Besprechungen

The Science of Nature -     

Bewertung der Umweltrelevanz von Arzneistoffen

Aim The aim of this work was to investigate, which human and veterinary pharmaceuticals are of high ecological relevance due to the input into the environment as well as with regard to the effects and behaviour in the environment. Furthermore, the state of knowledge concerning the ecologically relevant substances and the need of research was evaluated. Methods A two-step approach considering the criteria quantity of sold pharmaceuticals, concentrations, effects and fate in the environment was developed to identify the pharmaceuticals of potential ecological relevance. In a second step the identified individual substances and groups of substances were considered in more detail concerning metabolism, environmental behaviour and ecological effects. Results In a first step 29 out of approximate 2,700 licensed human pharmaceuticals and seven substances as well as three substance groups used in veterinary medicine were identified as potentially ecologically relevant. The detailed assessment in a second step lead to the conclusion, that of the human pharmaceuticals 9 substances as well as two substance groups concerning the environmental behaviour and seven substances concerning the effects are of high environmental relevance. Concerning the environmental behaviour six out of seven veterinary pharmaceuticals as well as three substance groups and only three substances concerning the ecological effects were classified as relevant for the environment. Discussion By means of the presented method it was possible to limit the scope of a wide spectrum of pharmaceuticals, so that a detailed assessment of only relevant active agents was possible. Nevertheless, it is a precondition that investigations concerning the occurrence, fate and effects of the individual compounds in the environment have been already carried out and published in the literature. Conclusions The method is suitable for a comprehensive assessment of the ecological relevance of pharmaceuticals, but for a lot of human and veterinary pharmaceuticals the data available in the literature are insufficient. Recommendations For a final extensive assessment of the environmental relevance for some of the human and veterinary pharmaceuticals more studies are necessary. Especially data concerning the environmental behaviour in water and soils, data from long-term-studies for the assessment of ecological effects and data concerning metabolites and mixtures of pharmaceutical compounds are lacking.