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Hsiu-Huei Peng Tzu-Hao Wang Ding-Wei Hsueh Shuenn-Dyh Chang Yung-Kuei Soong 《黑龙江环境通报》2005,25(6):470-474
We present a pregnant woman with a fetus prenatally diagnosed as 46, XY,der(4) t(4;12) (q35.1; q21.2). This defect resulted from the unbalanced segregation of a paternal balanced translocation, t(4;12) (q35.1; q21.2). Prenatal ultrasound revealed borderline ventriculomegaly, a thick nuchal fold, pericardial effusion, arthrogryposis, a single umbilical artery, and micropenis. Fluorescence in situ hybridization (FISH) with whole chromosome painting probe and microarray-based comparative genomic hybridization analysis further confirmed chromosomal gain of terminal 12q. The woman had her pregnancy terminated at 20 weeks of gestational age. When compared with previously reported cases, the proband had characteristics common to the phenotypes of partial trisomy 12q, including an abnormal facial appearance and multiple anomalies. Additionally, this case had previously unreported phenotypes, such as arthrogryposis, a single umbilical artery, and a micropenis. Regarding the outcome of partial trisomy 12q, the fetuses carrying trisomies distal to 12q24 have a good chance of extended postnatal survival. In contrast, the cases with trisomies involving a larger amount of 12q likely die prenatally or within a few days after birth. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
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Chromosomal aberrations and DNA damage in human populations exposed to the processing of electronics waste 总被引:1,自引:0,他引:1
Qiang Liu Jia Cao Ke Qiu Li Xu Hong Miao Guang Li Fei Yue Fan Yong Cheng Zhao 《Environmental science and pollution research international》2009,16(3):329-338
Background, aim, and scope It has been known that the pollutants of electronic wastes (E-wastes) can lead to severe pollution to the environment. It
has been reported that about 50% to 80% of E-wastes from developed countries are exported to Asia and Africa. It has become
a major global environmental problem to deal with ‘E-wastes’. E-waste recycling has remained primitive in Jinghai, China.
This not only produces enormous environmental pollution but also can bring about toxic or genotoxic effects on the human body,
threatening the health of both current residents and future generations living in the local environment. The concentration
of lead in the blood of children in the E-waste polluted area in China is higher than that of the control area. But little
is known about the cytogenetic effect to human beings caused by the pollution of E-wastes. In the present study, experiments
have been performed to investigate the genetics of permanent residents of three villages with numerous E-waste disposal sites
and to analyze the harmful effects of exposure to E-wastes.
Materials and methods In total, 171 villagers (exposed group) were randomly selected from permanent residents of three villages located in Jinghai
County of Tianjin, China, where there has been massive disposal of E-wastes. Thirty villagers were selected from the neighboring
towns without E-waste disposal sites to serve as controls. Chromosomal aberrations and cytokinesis blocking micronucleus were
performed to detect the cytogenetic effect, dic + r (dicentric and ring chromosome), monomer, fragments (acentric fragments,
minute chromosomes, and acentric rings), translocation, satellite, quadriradial, total aberrations, and micronuclear rate
were scored for each subject. DNA damage was detected using comet assay; the DNA percentage in the comet tail (TDNA%), tail
moment (TM), and Olive tail moment (OTM) were recorded to describe DNA damage to lymphocytes.
Results The total chromosome aberration rates (5.50%) and micronuclear rates (16.99%) of the exposure group were significantly higher
than in the control group (P = 0.000). The percentage of DNA in the comet tail, tail moment, and Olive tail moment detected by comet assay showed that
there was a significant difference in DNA damage in the exposure group (P = 0.000). The chromosome aberration, micronucleus rate, and DNA damage observed in women were significantly higher than those
in men. Chromosome aberration and micronuclear rates of both smokers and non-smokers in the exposure group are obviously higher
than that in the control group (P = 0.000).
Discussion The use of outdated (and unsafe) ways to deal with E-wastes can lead to exposure to a variety of substances harmful to human
health. The components of pollution may enter the human body through the air, drinking water, and food chain to damage human
genetic material, resulting in genomic instability. The rates of chromosomal aberration, micronucleus formation, and the degree
of DNA damage in women in the group exposed to electronic waste were significantly higher than in men. The reason for this
may be concerned with the traditional lifestyle of the local residents or the difference of sensitivity to the exposure to
E-wastes or any others. Further investigations are needed to provide evidence to demonstrate this.
Conclusions Here, we report the obviously cytogenetic toxicity to the exposure population by the E-waste pollution for the first time.
E-waste pollution may be a potential agent of genetic mutation, and may induce cytogenetic damage within the general population
exposed to the pollution. These findings need to be considered, and steps should be taken to protect the current population
and future generations from the effects of pollution with E-wastes.
Recommendations and perspectives The above results remind us that the impact of E-waste recycling on environmental quality of Jinghai should be evaluated soon.
Moreover, it is urgent for the government to prohibit E-waste import and its processing by outdated ways. The future studies
such as pollutant details of drinking water, air, and soil in the area as well as epidemiological investigations on the harmful
effect to children must be performed eagerly. All the data available do provide a compelling case for immediate action in
both countries to address workplace health and safety and waste management.
Qiang Liu and Jia Cao contributed equally to this study and share the first authorship. 相似文献
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Petroleum and derivatives have been considered one of the main environmental contaminants. Among petroleum derivatives, the volatile organic compounds benzene, toluene, ethylbenzene and xylene (BTEX) represent a major concern due to their toxicity and easy accumulation in groundwater. Biodegradation methods seem to be suitable tools for the clean-up of BTEX contaminants from groundwater. Genotoxic and mutagenic potential of BTEX prior and after biodegradation process was evaluated through analyses of chromosomal aberrations and MN test in meristematic and F1 root cells using the Allium cepa test system. Seeds of A. cepa were germinated into five concentrations of BTEX, non-biodegraded and biodegraded, in ultra-pure water (negative control), in MMS 4 × 10−4 M (positive control) and in culture medium used in the biodegradation (blank biodegradation control). Results showed a significant frequency of both chromosomal and nuclear aberrations. The micronucleus (MN) frequency in meristematic cells was significant for most of tested samples. However, MN was not present in significant levels in the F1 cells, suggesting that there was no permanent damage for the meristematic cell. The BTEX effects were significantly reduced in the biodegraded samples when compared to the respective non-biodegraded concentrations. Therefore, in this study, the biodegradation process showed to be a reliable and effective alternative to treat BTEX-contaminated waters. Based on our results and available data, the BTEX toxicity could also be related to a synergistic effect of its compounds. 相似文献
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José Delcán María Orera Rafael Linares Dolores Saavedra Angustias Palomar 《黑龙江环境通报》2004,24(8):635-637
We report a 16-week-gestation foetus obtained by voluntary abortion after prenatal diagnosis, in which a ring chromosome 22 was observed with deletion of the 22q13.3 region. A prenatal study of the amniotic fluid by standard chromosome technique with G bands and FISH (fluorescence in situ hybridisation) was performed. After the abortion, the anatomopathological study of the obtained foetus was carried out. Morphological and histological analysis of the foetus did not reveal severe physical abnormalities, although alterations of the nervous system were observed consisting of corpus callosum, fornix and septum pellucidum agenesia. It could be that the genes in this region that were involved in the development of the central nervous system were responsible for the alterations found in the morphological study. The wide range of manifestations observed in patients with this cytogenetic alteration is probably due to size differences in the deleted region. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献