Prenatal ultrasound diagnosis of frontonasal dysplasia

We report a case of prenatal ultrasound diagnosis of frontonasal dysplasia. This represents a very rare disorder involving the face (hypertelorism, median cleft lip, absence of the nasal tip) and often the central nervous system (CNS) (cranium bifidum occultum, ethmoidal cephalocele, agenesis of the corpus callosum). Although several of the typical anomalies are diagnosable by ultrasound in utero (hypertelorism, median cleft lip, anterior cephalocele), very few cases have been reported prenatally, the present being only the third. In the present case, hemimegalencephaly is first reported among the anomalies possibly associated with frontonasal dysplasia. The diagnosis was made at 22 weeks' gestation and was confirmed by necropsy following termination of pregnancy. Copyright © 2002 John Wiley & Sons, Ltd.     

三生共赢:可持续发展的根本目标与行为准则

明确可持续发展的行为目标。制定相应的评价准则，是可持续发展思想从理念探讨向实践操作延伸的必由之路，也是进行社会行为选择的依据。在系统分析生活、生产与生态之间的关系后，提出应将“生活水平不断提高，生产能力不断增长和生态环境不断改善”(简称“三生共赢”)作为可持续发展的行为目标和评价准则，并从理论上对这一命题进行了阐述。     

Using many-objective trade-off analysis to help dams promote economic development,protect the poor and enhance ecological health

Allocating water to different uses implies trading off the benefits perceived by different sectors. This paper demonstrates how visualising the trade-offs implied by the best performing water management options helps balance water use benefits and find sustainable solutions. The approach consists of linking a water resources model that can simulate many management policies and track diverse measures of system performance, to a many-objective evolutionary optimisation algorithm. This generates the set of Pareto-optimal management alternatives for several simultaneous objectives. The relative performance of these efficient management alternatives is then visualised as trade-off curves or surfaces using visual analytic plots. Visually assessing trade-offs between benefits helps select policies that achieve a decision-maker-selected balance between different metrics of system performance. We apply this approach to a multi-reservoir water resource system in Brazil's semi-arid Jaguaribe basin where current water allocation procedures favour sectors with greater political power and technical knowledge. The case study identifies promising reservoir operating policies by exploring trade-offs between economic, ecological and livelihood benefits as well as traditional hydropower generation, irrigation and water supply. Results show optimised policies can increase allocations to downstream uses while increasing median land availability for the poorest farmers by 25%.     

沿海发达地区土地利用研究新进展与方向

土地资源的短缺、质量退化与低效利用．已成为影响沿海发达地区生态安全与可持续发展的重要制约因素，也是土地利用管理与规划决策所面临的现实难题。我国沿海经济发达地区作为人地矛盾激化和经济快速转型背景下特殊的人文生态脆弱区，受到了包括地理学、生态学、经济学和社会学等多学科学者的密切关注，尤其是近10多年来在沿海土地利用变化及其效应研究方面取得了丰硕成果。主要以土地科学研究新方向和沿海地区经济社会发展态势为基本背景．从土地利用类型及其转换格局、驱动力因素辨识与驱动机制、土地利用转换的效应、区域土地可持续利用．以及土地利用优化配置与调控等方面，对沿海地区土地利用研究进行了初步梳理和评述，并指出今后应重视深化沿海发达地区土地利用研究的9个重点问题。     

Preimplantation genetic diagnosis using FISH for carriers of Robertsonian translocations: the Portuguese experience

Preimplantation genetic diagnosis (PGD) is an alternative to prenatal diagnosis for couples at risk of transmitting genetic disorders to their offspring. We present a fluorescence in situ hybridization (FISH) analysis of embryos obtained after seven PGD cycles in six couples with Robertsonian translocations and male factor infertility: 4 der(13;14), 1 der(14;21) and 1 der(15;21). Of 74 metaphase II (MII) injected oocytes, 61 (82.4%) fertilized normally and cleaved. Of these, 37/61 (60.7%) embryos were of high morphological quality with ≥6 blastomeres. After biopsy of 44 embryos at day 3 of development, seven degenerated, seven arrested in development and 30/44 (68.2%) evolved, of which 25/30 (83.3%) reached the morula/blastocyst stage. Analysis of biopsied blastomeres showed 23/44 (52.3%) of normal/balanced embryos, of which 15 (11 at the morula/blastocyst stage) were transferred in six cycles. One term pregnancy was achieved, which ended by cesarean section at 37 weeks of gestation, giving birth to two healthy newborn. Analysis of 49 embryos (excluding 12 inconclusive cases) showed a predominance of alternate segregation (38/49, 77.6%) over adjacent segregation (7/49, 14.3%), with one (2%) being a polyploid mosaic and three (6.1%) chaotic. Copyright © 2002 John Wiley & Sons, Ltd.     

平原地区洪灾风险评价的GIS方法研究 --以荆州6县市为例

平原地区因地势低平。水网发达而常遭到洪水的威胁。这种威胁既有来自过境洪水的洪灾．也有来自本地因暴雨引起的涝灾。如何考虑它们两者的相互影响以及洪水灾害的自然与社会经济属性，进行洪水风险评价是一个比较困难的问题。在地理信息系统软件ArcGIS8．1支持下，既考虑过境洪水与本地涝灾，也考虑承灾体的易损性(包括人口、交通线与经济)，还考虑抗灾能力，以GRID模块的地图代数作为运算手段，用AHP法确定因子的权重，建立了评估平原地区的洪灾风险的计算模型和评价方法，该模型运用于长江中游洪灾风险比较严重的地区——荆州地区的6县市．取得了比较好的效果。     

炮采放顶煤采空区自然发火的数值模拟应用

针对炮采放顶煤开采采空区容易发生自燃问题，基于漏风渗流方程、气体渗流一扩散-氧消耗方程，建立了采空区自然发火非稳定数值模型，采空区按非均质考虑，耗氧汇按煤矸氧化和瓦斯涌出稀释两方面综合考虑，用有限元数值方法联立求解模型。结合羊草沟矿实例，通过该矿自然发火后来的测试区的现场实测结果，拟合反演得到采空区煤的耗氧速度、瓦斯涌出强度和渗透特征参数，用确定的模型分析了前段出现自然发火的原因；描绘了炮采放顶煤开采时采空区冷却带、自燃带和窒息带等三带的形状，指出冒落压实的不均衡的非均质采空区，自燃点在偏人风一侧。用三带划分理论讨论了工作面参数（风量、推进度、控顶距）同自燃的量化关系，提出了从根本上预防采空区自然发火的途径与方法。     

鄂尔多斯周缘地震带中长期地震趋势估计

本文基于一定的地震资料,分别应用最大熵原理、贝努里概型以及计算地震复发周期的经验关系式,对鄂尔多斯周缘地震带进行了中强地震的中长期地震趋势估计。     

涪江上游滑坡相关因素研究

采用灰色系统理论的关联度分析方法，研究了涪江上游骨滑坡的主要形成条件及触发因素。结果显示，相对主同差是滑坡的主要形成条件，地震是滑坡的主要触发因素，此外，还对滑坡相关因素进行了相关显著性比较，评价了每项相关因素的其中所起的作用，最后讨论了灰色系统理论的关联度分析方法在滑坡研究中的利弊。