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Suksaeree Jirapornchai Maneewattanapinyo Pattwat Panrat Kamon Pichayakorn Wiwat Monton Chaowalit 《Journal of Polymers and the Environment》2021,29(10):3174-3184
Journal of Polymers and the Environment - In this study, solvent-cast polymeric films containing ionic liquid lidocaine/aspirin for transdermal patches were developed. Solvent-cast polymeric films... 相似文献
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Pichayakorn Wiwat Panrat Kamon Suksaeree Jirapornchai Taweepreda Wirach 《Journal of Polymers and the Environment》2022,30(3):925-937
Journal of Polymers and the Environment - The aim of this study was to investigate the feasibility of concentrated natural rubber latex (CNRL), a major polymer, blended with either... 相似文献
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Jirapornchai Suksaeree Phatipan Karnsopa Nannapat Wannaphruek Jessada Prasomkij Kamon Panrat Wiwat Pichayakorn 《Journal of Polymers and the Environment》2018,26(8):3216-3225
Many natural polymers with various chemical structures are used to prepare transdermal patches. Pectin is a one interesting type of polymer because it can control drug release when used in transdermal patches. In Thailand, the waste from durian fruit-hulls is a major problem for the environment. However, the pectin from it can be isolated under acid conditions and used to prepare transdermal patches for nicotine delivery which has not yet been reported. As the isolated pectin is a natural polymer, the film made from isolated pectin is a brittle; therefore, adding a low protein natural rubber latex (LPNRL) polymer was needed to increase its flexibility. The transdermal patches were amorphous and had Tg values ranging from 81.0 to 93.3 °C. Moisture uptake, swelling ratio, and erosion values of the patches were significantly decreased after addition of LPNRL, which resulted in low hydrophilicity. The in vitro release and permeation of nicotine depends on the hydrophilicity of the patches. The kinetic models for in vitro release and permeation of nicotine were Higuchi model and zero order, respectively. In conclusion, pectin isolated from fruit-hulls of Mon Thong durians is an effective polymer to control the release of nicotine. It also is an option that could solve the environmental problems caused by durian fruit-hulls waste. 相似文献
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Jirapornchai Suksaeree Phatipan Karnsopa Nannapat Wannaphruek Jessada Prasomkij Kamon Panrat Chaowalit Monton Wiwat Pichayakorn 《Journal of Polymers and the Environment》2018,26(9):3531-3539
Pectin is a natural biopolymer, and a major component of a complex heterogeneous polysaccharide found in the primary cell walls and middle lamella of plant tissues. This paper used pectin isolated from Cissampelos pareira (Krueo Ma Noy) leaves to prepare the matrix layer for nicotine transdermal patches. However, the patch was a brittle film, thus, deproteinized natural rubber latex (DNRL) was blended to improve flexibility of the patch. Here we present for the first time a preparation study exploring the suitability of isolated pectin blends to serve as drug carriers and the mechanism controlling the release patterns of nicotine. The hydrophilicity of the patches was found to decrease when increasing the DNRL ratio. Differential scanning calorimetry and X-ray diffraction experiments were used to characterize the interactions between the investigated drugs and the matrix polymers. In vitro studies showed that the isolated pectin blends were an effective matrix for controlled nicotine release. The release and permeation patterns of nicotine depend on the hydrophilicity of the patches. The kinetic models of nicotine were found to be a Higuchi model and zero order for in vitro release and skin permeation, respectively. 相似文献
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Pichayakorn Wiwat Maneewattanapinyo Pattwat Panrat Kamon Monton Chaowalit Suksaeree Jirapornchai 《Journal of Polymers and the Environment》2022,30(10):4479-4491
Journal of Polymers and the Environment - This work prepared oral strip-film for nicotine delivery using polyvinyl alcohol and polyvinylpyrrolidone as polymeric film and glycerin as a plasticizer.... 相似文献
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