Bright photophase accelerates re-entrainment after experimental jetlag in Drosophila

The efficacy of bright photophase (BP) in accelerating the re-entrainment of Drosophila biarmipes rhythm following 8?h phase advance and delay of light–dark (LD) cycle was examined by subjecting the flies to 24?h LD cycles with dim photophase (DP) at 30?lx and BP at 300?lx. Re-entrainment was analysed by using the activity onset, activity offset and the duration of activity. Following LD advance or delay, the BP flies re-entrained faster than the DP flies which was attributed to the enhanced zeitgeber strength of BP. Nevertheless, the re-entrainment was a protracted process even in the BP flies since the activity offsets underwent more transients than the activity onsets. Thus, this study demonstrates that the BP accelerates the re-entrainment in D. biarmipes. It, however, also reveals that the re-entrainment is a prolonged process when the activity onset and offset are regarded as the rhythm markers.     

Aerogels and metal–organic frameworks for environmental remediation and energy production

Environmental pollution and climate change are requiring new methods to clean pollutants and produce sustainable energy. Aerogels and metal organic frameworks are emerging as advanced porous materials with higher functionality, high surface area, high porosity and flexible chemistry. Aerogels are dried gels prepared using the sol–gel procedure, whereas metal organic frameworks are networks of organic ligands and metal ions connected by coordination bonds. Applications of aerogels include the removal of heavy metals, CO₂ capture and reduction, photodegradation of pollutants, air cleanup and water splitting. This article reviews the synthesis and types of aerogels and metal organic frameworks, and the application to pollutant removal, energy production including hydrogen, methane reforming, CO₂ conversion and NOx removal.     

Nanosystems for drug delivery of coenzyme Q10

Coenzyme Q10 is an antioxidant present in the human body. Coenzyme Q10 has an essential role in various biochemical reactions. The deficiency of coenzyme Q10 in the body leads to disorders including neurological degeneration, ageing and cancer. Clinical trials have tested coenzyme Q10 as a drug or a dietary supplement. However, the major pharmaceutical issue of coenzyme Q10 delivery is its high molecular weight and poor water solubility. This limitation leads to its poor oral bioavailability. Several methods have been designed to overcome the poor water solubility of coenzyme Q10, such as size reduction and ionization. This article presents nanotechnology-based drug delivery systems for coenzyme Q10 with special emphasis on pharmacokinetic perspectives and clinical relevance. Systems include nanoparticles, solid dispersions, liposomes, nanoemulsions, self-emulsifying drug delivery systems, nanostructured lipid carriers, cyclodextrins and nanocapsules.     

Bioremediation of industrial waste through mushroom cultivation

Handmade paper and cardboard industries are involved in processing of cellulosic and ligno-cellulosic substances for making paper by hand or simple machinery. In the present study solid sludge and effluent of both cardboard and handmade paper industries was collected for developing a mushroom cultivation technique to achieve zero waste discharges. Findings of present research work reveals that when 50% paper industries waste is used by mixing with 50% (w/w) wheat straw, significant increase (96.38%) in biological efficiency over control of wheat straw was observed. Further, cultivated basidiocarps showed normal morphology of stipe and pileus. Cross section of lamellae did not show any abnormality in the attachment of basidiospores, hymenal trama and basidium. No toxicity was found when fruiting bodies were tested chemically.     

Identification of a sensitive index during fish bioassay of an azo dye methyl red (untreated and treated)

Acute and chronic toxicity of methyl red (untreated) was examined on a freshwater fish Poecilia reticulata, using indices viz; mortality, reduction in RBC counts and their morphological abnormality (poikilocytosis and anisocytosis). Similar studies (acute toxicity) were also made in physicochemically and biologically treated methyl red. Data comparison of these four indices revealed poikilocytosis as the most sensitive index, since it measured higher toxicity of methyl red when fish mortality was either minimum at its low concentration (5 ppm) during both acute and chronic toxicity or even nil in the biologically treated 100 ppm methyl red, during acute toxicity. Mortality was next to poikilocytosis though it ranked 1st at higher concentration of methyl red during acute toxicity. The reduction in RBC counts however, was found to be the most sensitive parameter only in case of prolonged exposure (4 weeks) to 5 ppm methyl red. Amongst the four indices used for quantifying toxicity; anisocytosis was found to be the least expressive. Based on these findings we recommend quantification of data on fish mortality and poikilocytosis during acute toxicity whereas reduction in RBC counts and poikilocytosis during chronic exposure to methyl red.     

