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31.
80·2 Per cent of 111 Down syndrome pregnancies had amniotic fluid (AF) alpha fetoprotein (AFP) levels on or below the median and 10·8 per cent at or below 0·5 MoM compared with 41·9 and 1·4 per cent of controls. These differences were even more striking when the gestational age was < 18 weeks compared with ⩾ 18 weeks. No such association was seen for other chromosome abnormalities including trisomy 18,45,X and mosaics, 47,XXY, 47,XXX, and other structural abnormalities and triploidy, even when high levels due to defects such as omphalocele and cystic hygroma were excluded. All cases of trisomy 13 and 80 per cent with 47,XYY had AF-AFP levels above the median. Selection of cases for karyotyping by a low level of AF-AFP would clearly fail to detect aneuploidies other than Down syndrome and is not recommended. A possible weak association between low maternal serum (MS) and AF-AFPs in Down syndrome was most evident at < 18 weeks, suggesting that MS screening between 16 and 18 weeks may be the most informative time. 相似文献
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During one year, five second trimester fetuses with cystic hygromata and varying degrees of oedema presented to the authors from hospitals in the West of Scotland. Two fetuses had 45X karyotypes, one each had 47XY+21 and 47XX+18 karyotypes, and the fifth had a normal 46XY karyotype. Fetal oedema detectable by ultrasound, affecting particularly the back of the neck, may be a commoner manifestation of several aneuploid syndromes than has hitherto been recognized. 相似文献
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Long-term monitoring data show that hard coral cover on the Great Barrier Reef (GBR) has reduced by >70 % over the past century. Although authorities and many marine scientists were in denial for many years, it is now widely accepted that this reduction is largely attributable to the chronic state of eutrophication that exists throughout most of the GBR. Some reefs in the far northern GBR where the annual mean chlorophyll a (Chl a) is in the lower range of the proposed Eutrophication Threshold Concentration for Chl a (~0.2–0.3 mg m−3) show little or no evidence of degradation over the past century. However, the available evidence suggests that coral diseases and the crown-of-thorns starfish will proliferate in such waters and hence the mandated eutrophication Trigger values for Chl a (~0.4–0.45 mg m−3) will need to be decreased to ~0.2 mg m−3 for sustaining coral reef communities. 相似文献
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In situ trampling occurred under experimental conditions to quantify the differences in the responses to anthropogenic trampling
in four dominant species of Hawaiian corals, Porites compressa, Porites lobata, Montipora capitata, and Pocillopora meandrina. Trampling was simulated daily for a period of nine days at which time further breakage was minimal. Forty treatment colonies
produced 559 fragments. Trampling was followed by an 11-month recovery period.
Coral colony and fragment mortality was low. All four species were highly tolerant of inflicted damage, suggesting that some
species of corals can withstand limited pulse events that allow time for recovery.
Growth rates following trampling were significantly lower in the treatment groups for three of the four species. This study
demonstrated that very few trampling events can produce significant changes in growth even after a long recovery period.
Survivorship of fragments is clearly size- and species-dependent in M. capitata and P. compressa. Smaller fragments (<5 cm) had higher mortality than larger fragments (>5 cm). High breakage rates for M. capitata and P. compressa are consistent with the nearshore, low-energy regions they inhabit—the same environment frequented by skin divers and waders.
Mechanical tests were conducted to determine tensile and compressive strengths. Pocillopora meandrina exhibited the strongest skeletal strength, followed in decreasing order by Porites lobata, Porites compressa, and Montipora capitata. The skeletal strength obtained from the experiments correlate with the wave energy present in the environments in the regions
they inhabit, suggesting that structural strength of corals is an adaptive response to hydraulic stress. 相似文献
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Nuchal translucency (NT) is the sonographic appearance of a subcutaneous collection of fluid behind the fetal neck. The measurement of fetal NT thickness at the 11–14-week scan has been combined with maternal age to provide an effective method of screening for trisomy 21; for an invasive testing rate of 5%, about 75% of trisomic pregnancies can be identified. When maternal serum free-β human chorionic gonadotrophin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) at 11–14 weeks are also taken into account, the detection rate of chromosomal defects is about 90%. Increased NT can also identify a high proportion of other chromosomal abnormalities and is associated with major defects of the heart and great arteries, and a wide range of skeletal dysplasias and genetic syndromes. In monochorionic twins, discordancy for increased NT is an early marker of twin-to-twin transfusion syndrome (TTTS). As with the introduction of any new technology into routine clinical practice, it is essential that those undertaking the 11–14-week scan are adequately trained and their results are subjected to rigorous audit. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
40.
Lorraine Dugoff 《黑龙江环境通报》2002,22(4):316-320
The advances in ultrasound technology have made it possible to identify fetal structural abnormalities and genetic syndromes in the first trimester. First trimester prenatal diagnosis of fetal central nervous system, renal, gastrointestinal, cardiac, and skeletal abnormalities is reviewed. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献