内分泌干扰物对核受体二聚化影响的研究进展

环境内分泌干扰物(endocrine disrupting chemicals,EDCs)可模仿或拮抗天然激素与核受体结合,干扰核受体的同源或异源二聚,进而通过共调节因子的招募调控转录活性,最终引起内分泌干扰效应.目前研究主要针对EDCs与核受体的结合过程,忽视了其对核受体二聚化过程的影响,而该过程的阻断可直接导致转录失活.EDCs对于不同核受体二聚化的影响不同,只有激动剂EDCs能够促进雄激素受体(androgen receptor,AR)的同源二聚化,而雌激素受体(estrogen receptor,ER)在与具有激动或拮抗活性的EDCs结合后都可诱导ER二聚体的形成,但二聚化类型不同.通过检索ToxCast和Tox21数据库发现多达227种EDCs可以诱导ER二聚化,相比于ERα-ERα同源二聚体(6.09％ ～7.38％的活性率),EDCs更易诱导ERα-ERβ异源二聚体(11.25％ ～12.22％的活性率)和ERβ-ERβ同源二聚体(10.02％ ～11.69％的活性率).EDCs也能够差异性诱导其他核受体如维生素D受体(vitamin D receptor,VDR)与维甲酸X受体(retinoid X receptor,RXR)形成的异源二聚体,不同类型的二聚体对于研究EDCs转录活性的生理学相关性具有重要意义.基于经济合作与发展组织(Organization for Economic Co-operation and Development,OECD)报告的参考化学品研究发现,相比于配受体结合活性,二聚活性与转录活性之间有着更好的相关关系.本文从EDCs介导的核受体二聚化转录机制、二聚化与转录活性间的关系以及二聚化研究方法三方面,总结EDCs对核受体二聚化的影响,以期为深入理解EDCs的分子作用机制,推进化合物的内分泌干扰风险评估提供参考.     

Laboratory investigation on high- and low-temperature performances of asphalt mastics modified by waste oil shale ash

Journal of Material Cycles and Waste Management - The objective of this study was to use two kinds of waste oil shale ash (OSA) as partial replacements of conventional mineral filler for evaluating...     

Preparation and uranium (VI) biosorption for tri-amidoxime modified marine fungus material

Environmental Science and Pollution Research - The preparation, characterization, and uranium (VI) adsorption properties of tri-amidoxime modified marine fungus material (ZZF51-GPTS-EDA-AM/ZGEA)...     

Composting industry under the Chinese municipal solid waste sorting policy: challenges,opportunities, and directions

Environmental Science and Pollution Research -     

放空尾气回收技术在塔中油田的应用

塔中油田为解决油气生产过程中排放的放空尾气给油田节能环保工作带来的压力,采用移动撬装天然气处理装置回收放空尾气技术。大量放空尾气经脱硫、脱水、脱烃、增压后,再利用CNG罐车拉运至尾气回收站回收利用。尾气回收利用技术的实施节约了大量天然气,降低了油气田开发对环境的影响。     

灾害教育理论研究与实践的初步思考

防灾减灾是可持续发展战略的重大课题,防灾减灾目标的实现在很大程度上依靠灾害教育。在国际灾害教育图景下,结合我国自然灾害多发的地理国情与公民防灾素养不高的实际情况,思考如何进行灾害教育研究与实践,从基本概念入手,提出研究思路,进行国际比较梳理其发展历程,分析灾害教育研究现状与存在问题,提出构建我国灾害教育体系的策略与设想,以促进其发展,确保人民群众生命财产安全。     

An evaluation of maintenance strategy using risk based inspection

Risk based inspection (RBI) methodology was proposed to evaluate the maintenance strategy in industrial process which was constructed in one of the units of Fujian Oil Refinery ISOMAX unit. Using classic definition of risk, both the probability and consequence of accident or failure were investigated respectively under the support of risk-specific code. All equipment in this unit were evaluated and categorized into five risk zone based on the RBI result which covered five levels. In addition, an application of the analytical hierarchy process (AHP) to select the most practicable maintenance strategy for equipment which was located in each risk rating scale was described. To arrange the hierarchic structure and evaluation, four main criteria were defined for pairwise judgments. Finally, four possible alternative strategies were proposed for administrators on the site.     

截污调水后滇池表层沉积物中16种PAHs的分布特征

截污调水等工程实施后,滇池的外源污染已得到有效控制,表层沉积物等内源污染物应加以重视.为研究滇池表层沉积物中16种多环芳烃(PAHs)的分布特征,采用气相色谱-质谱联用法(GC-MS)分析了2016年12月采集的19个滇池表层沉积物样品的PAHs含量,解析其时空分布规律、来源及生态风险.滇池表层沉积物中总多环芳烃(TPAHs)的含量范围为92. 31～1 546. 78 ng·g~(-1),平均值为496. 30 ng·g~(-1),草海TPAHs含量(平均932. 37 ng·g~(-1))远高于外海(平均380. 02ng·g~(-1)),随着截污调水工程的开展,TPAHs含量较2012年大幅下降,已处于我国重点水域中较低水平.滇池表层沉积物中含量最高的物质为荧蒽(80. 65 ng·g~(-1)),毒性当量(TEQ)含量最高的物质为二苯并[a,h]蒽(42. 97 ng·g~(-1)). PAHs组成以4环及5～6环为主(分别占总含量的40. 38%和40. 22%),PAHs构成较以往大体一致.分子比值法分析结果表明,滇池表层沉积物中PAHs主要由生物质或煤的燃烧贡献.基于潜在生态风险标志对比法评估,全湖总体处于低风险水平,但草海的生态风险相对较高,值得进一步关注.本研究结果可为滇池水质的保持与提升提供基础数据和重要参考.