Is using nanosilver mattresses/pillows safe? A review of potential health implications of silver nanoparticles on human health

Human exposure to engineered nanoparticles has become inevitable in today’s extensive commercial use and large-scale production of engineered nanoparticles. Even though several studies have characterised the exposure to nanomaterials during wakeful state (related to occupational exposures and exposures from commercially available particles), very few studies on human exposure during sleep exist. As the study of exposure to all possible nanomaterials during sleep is extensive, this study focuses on exposure to specifically silver nanoparticles which are present in beddings and mattresses. The reasoning behind the use of silver nanoparticles in bedding and related materials, possible routes of entry to various population groups in several sleep positions, exposure characterisation and toxicity potential of such silver nanoparticles are reviewed in this study. The toxicity potential of silver nanoparticles in vivo tests with relation to mammals and in vitro tests on human cells has been tabulated to understand the risks associated during oral, dermal and inhalation exposure to silver nanoparticles. The exposure to humans with regard to dermal absorption and oral intake has been summarised. Although potential inhalation exposure to silver nanoparticles is increasing, only a few studies address the possible toxic effect of inhaled silver particles. Determination of exposure to silver nanoparticles in beddings is a topic that has been less researched, and this review aims to provide background information for future research and help establish a comprehensive risk assessment during sleep in the times of increasing usage of nanoparticles in our daily activities. Despite the current limitations of our understanding, risk assessments must utilise the available data and apply extrapolation procedures in the face of uncertainty, in order to address the needs of regulatory programs. This would enable safe use of the antimicrobial properties of silver nanoparticles without negatively impacting human health. Until then, it would be better to adopt a conservative approach on the usage of silver nanoparticles in daily used commercial items.

     

Bioaccumulation and depuration of chromium in the selected organs and whole body tissues of freshwater fish Cirrhinus mrigala individually and in binary solutions with nickel

Contamination of aquatic ecosystems with heavy metals has been receiving increased worldwide attention due to their harmful e ects on human health and other organisms in the environment. Most of the studies dealing with toxic e ects of metals deal with single metal species, while the aquatic organisms are typically exposed to mixtures of metals. Hence, in order to provide data supporting the usefulness of freshwater fish as indicators of heavy metal pollution, it has been proposed in the present study to investigate the bioaccumulation and depuration of chromium in the selected organs of freshwater fingerlings Cirrhinus mrigala, individually and in binary solutions with nickel. The results show that the kidney is a target organ for chromium accumulation, which implies that it is also the “critical” organ for toxic symptoms. The results further show that accumulation of nickel in all the tissues of C. mrigala is higher than that of chromium. In addition, the metal accumulations of the binary mixtures of chromium and nickel are substantially higher than those of the individual metals, indicating synergistic interactions between the two metals. Theoretically the simplest explanation for an additive joint action of toxicants in a mixture is that they act in a qualitatively similar way. The observed data suggest that C. mrigala could be suitable monitoring organisms to study the bioavailability of water-bound metals in freshwater habitats.     

Bioaccumulation of lead and the influence of chelating agents in Catla catla fingerlings

Lead is a widespread element and one of the persistent and cumulative pollutants of the environment. The present study deals with the bioaccumulation of lead and the influence of chelating agents, meso 2,3-dimercaptosuccinic acid (DMSA), D-Penicillamine and CaNa₂EDTA in reducing the concentration of lead on the selected organs of Catla catla fingerlings for both acute and chronic exposures by using ICP-AES. It is inferred from the present findings that there was a correlation between environmental conditions and the heavy metal contents of the fish. The highest concentration of lead is found in kidney tissues and the lowest in muscle tissues. The accumulation pattern of lead in the selected organs of Catla catla is: kidney > liver > gill > brain > muscle. Also, it has been found that the treatment of chelating agents, DMSA, D-Penicillamine and CaNa₂EDTA reduces the concentration of lead significantly for both acute and chronic exposures. The results also show that DMSA is the most effective chelator of lead in reducing the body burden of C. catla fingerlings. The observed data further indicate that C. catla could be suitable for monitoring organisms to study the bioavailability of water-bound metals in freshwater habitats.     

Effect of acute concentration of zinc on the biochemical contents of brain of Labeo rohita: an FT-IR study

Heavy metal discharges to aquatic environment are of great concern due to their toxicity and accumulative behavior. Zinc is an essential trace element required for different physiological functions and plays important role in cellular metabolism. However, it becomes toxic when elevated concentrations are introduced into the environment. The aim of this work is to analyze zinc induced biochemical changes in the brain tissues of Labeo rohita fingerlings using Fourier Transformation Infrared Spectroscopy. Several important features have been observed in the zinc intoxicated brain tissues, namely, altered membrane lipid, altered protein profile and decreased glycogen content, indicating an alteration in the lipid and protein profiles leading to modification in membrane composition. Further, it is observed that the acute exposure to zinc causes some alteration in protein profile with a decrease in α-helix and an increase in random coil structures.     

Climate change perceptions and adaptations of smallholder farmers in Eastern Kenya

Several studies have indicated the importance of understanding farmers’ perceptions of risks associated with climate change, the adaptation strategies they employ and factors that affect adaptive capacity. This study aimed to understand smallholder farmers’ perceptions of climate change, adaptation strategies and adaptive capacity in the semiarid Matungulu Sub-County, Eastern Kenya. A participatory approach, using three climate roundtables, was conducted to enhance community participation and understanding of climate change issues. The study showed that farmers’ perceptions concerning climate change are influenced by past experiences of weather extremes that have affected production levels and farm incomes. The farmers have made strategic responses to manage risks posed by climate change. However, they face several challenges in adaptation such as inadequate technical knowledge, low financial resources and inadequate land size. Further, the study showed that climate roundtables is a successful participatory approach that can give effective insights for smallholder farmers to understand agricultural vulnerability, climate change and their adaptation strategies.     

Participatory Model Calibration for Improving Resource Management Systems: Case Study of Rainwater Harvesting in an Indian Village

While planning resource management systems in rural areas, it is important to consider criteria that are specific to the local social conditions. Such criteria might change from one region to another and are hence best identified using a participatory approach. In this work, we propose a participatory framework to identify such criteria and derive their weights. These identified criteria and their weights are used as parameters to develop a quantitative model for evaluating efficiency of each system. Such a model can serve as a support tool for stakeholders to simulate and analyze “what‐if” scenarios, evaluate alternatives, and select one which best satisfies their requirements. We use existing systems to test the model by comparing efficiencies evaluated by the model to efficiencies perceived by the stakeholders. The model is calibrated by repeating the process until statistically significant correlation is achieved between evaluated and perceived efficiencies. The novelty of the proposed framework lies in treating efficiencies perceived by the stakeholders as the ground truth since they know these systems well and are their ultimate users. The framework is successfully demonstrated using case study of rainwater harvesting (RWH) systems in an Indian village. The resulting calibrated model can be used to plan new RWH systems in this region and similar regions elsewhere. The framework can be used to plan other resource management systems in various regions.