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S. V. M. Maharaj W. H. Orem C. A. Tatu H. E. Lerch III D. N. Szilagyi 《Environmental geochemistry and health》2014,36(1):1-17
The Pliocene lignite hypothesis is an environmental hypothesis that has been proposed to explain the etiology of Balkan endemic nephropathy (BEN). Aqueous leaching experiments were conducted on a variety of coal samples in order to simulate groundwater leaching of organic compounds, and to further test the role of the Pliocene lignite hypothesis in the etiology of BEN. Experiments were performed on lignite coal samples from endemic BEN areas in Romania and Serbia, and lignite and bituminous coals from nonendemic regions in Romania and the USA. Room temperature, hot water bath, and Soxhlet aqueous extraction experiments were conducted between 25 and 80 °C, and from 5 to 128 days in duration. A greater number of organic compounds and in higher concentrations were present in all three types of leaching experiments involving endemic area Pliocene lignite samples compared to all other coals examined. A BEN causing molecule or molecules may be among phenols, PAHs, benzenes, and/or lignin degradation compounds. The proposed transport pathway of the Pliocene lignite hypothesis for organic compound exposure from endemic area Pliocene lignite coals to well and spring drinking water, is likely. Aromatic compounds leached by groundwater from Pliocene lignite deposits in the vicinity of endemic BEN areas may play a role in the etiology of the disease. A better understanding of organic compounds leached by groundwater from Pliocene lignite deposits may potentially lead to the identification and implementation of effective strategies for the prevention of exposure to the causative agent(s) for BEN, and in turn, prevention of the disease. 相似文献
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Nikola M. Pavlović Vuk Maksimović Jelena Dragišić Maksimović William H. Orem Calin A. Tatu Harry E. Lerch Joseph E. Bunnell Emina N. Kostić Diana N. Szilagyi Virgil Paunescu 《Environmental geochemistry and health》2013,35(2):215-226
Aristolochic acids (AAs) are nephrotoxic and carcinogenic derivatives found in several Aristolochia species. To date, the toxicity of AAs has been inferred only from the effects observed in patients suffering from a kidney disease called “aristolochic acid nephropathy” (AAN, formerly known as “Chinese herbs nephropathy”). More recently, the chronic poisoning with Aristolochia seeds has been considered to be the main cause of Balkan endemic nephropathy, another form of chronic renal failure resembling AAN. So far, it was assumed that AAs can enter the human food chain only through ethnobotanical use (intentional or accidental) of herbs containing self-produced AAs. We hypothesized that the roots of some crops growing in fields where Aristolochia species grew over several seasons may take up certain amounts of AAs from the soil, and thus become a secondary source of food poisoning. To verify this possibility, maize plant (Zea mays) and cucumber (Cucumis sativus) were used as a model to substantiate the possible significance of naturally occurring AAs’ root uptake in food chain contamination. This study showed that the roots of maize plant and cucumber are capable of absorbing AAs from nutrient solution, consequently producing strong peaks on ultraviolet HPLC chromatograms of plant extracts. This uptake resulted in even higher concentrations of AAs in the roots compared to the nutrient solutions. To further validate the measurement of AA content in the root material, we also measured their concentrations in nutrient solutions before and after the plant treatment. Decreased concentrations of both AAI and AAII were found in nutrient solutions after plant growth. During this short-term experiment, there were much lower concentrations of AAs in the leaves than in the roots. The question is whether these plants are capable of transferring significant amounts of AAs from the roots into edible parts of the plant during prolonged experiments. 相似文献
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Drăghia Lavinia Paula Lukinich-Gruia Alexandra Teodora Oprean Camelia Pavlović Nikola M. Păunescu Virgil Tatu Călin Adrian 《Environmental geochemistry and health》2021,43(10):4163-4178
Environmental Geochemistry and Health - Aristolochic acid I (AAI) is a potent nephrotoxic and carcinogenic compound produced by plants of the Aristolochiaceae family and thoroughly investigated as... 相似文献
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Thomas Elmqvist José Siri Erik Andersson Pippin Anderson Xuemei Bai Pranab Kishore Das Tatu Gatere Andrew Gonzalez Julie Goodness Steven N. Handel Ellika Hermansson Török Jessica Kavonic Jakub Kronenberg Elisabet Lindgren David Maddox Raymond Maher Cheikh Mbow Timon McPhearson Joe Mulligan Guy Nordenson Meggan Spires Ulrika Stenkula Kazuhiko Takeuchi Coleen Vogel 《Sustainability Science》2018,13(6):1549-1564
Cities are currently experiencing serious, multifaceted impacts from global environmental change, especially climate change, and the degree to which they will need to cope with and adapt to such challenges will continue to increase. A complex systems approach inspired by evolutionary theory can inform strategies for policies and interventions to deal with growing urban vulnerabilities. Such an approach would guide the design of new (and redesign of existing) urban structures, while promoting innovative integration of grey, green and blue infrastructure in service of environmental and health objectives. Moreover, it would contribute to more flexible, effective policies for urban management and the use of urban space. Four decades ago, in a seminal paper in Science, the French evolutionary biologist and philosopher Francois Jacob noted that evolution differs significantly in its characteristic modes of action from processes that are designed and engineered de novo (Jacob in Science 196(4295):1161–1166, 1977). He labeled the evolutionary process “tinkering”, recognizing its foundation in the modification and molding of existing traits and forms, with occasional dramatic shifts in function in the context of changing conditions. This contrasts greatly with conventional engineering and design approaches that apply tailor-made materials and tools to achieve well-defined functions that are specified a priori. We here propose that urban tinkering is the application of evolutionary thinking to urban design, engineering, ecological restoration, management and governance. We define urban tinkering as:
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A mode of operation, encompassing policy, planning and management processes, that seeks to transform the use of existing and design of new urban systems in ways that diversify their functions, anticipate new uses and enhance adaptability, to better meet the social, economic and ecological needs of cities under conditions of deep uncertainty about the future.This approach has the potential to substantially complement and augment conventional urban development, replacing predictability, linearity and monofunctional design with anticipation of uncertainty and non-linearity and design for multiple, potentially shifting functions. Urban tinkering can function by promoting a diversity of small-scale urban experiments that, in aggregate, lead to large-scale often playful innovative solutions to the problems of sustainable development. Moreover, the tinkering approach is naturally suited to exploring multi-functional uses and approaches (e.g., bricolage) for new and existing urban structures and policies through collaborative engagement and analysis. It is thus well worth exploring as a means of delivering co-benefits for environment and human health and wellbeing. Indeed, urban tinkering has close ties to systems approaches, which often are recognized as critical to sustainable development. We believe this concept can help forge much-closer, much-needed ties among engineers, architects, evolutionary ecologists, health specialists, and numerous other urban stakeholders in developing innovative, widely beneficial solutions for society and contribute to successful implementation of SDG11 and the New Urban Agenda.
