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Shahid Parvez Glenn E. Rice Linda K. Teuschler Jane Ellen Simmons Thomas F. Speth Susan D. Richardson Richard J. Miltner E. Sidney Hunter III Jonathan G. Pressman Lillian F. Strader Gary R. Klinefelter Jerome M. Goldman Michael G. Narotsky 《环境科学学报(英文版)》2017,29(8):311-321
A method based on regression modeling was developed to discern the contribution of component chemicals to the toxicity of highly complex, environmentally realistic mixtures of disinfection byproducts(DBPs). Chemical disinfection of drinking water forms DBP mixtures.Because of concerns about possible reproductive and developmental toxicity, a whole mixture(WM) of DBPs produced by chlorination of a water concentrate was administered as drinking water to Sprague–Dawley(S–D) rats in a multigenerational study. Age of puberty acquisition,i.e., preputial separation(PPS) and vaginal opening(VO), was examined in male and female offspring, respectively. When compared to controls, a slight, but statistically significant delay in puberty acquisition was observed in females but not in males. WM-induced differences in the age at puberty acquisition were compared to those reported in S–D rats administered either a defined mixture(DM) of nine regulated DBPs or individual DBPs. Regression models were developed using individual animal data on age at PPS or VO from the DM study. Puberty acquisition data reported in the WM and individual DBP studies were then compared with the DM models. The delay in puberty acquisition observed in the WM-treated female rats could not be distinguished from delays predicted by the DM regression model, suggesting that the nine regulated DBPs in the DM might account for much of the delay observed in the WM. This method is applicable to mixtures of other types of chemicals and other endpoints. 相似文献
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Ghosh R Joad J Benes I Dostal M Sram RJ Hertz-Picciotto I 《Environment international》2012,39(1):96-102
Acute respiratory infections are common in children below 5 years and recent studies suggest a possible link with air pollution. In this study, we investigated the association between ambient nitrogen oxides (NOx) and bronchitis or upper airway inflammation.This longitudinal study was conducted in Teplice and Prachatice districts, Czech Republic. Children were followed from birth to 4.5 years of age. Data were compiled from medical records at delivery and at follow up, and from self-administered questionnaires from the same two time points. Air pollution monitoring data were used to estimate exposure over five different averaging periods ranging from three to 45 days prior to an episode. To quantify the association between exposure and outcome, while accounting for repeated measure correlation we conducted logistic regression analysis using generalized estimating equations.During the first 2 years of life, the adjusted rate ratio for bronchitis associated with interquartile increase in the 30-day average NOx was 1.31 [95% confidence interval (CI): 1.07, 1.61] and for two to 4.5 year olds, it was 1.23 (95% CI: 1.01, 1.49). The 14-day exposure also had stable association across both age groups: below 2 years it was 1.25 (95% CI: 1.06, 1.47) and for two to 4.5 years it was 1.21 (95% CI: 1.06, 1.39). The association between bronchitis and NOx increased with child's age in the under 2 years group, which is a relatively novel finding.The results demonstrate an association between NOx and respiratory infections that are sufficiently severe to come to medical attention. The evidence, if causal, can be of public health concern because acute respiratory illnesses are common in preschool children. 相似文献
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The National Forest Management Act (1976) specifies that multiresource inventories be conducted to provide baseline data for
development and, later, monitoring of national forest management plans. This mandate entails the most ambitious and complex
resource planning effort ever attempted. In this paper we evaluate the structure and use of current inventory-monitoring programs
and recommend a framework for gathering data to improve national forest planning. Current national guidelines are general
and provide only basic directions to forest-level planners. Forest inventories have traditionally concentrated on timber.
Although these inventories are often well designed, the questions we are now asking about forest resources have outgrown these
methods. Forest management is impeded by general confusion over definitions of resources and the interactions among them.
We outline a simple classification scheme that centers on identification of basic ecosystem elements that can be readily measured.
Furthermore, spatial and temporal scales must be considered in the design of inventory-monitoring programs. The concept of
ecological indicators is reviewed, and caution is advised in their use. Inventory-monitoring programs should be goal-directed
and based on as rigorous a statistical design as possible. We also review fundamental issues of variable selection, validation,
and sampling bias. We conclude by developing a flexible inventory-monitoring program that is designed to provide information
on individual characteristics of the environment, rather than being based on fixed definitions of resources. 相似文献
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本文系统分析现代灾害的特点;评述灾害研究及灾害学的历史与现状,预测其发展趋势;探讨灾害学的基本范畴,界定其学科体系的总体框架,对灾害研究及灾害学发展中的几个重要问题提出认识与建议。 相似文献
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气象灾害的研究和预防是野外职业安全卫生的一个重要领域 总被引:1,自引:0,他引:1
从事野外地质勘探的职工常常处于大自然环境中。自然环境灾害(气象灾害、地质灾害等)是造成地质勘探职业伤害的重要原因之一。在诸多的环境灾害中,又以气象灾害的危害最为突出。研究和预防气象灾害,是地质勘探安全卫生工作的重要内容。如果只研究人为职业伤害(一般工业安全卫生中的主要问题),而不研究环境灾害,特别是气象灾害所造成的事故和职业病,那是舍本求末。在地质勘探安全卫生领域中,研究气象灾害及其防护技术,既是保护野外作业职工安全和健康的需要,也是拓宽安全科学外延领域的有益探讨。 相似文献
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对区域性有害废物集中处理场的建设及管理等问题,提出了一系列相关的注意事项及处理办法;并从法律的角度给予明确的规定 相似文献
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