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Elena A. Zakharova Paul V. Kosterin Vitaly V. Brudnik Alexander A. Shcherbakov Alexander A. Ponomaryov Lubov F. Shcherbakova Vladimir G. Mandich Eugenii E. Fedorov Vladimir V. Ignatov 《Environmental science and pollution research international》2000,7(4):191-194
A plant-based bioremediation (phytoremediation) strategy has been developed and shown to be effective for the clean-up of
soil contaminated by the breakdown products of the chemical warfare agent (CWA), yperite. The method involves exploiting the
plant growth hormone, indole-3-acetic acid (IAA), to intensify the phytoremediation. For determination of the yperite breakdown
products, gas chromatography is used.
Soil and plant samples were analysed with a gas chromatograph fitted with an atomic emission detector. The method of standard-free
determination was employed to identify sulphur-containing substances (SCSs). A series of soil tests was conducted, which showed
that the level of SCSs decreased 4, 8, and more than 20-fold compared with that found in contaminated soil. This decrease
was dependent upon the IAA concentrations used for plant treatment. The treated plants accumulated 2.7 to 2.9-fold larger
amounts of the SCSs than did the untreated plants. Owing to its simplicity, environmental safety and inexpensiveness, the
method can be recommended for the restoration of soil fertility in areas of storage and destruction of blister CWAs. 相似文献
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Elina Leonova Karlis Shvirksts Mara Grube Lubov Ignatovich Calvin Yu-Chian Chen Tatjana Sjakste 《毒物与环境化学》2017,99(4):601-612
Ftorafur is an antimetabolite antitumour drug successfully used for treatment of various tumours. It is generally accepted that ftorafur is converted to 5-fluoruracil. However, some data indicate direct interactions of the compound with DNA. To test this hypothesis we have performed spectrophotometric study of DNA interactions of ftorafur and some of its elementoorganic derivatives with DNA. UV-VIS spectra of the tested compounds were recorded in absence and presence of increasing amounts of DNA. DNA caused a hypochromic effect in spectra of ftorafur, similar, but weaker effect was observed in 5-fluoruracil spectra. Trimethylgermyl derivative of ftorafur manifested a higher DNA-binding capacity compared to ftorafur. To reveal possible mechanism of interaction between the tested nucleosides and DNA ethidium bromide extrusion experiments were performed. It was shown that the compounds did not compete with EBr for intercalation. Fourier transformation infrared spectroscopy analyses revealed decrease in intensity of several bands in spectra of ftorafur, its trimethylgermyl derivative and fluorouracil in presence of DNA indicating again interactions between the compounds and DNA. Docking experiments reveal interactions of the tested nucleosides with the DNA minor groove. Thus ftorafur is capable to interact directly with DNA; further modifications of the molecule enhance this capacity. 相似文献
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