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Bunnell JE Tatu CA Bushon RN Stoeckel DM Brady AM Beck M Lerch HE McGee B Hanson BC Shi R Orem WH 《Environmental geochemistry and health》2006,28(6):577-587
In May and September, 2002, 14 private residential drinking water wells, one dewatering well at a lignite mine, eight surface
water sites, and lignite from an active coal mine were sampled in five Parishes of northwestern Louisiana, USA. Using a geographic
information system (GIS), wells were selected that were likely to draw water that had been in contact with lignite; control
wells were located in areas devoid of lignite deposits. Well water samples were analyzed for pH, conductivity, organic compounds,
and nutrient and anion concentrations. All samples were further tested for presence of fungi (cultures maintained for up to
28 days and colonies counted and identified microscopically) and for metal and trace element concentration by inductively-coupled
plasma mass spectrometry and atomic emission spectrometry. Surface water samples were tested for dissolved oxygen and presence
of pathogenic leptospiral bacteria. The Spearman correlation method was used to assess the association between the endpoints
for these field/laboratory analyses and incidence of cancer of the renal pelvis (RPC) based on data obtained from the Louisiana
Tumor Registry for the five Parishes included in the study. Significant associations were revealed between the cancer rate
and the presence in drinking water of organic compounds, the fungi Zygomycetes, the nutrients PO4 and NH3, and 13 chemical elements. Presence of human pathogenic leptospires was detected in four out of eight (50%) of the surface
water sites sampled. The present study of a stable rural population examined possible linkages between aquifers containing
chemically reactive lignite deposits, hydrologic conditions favorable to the␣leaching and transport of toxic organic compounds
from the lignite into the groundwater, possible microbial contamination, and RPC risk. 相似文献
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Tatu Anttila Veli-Matti Kerminen Markku Kulmala 《Atmospheric environment (Oxford, England : 1994)》2002,36(39-40)
In this theoretical investigation, we elucidated several factors governing the ability of organic, water-soluble vapours to participate into either the secondary organic aerosol formation or particle condensational growth in the atmosphere. The corresponding requirements for physico-chemical properties of the vapour were estimated. These estimates were also compared with the properties of several difunctional carboxylic acids identified in the atmosphere. Our analysis indicates that while many of the considered compounds are expected to contribute to the total particle mass in the atmosphere, their role in particle condensational growth process remains uncertain. This uncertainty emerges from the fact that the saturation ratio of an organic vapour does not alone determine its ability to act as a “nonvolatile” compound. Instead, the hygroscopic and chemical properties of the vapour, as well as the particle pH and size, have also to be taken into account. 相似文献
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Moldovan Z Schmutzer G Tusa F Calin R Alder AC 《Journal of environmental monitoring : JEM》2007,9(9):986-993
The mass flows of selected pharmaceuticals and personal care products (PPCPs) were studied in the aqueous compartment of the river Somes in Romania. PPCPs were measured in wastewater treatment effluents and in the receiving river water. The analytical method for the determination of PPCPs in river water was based on solid phase extraction and GC-ITMS. Carbamazepine, pentoxyfylline, ibuprofen, diazepam, galaxolide, tonalide and triclosan were determined in wastewater effluents with individual concentrations ranging from 15 to 774 ng L(-1). Caffeine was measured at concentrations up to 42 560 ng L(-1). Due to the high contamination of WWTP effluents, the receiving river was also polluted. The most abundant PPCPs measured in the Somes were caffeine, galaxolide, carbamazepine and triclosan. They were present at all the 15 sampling sites along the Somes, the concentrations ranging from 10 to 400 ng L(-1). The concentrations in the effluents of the different wastewater treatment plants (WWTPs) varied considerably and the differences are due to different elimination efficiencies of the studied PPCPs during sewage treatment. Only one of 5 WWTPs studied, the WWTP in Cluj-Napoca, was working properly, and therefore technical measures have to be taken for upgrading the WWTPs and reducing the environmental load of micropollutants. This study is the first overview of PPCPs along on Romanian part of river Somes. 相似文献