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Alessandro Ghidini MD Manuel Alvarez Gittel Silverberg Eugene Ainbender Charles J. Lockwood 《黑龙江环境通报》1994,14(7):599-602
Congenital nephrosis is an autosomal recessive disorder requiring neonatal renal transplant for survival. The postnatal diagnosis rests upon the electron microscopic evaluation of the epithelial foot processes and basal membrane of the glomeruli. The prenatal diagnosis can be suspected in the presence of a positive family history with an amniotic fluid (AF) alpha-fetoprotein level greater than 5 standard deviations (SD) above the population mean accompanied by a negative AF acetylcholinesterase, absent haemoglobin F, and an unremarkable fetal sonographic examination. We reviewed our series of seven cases of congenital nephrosis fulfilling the above criteria; four cases had negative family histories, and in two cases the diagnosis of congenital nephrosis was further supported by the presence of elevated AF albumin concentrations. We conclude that (1) the prenatal diagnosis of congenital nephrosis is feasible in a low-risk population, and (2) an elevated AF albumin concentration may represent an additional marker for the diagnosis of congenital nephrosis, even though false-negative results have been reported. 相似文献
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In vivo observations in laboratory mesocosms and aquaria, accompanied with in situ photographic surveys, have shown that the burrowing shrimp Calocaris templemani has a significant impact on bottom sediment dynamics and geochemistry in the St. Lawrence Estuary. This burrowing shrimp establishes and maintains complex semi-permanent burrows made up of several interconnected, ‘U-shaped’ galleries with generally four or more openings to the sediment surface. In the Estuary, at 345 m depth, Calocaris average density was estimated at 3.4 individuals m?2. Observed individual burrows reached a maximum volume of 0.54 L. C. templemani displaces this volume of mostly anoxic sediments from the subsurface layers (down to 15 cm) to the sediment surface, thereby obscuring some of the natural stratification patterns. With an estimated turnover rate of about 8 L m?2 year?1 of sediment, our calculations suggest that over a period of about 18.75 years, all the sediment to a depth of 15 cm will have been reworked by C. templemani alone. 相似文献
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