the Anthropocene, in which human development has reached a
scale where it affects vital planetary processes. Under the pressure from a quadruple squeeze—from population and development
pressures, the anthropogenic climate crisis, the anthropogenic ecosystem crisis, and the risk of deleterious tipping points
in the Earth system—the degrees of freedom for sustainable human exploitation of planet Earth are severely restrained. It
is in this reality that a new green revolution in world food production needs to occur, to attain food security and human
development over the coming decades. Global freshwater resources are, and will increasingly be, a fundamental limiting factor
in feeding the world. Current water vulnerabilities in the regions in most need of large agricultural productivity improvements
are projected to increase under the pressure from global environmental change. The sustainability challenge for world agriculture
has to be set within the new global sustainability context. We present new proposed sustainability criteria for world agriculture,
where world food production systems are transformed in order to allow humanity to stay within the safe operating space of
planetary boundaries. In order to secure global resilience and thereby raise the chances of planet Earth to remain in the
current desired state, conducive for human development on the long-term, these planetary boundaries need to be respected.
This calls for a triply green revolution, which not only more than doubles food production in many regions of the world, but
which also is environmentally sustainable, and invests in the untapped opportunities to use green water in rainfed agriculture
as a key source of future productivity enhancement. To achieve such a global transformation of agriculture, there is a need
for more innovative options for water interventions at the landscape scale, accounting for both green and blue water, as well
as a new focus on cross-scale interactions, feed-backs and risks for unwanted regime shifts in the agro-ecological landscape. 相似文献
159.
Vartika Mathur Tom O. G. Tytgat Rob M. de Graaf Vinay Kalia A. Sankara Reddy Louise E. M. Vet Nicole M. van Dam 《Chemoecology》2013,23(2):71-82
In their natural environment, plants are often attacked simultaneously by many insect species. The specificity of induced plant responses that is reported after single herbivore attacks may be compromised under double herbivory and this may influence later arriving herbivores. The present study focuses on the dynamics of induced plant responses induced by single and double herbivory, and their effects on successive herbivores. Morphological (leaf length, area and trichome density) and chemical changes (leaf alkenyl and indole glucosinolates) in Brassica juncea were evaluated 4, 10, 14 and 20 days after damage by the specialist Plutella xylostella alone, or together with the generalist Spodoptera litura. To assess the biological effect of the plant’s responses, the preference and performance of both herbivores on previously induced plants were measured. We found that alkenyl glucosinolates were induced 20 days after damage by P. xylostella alone, whereas their levels were elevated as early as 4 days after double herbivory. Trichome density was increased in both treatments, but was higher after double herbivory. Interestingly, there was an overall decrease in indole glucosinolates and an increase in leaf size due to damage by P. xylostella, which was not observed during double damage. S. litura preferred and performed better on undamaged plants, whereas P. xylostella preferred damaged plants and performed better on plants damaged 14 and 10 days after single and double herbivory, respectively. Our results suggest that temporal studies involving single versus multiple attacker situations are necessary to comprehend the role of induced plant responses in plant–herbivore interactions. 相似文献
160.
Extent of larval growth among marine invertebrates has potentially profound implications for performance by benthic recruits
because body size influences many biological processes. Among gastropods, feeding larvae often attain larger size at metamorphic
competence than non-feeding larvae of basal gastropod clades. Delay of metamorphosis can further influence size at recruitment
if larvae continue to grow during the delay. Some caenogastopod larvae grow during delayed metamorphosis, but opisthobranch
larvae do not. Data on larval growth of neritimorph gastropods are needed to help determine which of these growth patterns
for planktotrophic gastropod larvae is more derived. We cultured planktotrophic larvae from all three major gastropod clades
with feeding larvae through delays of metamorphosis of 3–10 weeks. Larvae of the caenogastropod Euspira lewisii and the euthyneurans Haminoea vesicula (Opisthobranchia) and Siphonaria denticulata (Pulmonata) conformed to previously described growth patterns for their respective major clades. Furthermore, the caenogastropod
continued to lengthen the prototroch (ciliary band for swimming and feeding) and to differentiate prospective post-metamorphic
structures (gill filaments and radular teeth) during delayed metamorphosis. Larvae of the neritimorph Nerita atramentosa arrested shell growth during delayed metamorphosis but the radula continued to elongate, a pattern most similar to that of
non-feeding larvae of Haliotis, a vetigastropod genus. Character mapping on a phylogenetic hypothesis suggests that large larval size and capacity for continued
growth during delayed metamorphosis, as exhibited by some caenogastropods, is a derived innovation among feeding gastropod
larvae. This novelty may have facilitated post-metamorphic evolution of predatory feeding using a long proboscis. 相似文献