Integrated testing and intelligent assessment—new challenges under REACH

BACKGROUND, AIM AND SCOPE: Due to a number of drawbacks associated with the previous regime for the assessment of new and existing chemicals, the European Union established a new regulation concerning the registration, evaluation, authorisation and restriction of chemicals (REACH). All relevant industrial chemicals must now be assessed. Instead of the authorities, industry itself is responsible for the risk assessment. To achieve better and more efficient assessments while reducing animal testing, all information-standard, non-standard and non-testing-has to be used in an integrated manner. To meet these challenges, the current technical guidance documents for risk assessment of new and existing chemicals had to be updated and extended considerably. This was done by experts in a number of REACH Implementation Projects. This paper presents the most relevant results of the expert Endpoint Working Group on Aquatic Toxicity in order to illustrate the change of paradigm in the future assessment of hazards to the aquatic environment by chemical substances. MAIN FEATURES AND CHALLENGES: REACH sets certain minimum data requirements in order to achieve a high level of protection for human health and the environment. It encourages the assessor to use alternative information instead of or in addition to standard one. This information has to be equivalent to the standard information requirement and adequate to draw overall conclusions with respect to the regulatory endpoints classification and labelling, persistent, bioaccumulative and toxic (PBT) assessment and predicted no-effect concentrations (PNEC) derivation. The main task of the expert working group was to develop guidance on how to evaluate the toxicity of a substance based on integration of information from different sources and of various degrees of uncertainty in a weight of evidence approach. INTEGRATED TESTING AND INTELLIGENT ASSESSMENT: In order to verify the equivalence and adequacy of different types of information, a flexible sequence of steps was proposed, covering characterisation of the substance, analysis of modes of action, identification of possible analogues, evaluation of existing in vivo and in vitro testing data as well as of QSAR results. Finally, all available data from the different steps have to be integrated to come to an overall conclusion on the toxicity of the substance. This weight of evidence approach is the basis for the development of integrated testing strategies (ITS), in that the available evidence can help to determine subsequent testing steps and is essential for an optimal assessment. Its flexibility helps to meet the different requirements for drawing conclusions on the endpoints classification and labelling, PNEC derivation as well as PBT assessment. The integration of all kinds of additional information in a multi-criteria assessment reduces the uncertainties involved with extrapolation to the ecosystem level. The weight of evidence approach is illustrated by practical examples. CONCLUSIONS AND PERSPECTIVES: REACH leads to higher challenges in order to make sound decisions with fewer resources, i.e. to move away from extensive standard testing to an intelligent substance-tailored approach. Expert judgement and integrated thinking are key elements of the weight of evidence concept and ITS, potentially leading to better risk assessments. Important sub-lethal effects such as endocrine disruption, which are not covered by the current procedure, can be considered. Conclusions have to be fully substantiated: Risk communication will be an important aspect of future assessments.     

中国低碳城市发展模式与行动策略

建设低碳城市是促进节能减排和经济社会持续发展的重要战略举措,成为未来城市发展的重要导向和路径选择.从低碳城市发展重要性和紧迫性入手,在立足基本国情的基础上设计了低碳城市发展愿景.结合城市化快速推进预期和经济社会发展需求,分阶段提出了低碳城市发展目标.从总体模式、指导理念、基本思路、主要领域等对我国低碳城市发展模式进行了构想.在此基础上,提出我国低碳城市发展的实施步骤和行动策略.研究认为,我国低碳城市发展模式应选择“C”模式,以低碳发展为主导方向,以节能减排为发展方式,以低碳生产和低碳生活为主要方法.按照控源、减碳、增汇的基本思路,依靠理念创新、技术创新和制度创新,在低碳产业、低碳能源、低碳技术以及低碳生活等领域,通过构建低碳城市规划理论框架、建立低碳城市评价标准和体系、加快相关政策规章与制度建设、开展城市碳交易试点以及加强监督指导等措施,立足国情、统筹兼顾,分步骤、分阶段有序推进低碳城市发展.     

Comparison of the Vegetation and Seed Bank on Hedge Banks of Different Ages in Brittany,France

The composition of the herbaceous cover and the seed bank of old and recent hedge banks in Brittany were studied and compared. Concentration method was used for seed bank samples. Grimes plant strategies were used to explain observed patterns. The analysis of the seed bank of these hedge banks showed that the species richness and diversity differed in relation to the date of construction of the hedge banks. The seed banks of recent hedge banks were richer and more diversified than those of old hedge banks. Differences in the floristic composition of the established plant cover between the recent and old hedge banks were determined by multivariate analyses. The species exclusively found in the seed bank and in the herb cover of recent hedge banks were mainly grassland species, whereas the species that only occurred on old hedge banks tended to be woodland species. The floristic composition of the two compartments (established vegetation and seed bank) was very different. A multivariate analysis revealed that the difference between the composition of the seed banks of recent and old hedge banks was less than that between the composition of the established vegetation and seed bank of hedge banks of the same age. Both seed bank and vegetation of recent hedge banks were dominated by ruderal species, whereas old hedge vegetation was dominated by stress-tolerant woodland species, indicating that mechanically constructed hedge banks may impose limitations on colonization by late woodland species.     

