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Goonnapa Fucharoen Warunee Tungwiwat Thawalwong Ratanasiri Kanokwan Sanchaisuriya Supan Fucharoen 《黑龙江环境通报》2003,23(5):393-396
In order to provide a noninvasive prenatal diagnosis of the hemoglobin E (Hb E) related disorder, we have evaluated the possibility of identifying the fetal βE-globin gene in maternal plasma. The analysis was performed during 8 to 18 weeks of gestation using DNA extracted from 200 µL of plasma from pregnant women whose husbands carried Hb E. The βE-globin mutation in maternal plasma was detected by a nested PCR amplification followed by the Mnl I restriction analysis. The result was compared with that of routine analysis of the CVS specimens. Among the five pregnant women examined, the fetal βE-globin gene was identified in maternal plasma in three of them and the result was completely concordant with the conventional CVS analysis. This simple noninvasive prenatal detection of the fetal βE-globin gene should prove useful in a prevention and control program of Hb E/β-thalassemia in countries where the βE-globin gene is prevalent. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
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Theera Tongsong Pimlak Charoenkwan Pannee Sirivatanapa Chanane Wanapirak Wirawit Piyamongkol Supatra Sirichotiyakul Kasemsri Srisupundit Fuanglada Tongprasert Suchaya Luewan Thawalwong Ratanasiri Ratana Komwilaisak Piyamas Saksiriwuttho Chutawadi Vuthiwong Peerapun Punpuckdeekoon Prisana Panichkul Wibool Rueangchainikhom Jirawat Choowong Nawaporn Orungrote Sravuth Sarapak Ekachai Kovavisarach Prapon Jaruyawongs Thitinan Tansathit Podjanee Phadungkiatwattana Jittima Rujiwetpongstorn Ounjai Kor-anantakul Chitkasaem Suwanrath Tharangrut Hanprasertpong Savitree Pranpanus 《黑龙江环境通报》2013,33(5):477-483
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