● B[a]P, nicotine and phenanthrene molecules altered the secondary structure of Aβ42. ● β-content of the peptide was significantly enhanced in the presence of the PAHs.● Nicotine made stable cluster with Aβ42 peptide via hydrogen bonds. ● Phenanthrene due to its small size, interfered with the Aβ42 monomer more strongly. Recent studies have correlated the chronic impact of ambient environmental pollutants like polycyclic aromatic hydrocarbons (PAHs) with the progression of neurodegenerative disorders, either by using statistical data from various cities, or via tracking biomarkers during in-vivo experiments. Among different neurodegenerative disorders, PAHs are known to cause increased risk for Alzheimer’s disease, related to the development of amyloid beta (Aβ) peptide oligomers. However, the complex molecular interactions between peptide monomers and organic pollutants remains obscured. In this work, we performed an atomistic molecular dynamics study via GROMACS to investigate the structure of Aβ42 peptide monomer in the presence of benzo[a]pyrene, nicotine, and phenanthrene. Interestingly the results revealed strong hydrophobic, and hydrogen-bond based interactions between Aβ peptides and these environmental pollutants that resulted in the formation of stable intermolecular clusters. The strong interactions affected the secondary structure of the Aβ42 peptide in the presence of the organic pollutants, with almost 50 % decrease in the α-helix and 2 %–10 % increase in the β-sheets of the peptide. Overall, the undergoing changes in the secondary structure of the peptide monomer in the presence of the pollutants under the study indicates an enhanced formation of Aβ peptide oligomers, and consequent progression of Alzheimer’s disease. 相似文献
Pressures on water resources due to changing climate, increasing demands, and enhanced recognition of environmental flow needs result in the need for hydrology information to support informed water allocation decisions. However, the absence of hydrometric measurements and limited access to hydrology information in many areas impairs water allocation decision‐making. This paper describes a water balance‐based modeling approach and an innovative web‐based decision‐support hydrology tool developed to address this need. Using high‐resolution climate, vegetation, and watershed data, a simple gridded water balance model, adjusted to account for locational variability, was developed and calibrated against gauged watersheds, to model mean annual runoff. Mean monthly runoff was modeled empirically, using multivariate regression. The modeled annual runoff results are within 20% of the observed mean annual discharge for 78% of the calibration watersheds, with a mean absolute error of 16%. Modeled monthly runoff corresponds well to observed monthly runoff, with a median Nash–Sutcliffe statistic of 0.92 and a median Spearman rank correlation statistic of 0.98. Monthly and annual flow estimates produced from the model are incorporated into a map‐ and watershed‐based decision‐support system referred to as the Northeast Water Tool, to provide critical information to decision makers and others on natural water supply, existing allocations, and the needs of the environment. 相似文献
Coastal catchments in British Columbia, Canada, experience a complex mixture of rainfall‐ and snowmelt‐driven contributions to flood events. Few operational flood‐forecast models are available in the region. Here, we integrated a number of proven technologies in a novel way to produce a super‐ensemble forecast system for the Englishman River, a flood‐prone stream on Vancouver Island. This three‐day‐ahead modeling system utilizes up to 42 numerical weather prediction model outputs from the North American Ensemble Forecast System, combined with six artificial neural network‐based streamflow models representing various slightly different system conceptualizations, all of which were trained exclusively on historical high‐flow data. As such, the system combines relatively low model development times and costs with the generation of fully probabilistic forecasts reflecting uncertainty in the simulation of both atmospheric and terrestrial hydrologic dynamics. Results from operational testing by British Columbia's flood forecasting agency during the 2013‐2014 storm season suggest that the prediction system is operationally useful and robust. 相似文献