Assessment of environmental footprint using geospatial approach to ascertain the Sustainable Development Goal 2030s of India

Utilization of natural resources has multiplied globally, resulting in serious environmental deterioration and impeding the achievement of the Sustainable Development Goals (SDGs). For the harmonious development of human nourishment and the balance of nature, it is vital to evaluate environmental segments' resource usage, transformation, and residue, referred to as ‘footprint,’ in order to highlight carrying capacity and sustainability. This analysis highlights the Environmental Footprint (EF) of India per state from 2010 to 2020 in terms of hectares per capita. This study evaluates India's biological, hydrological, energy, ecological, and pollution footprints, carrying capacity, environmental pressure, and environmental deficit using 17 distinct parameters categorized under the themes of biological resource, hydrological resource, energy resource, and pollution concentration. We proposed a reoriented methodology and EF concepts that determine India's footprint, carrying capacity, nature of sustainability, environmental pressure index, and its consequential links to the 2030 SDGs. As a result, the biological resources contributed to ~50% of the environmental footprint, while hydrological, energy, and pollutants made up the remaining. Between 2010 and 2020, Delhi, Uttar Pradesh, Bihar, and West Bengal had the highest EF, while Jammu and Kashmir and the north-eastern provinces had the lowest. During the research period, the ecological deficit in India has increased overall. India impedes the 2030 SDGs; therefore, the study provides a picture of resource consumption, waste generation, economic growth, and societal changes, enabling academics and policymakers to redefine or document policy for a more sustainable future.     

A comparative study on the toxic effects of textile dye wastewaters (untreated and treated) on mortality and RBC of a freshwater fish Gambusia affinis (Baird and Gerard)

Comparative toxicological studies of textile dye wastewater (untreated and treated) on a freshwater fish, Gambusia affinis, revealed a marked reduction in mortality and cytotoxic effects on RBCs, measured as reduction in their counts and percent changes in their shape (poikilocytosis) and variation in their size (anisocytosis)}, after subjecting them to both physicochemical and biological treatments. On comparing the data of mortality and the cytotoxic effects on RBCs, we found poikilocytosis is a better indicator for toxicity measurement of both untreated as well as treated wastewater, especially at their lowest concentrations where percent mortality was found to be either nil or lowerer than the percentage of poikilocytic RBCs. Although percent reduction in RBC counts and changes in their size (anisocytosis) indicated toxic effects of wastewaters, but EC5o values for RBC counts were usually higher than those for poikilocytosis and mortality, and non-calculable for anisocytosis suggesting their lesser sensitivity to pollutants. In view of these findings, we recommend monitoring of toxic effects of wastewaters during fish bioassay on both mortality and variation in RBC shape.     

Challenges of small protected areas in urban cities: a case study of Okhla Bird Sanctuary,India

Protected areas have been earmarked throughout the world for the purpose of conserving the biodiversity. The protected areas are facing serious threats due to rapid urban growth, especially in the developing countries like India. The current threats and impacts of urbanization on the Okhla Bird Sanctuary (Delhi, India) have been presented in this paper as a case in point. Uncontrolled urbanization and the lack of policy implementation have been identified as one of the major contributors to incessant biodiversity loss in India and other countries. In addition, a possible management framework for a smaller protected area in an urban setting is presented in brief.     

Dietary selenium fortification: a potential solution to chronic arsenic toxicity

Selenium (Se), an important micronutrient and antioxidant, also acts as an antagonist of arsenic (As). Se supplementation of diet was investigated in mitigating chronic As toxicity in mammals. Experiments were conducted to determine whether Se supplementation in As-exposed rats might (i) decrease As-induced lipid peroxidation in liver, (ii) increase blood antioxidant status, and (iii) reverse suppression of the secondary antibody response. Male Wistar rats were exposed to As (40 and 80?ppm) in drinking water and received challenge diets with three different levels of Se (deficient: <0.01?ppm, adequate: 0.15 ppm, and fortified: 0.6?ppm) for 16 weeks. Clinical variables including behavior, body weight, and food and water consumption were recorded weekly, and blood sample was collected monthly. Antioxidant status was assessed through glutathione sulfhydryl (GSH) levels in whole blood. Lipid peroxidation in the liver was evaluated using the malondialdehyde (MDA) assay. The antibody response was measured using keyhole limpet hemocyanin as an immunogen. Se deficiency significantly increased hepatic lipid peroxidation and suppressed antibody production relative to the Se-adequate and -fortified groups, confirming that Se deficiency exacerbates the damage produced by As exposure. Se fortification markedly elevated the blood GSH level in both As-exposed groups, indicating protective effects. At adequate Se levels, rats showed signs of counteracting As-mediated toxicity. However, Se fortification produced more pronounced benefits against As-induced toxicity, a pattern that was particularly notable in the 40?ppm As group.