Clinical and toxicological data in Fenthion and omethoate acute poisoning

Abstract

This study paper reports on two cases of poisoning with the organophosphorus insecticides, fenthion and omethoate. The two victims were admitted in the Intensive Care Unit (ICU) a few hours after ingestion of the two insecticides. They received appropriate treatment for organophosphorous poisoning (gastric lavage, activated charcoal, atropine and pralidoxime) and supportive care. Both patients survived. Organophosphate blood levels were determined on admission (fenthion 2.9 (ig/ml, omethoate 1.6 Hg/ml) and during the hospitalisation and proved to be considerably high. Slow elimination rate of the poison already distributed in the body was indicated for both pesticides. The patient with omethoate poisoning remained clinically well (Glasgow Coma Scale : 15) and was discharged three days later. The patient with fenthion poisoning, who had also ingested 30 mg of bromazepam and 720 mg of oxetoron, developed cholinergic crisis six hours after admission and was intubated for 24 days, with concomitant complications.     

综合应急救援能力描述理论架构及提升内容研究

基于代数这一数学工具,该文创新建立综合应急救援能力描述理论架构,包括面向自然灾害、事故灾难、公共卫生、社会安全等灾种建立的救援灾害轴,面向村、社区、街道(镇)、区(县、市)、市、省等区域建立的救援区域轴,面向准备、响应、处置、保障、善后等时间建立的救援时间轴,由此构成综合应急救援能力描述三维坐标系;在此基础上,抽象出应急救援能力途径通用表达式模型。研究出综合应急救援能力提升内容,包括综合应急救援能力提升内容的通用表达式,以及应急救援能力提升内容的通用表格;基于这些研究成果,就可根据实际的救援灾害轴、救援区域轴、救援时间轴等实际情况,得出具体的综合应急救援能力提升内容。     

有机化合物生物富集因子的计算机预测研究

有机化合物在生物体内的富集,通常用生物富集因子(bioconcentration factor,简称BCF)来表达,这是化合物生态环境毒性评估的重要指标。为合理预测有机化合物是否易于生物富集,首先从美国环保局网站收集了624个具有不同BCF值的化合物,然后采用7种分子指纹结合5种机器学习方法(包括支持向量机、C4.5决策树、k最近邻法、随机森林法和朴素贝叶斯法),构建了化合物BCF的分类预测模型,所有模型均采用独立外部验证集进行验证。其中,使用Chemo Typer分子指纹结合支持向量机方法得到的二分类模型,整体预测准确度最好,达到了85.4%。通过采用信息增益、频率分析等方法,进一步确定了化合物中易于引起生物富集的关键子结构,包括芳基氯、二芳基醚、氯代烷烃等。研究中所用到的方法为有毒化学品的生态风险评价提供了良好可靠的预测工具。     

Studying developmental neurotoxic effects of bisphenol A (BPA) using embryonic stem cells

There is little to no toxicity information regarding thousands of chemicals to which people are exposed daily. In fact, of the 84,000 chemicals listed in the United States Toxic Substances Control Act Inventory, there is limited information available on their effects on neural development (Betts, 2010 and US EPA, 2015). The number of chemicals tested remains low due to the high cost of conducting multi-generational animal studies and the lack of alternative testing methods.     

Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells

The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems. In our group, we focus on stem cell toxicology due to the multitude of embryonic stem cell (ESC) properties which can be exerted in toxicity assays. In fact, ESCs can differentiate in culture to mimic embryonic development in vivo, or specifically to virtually any kind of somatic cells. Here, we used the toxicant Bisphenol A (BPA), a chemical known as a hazard to infants and children, and showed that our stem cell toxicology system was able to efficiently recapitulate most of the toxic effects of BPA previously detected by in vitro system or animal tests. More precisely, we demonstrated that BPA affected the proper specification of germ layers during our in vitro mimicking of the embryonic development, as well as the establishment of neural ectoderm and neural progenitor cells.     

安全生产与经济社会发展关系理论研究

对美、英、加、日、澳等发达国家的安全生产状况近百年的统计数据进行了分析研究,发现大都经历了从事故频发到达高峰.逐步下降到平稳发展的"驼峰"过程,安全生产状况与经济社会发展阶段存在着相互制约、相互影响的联系,这是建立安全生产状况与经济发展水平的理论模型的事实依据.安全生产状况随经济社会发展而呈现出阶段性的变化趋势.影响一个国家的职业安全健康水平的直接原因有经济上的(安全投入)、科学技术方面、管理制度方面以及教育文化水平方面的,其中经济发展水平是各种原因的根本.重点揭示了安全生产与经济社会发展关系的内在规律,建立了相应的理论模型.并把所建立的理论模型应用到我国的煤矿安全领域.理论模型与实际统计数据基本吻合.     

环境质量评价模糊集理论与模式研究

探讨了模糊集理论方法对环境质量评价的可行性，以大气环境质量评价为例，叙述了这种方法的研究程序及计算步骤。研究表明，采用模糊集理论方法对大气环境质量进行评价，结果结果合理，方法可行，有一定的参考价值。     

THE CASE FOR DIRECT MEASUREMENT OF ENVIRONMENTAL RESPONSE TO HAZARDOUS MATERIALS1

ABSTRACT: Direct measurement of response thresholds of complex biological systems to toxic chemicals is now possible using microcosms and other simulation techniques. Extrapolation to no-observable response using application factors and data from single species toxicity tests is less precise than direct measurements.     

TOXIC EFFECTS OF PETROLEUM AND SHALE JP-4 AND JP-8 AVIATION FUELS ON FATHEAD MINNOWS1

ABSTRACT: Static 96-hour median lethal concentrations were determined for the water-soluble fraction (WSF) of both petroleum-derived and shale-derived avaiation fuels (JP-4 and JP-8) using fathead minnows. JP-8 was more toxic than JP-4 except for one shale JP-4 sample that was as toxic as the JP-8. Petroleum and shale JP-8 were similar in toxicity. The toxicity of shale JP-4 was less clear. Shale JP-4 from three vendor sources revealed differing toxicity values. One shale JP-4 sample was more toxic and one less toxic than its petroleum analogue, with the third being equally toxic. Toxicity of the fuels may be enhanced by compounds in the WSF that correspond to chemicals containing 10 or more carbon atoms.