长江三角洲耕地资源态势与保护对策

长江三角洲是我国东部沿海经济最发达的地区,在全国占有十分重要的经济地位。随着经济的发展,资源与环境发生了严重的问题,特别是近年来耕地资源锐减,而后备耕地资源却短缺,人地人粮矛盾更加尖锐,已成为影响这一地区农业持续发展的重要因素。本文分析了这一地区的经济特点与耕地资源的变化态势,并提出了相应的耕地保护措施。首先,要严格控制非农用地,确保基本农田,其次要采用经济手段,建立保护耕地的经济机制;此外,还要     

Methane fluxes from artificial wetlands: A global appraisal

Methane emissions make an important contribution to the enhanced greenhouse effect, emissions from rice growing being one of its major anthropogenic sources. The estimation of global fluxes of methane from rice and from coarse fiber production depends on extrapolating observed data across countries and agroclimatic zones: the estimates are therefore imprecise. We present a revised estimate of global emissions of 96 Tg CH₄/yr, given 1991 rice areas, and 1991 production data for those tropical coarse fibers that also produce methane under anaerobic conditions. This is higher than many previous studies, which systematically underestimated the fluxes from tropical countries. As the world's population increases, the demand for rice will rise. This demand can only be satisfied through greater rice production, either by bringing new areas into rice growing or by using the present area more intensively. Strategies based on improved water management and fertilizer use will allow increased rice production and yields and reduce the methane flux per unit or rice production.     

生态城市建设的研究

探讨了生态城市的概念、内涵和特征，从城市生态系统的结构、功能和协调度三个方面构建城市生态评价指标体系，应用层次分析法(AHP)对北京、上海、成都、西安、兰州、乌鲁木齐6个城市的生态状况进行定量分析，提出了城市生态建设的对策。     

发展我国森林生态旅游的对策思考

作者以生态旅游理论为基础，分析了我国森林生态旅游的发展状况，并以加入WTO为背景从中找出存在的问题，进而提出入世后推进我国森林生态旅游发展的对策。     

Revolution or inch-by-inch? Campaign approaches on climate change by environmental groups

Climate change is a significant environmental, social and environmental problem that has been identified by scientists in consensus internationally. The Australian Government’s response is considered by environmental non-government organisations (NGOs) to be inadequate. NGOs are ‘change agents’ of society, and in this role they are agitating to influence political decision-making on climate change response. This paper outlines the campaign strategies being used by Australian NGOs to attract public and political attention to the issue of climate change. Using seven NGOs as case studies, the archival materials of these organisations were accessed and analysed. Current academic and other literature also was used to reflect on their effectiveness. Four campaign themes and, within these, fifteen activities were identified. The results indicate that the notion of whether NGOs are undertaking an ‘revolutionary’ or ‘incremental’ approach, or any other narrow strategic approach put forward by various scholars is too simple for analysing campaigns: none of the NGOs appear to intentionally favour one type of strategy. The question raised by this finding is whether the NGOs’ current ‘multi-strategic’ approach is effective. This research contributes to filling the information gap with regard to NGO campaign strategies on environmental issues, and highlights the need for further research.     

莆田市气象灾害及减灾对策研究

根据近17年的莆田市气候影响评价资料,结合实地调查,对莆田市台风、暴雨、冰雹、干旱、寒潮等主要气象灾害的基本特点进行了分析。研究表明,近17年莆田市危害最大的气象灾害是台风灾害,其次为洪涝灾害,揭示了几种主要气象灾害之间的相互关系,并提出相应的减灾对策。     

HIV risk and prevention in emergency-affected populations: a review

While basic guidelines on HIV prevention in emergencies have been available for several years, international agencies involved in the provision of health services have not placed sufficient priority on the prevention of the human immune deficiency virus (HIV) and other sexually transmitted infections (STIs) in complex emergencies. This paper reviews the factors that may increase the risk of HIV transmission in populations affected by complex emergencies and outlines recommendations for research and programmes. Research into the most appropriate methods of carrying out HIV surveillance and interventions in these settings is needed. In the post-emergency phase programmes need to be far more extensive than those offered under the Minimal Initial Services Package (MISP). While the potential for stigmatization represents an important constraint, there is a need to prioritize HIV/STI interventions in order to prevent HIV transmission in emergency-affected populations themselves, as well as to contribute to regional control of the epidemic.