In this work, an attempt has been made to harvest green energy from piezoelectric material using fluid flow in a conduit. Piezoelectric Energy Harvesting using Fluid Flow (PEHF) experimental model has been designed and the outputs obtained are compared with results obtained from simulations using ANSYS (computational fluid dynamics) and also with the mathematical modeling. The PEHF model has been utilized to analyze the effect of flow rate of water with reference to energy extracted. The full wave bridge rectifier and voltage doubler circuits have been used to obtain the direct current (DC) from the PEHF model. It is observed that the output obtained using experiments holds good in agreement with the results retrieved through simulations and mathematical results. The increase in flow rate of fluid leads to initially increase and then decrease in output of PEHF model as the maximum energy generated when flow rates (external force) matches with the frequency of excitation of the systems, i.e., at its resonance. The maximum energy output is generated at its resonance frequencies. It is observed that the full wave bridge rectifier circuit gives greater output as compared to a voltage doubler circuit. 相似文献
Concentrations of eight elements were measured in Chelonia mydas and Lepidochelys olivacea eggs collected along the Pacific coast of Panama. Manganese (Mn), iron (Fe), copper (Cu), zinc (Zn), arsenic (As), cadmium (Cd), and mercury (Hg) concentrations were similar to previous reports of these species from around the world, while lead (Pb) was lower than previous reports. Cd posed the highest health risk to people who regularly eat the eggs, with average consumption rates leading to target hazard quotients (THQ) of up to 0.35 ± 0.15. Our conclusions indicate that current turtle egg consumption in isolated, coastal Pacific communities may pose a health concern for young children, and that youth and young adults should limit their consumption of turtle eggs to reduce their total intake of nonessential metals. 相似文献
Objective: The lower extremity of the occupant represents the most frequently injured body region in motor vehicle crashes. Knee airbags (KABs) have been implemented as a potential countermeasure to reduce lower extremity injuries. Despite the increasing prevalence of KABs in vehicles, the biomechanical interaction of the human lower extremity with the KAB has not been well characterized. This study uses computational models of the human body and KABs to explore how KAB design may influence the impact response of the occupant's lower extremities.
Methods: The analysis was conducted using a 50th percentile male occupant human body model with deployed KABs in a simplified vehicle interior. The 2 common KAB design types, bottom-deploy KAB (BKAB) and rear-deploy KAB (RKAB), were both included. A state-of-the-art airbag modeling technique, the corpuscular particle method, was adopted to represent the deployment dynamics of the unfolding airbags. Validation of the environment model was performed based on previously reported test results. The kinematic responses of the occupant lower extremities were compared under both KAB designs, 2 seating configurations (in-position and out-of-position), and 3 loading conditions (static, frontal, and oblique impacts). A linear statistical model was used to assess factor significance considering the impact responses of the occupant lower extremities.
Results: The presence of a KAB had a significant influence on the lower extremity kinematics compared to no KAB (P <.05) by providing early restraint and distributing contact force on the legs during airbag deployment. For in-position occupants, the KAB generally tended to decrease tibia loadings. The RKAB led to greater lateral motion of the legs compared to the BKAB, resulting in higher lateral displacement at the knee joint and abduction angle change (51.2 ± 21.7 mm and 15° ± 6.0°) over the dynamic loading conditions. Change in the seating position led to a significant difference in occupant kinematic and kinetic parameters (P <.05). For the out-of-position (forward-seated) occupant, the earlier contact between the lower extremity and the deploying KAB resulted in 28.4° ± 5.8° greater abduction, regardless of crash scenarios. Both KAB types reduced the axial force in the femur relative to no KAB. Overall, the out-of-position occupant sustained a raised axial force and bending moment of the tibia by 0.8 ± 0.2 kN and 21.1 ± 8.7 Nm regardless of restraint use.
Conclusions: The current study provided a preliminary computational examination on KAB designs based on a limited set of configurations in an idealized vehicle interior. Results suggested that the BKAB tended to provide more coverage and less leg abduction compared to the RKAB in oblique impact and/or the selected out-of-position scenario. An out-of-position occupant was associated with larger abduction and lower extremity loads over all occupant configurations. Further investigations are recommended to obtain a full understanding of the KAB performance in a more realistic vehicle environment. 相似文献