Anticancer mechanisms of phytochemical compounds: focusing on epigenetic targets

Environmental Science and Pollution Research - It has recently been proven that epigenetic dysregulation is importantly involved in cell transformation and therefore induces cancerous diseases. The...     

Physiopathology and effectiveness of therapeutic vaccines against human papillomavirus

Environmental Science and Pollution Research - Human papillomavirus (HPV) is a well-known sexually transmitted disorder globally. Human papillomavirus (HPV) is the 3rd most common cancer that...     

Valorization of regenerated LDPE by blending with EPDM in the presence of peroxide

The present work aims to the valorization of regenerated low density polyethylene (LDPE) by blending with small quantities of ethylene-propylene-diene monomer (EPDM). Three types of regenerated LDPE (rLDPE) from different waste sources (greenhouses, milk pouches,...) were characterized in terms of physico-chemical (density, melt flow index, water absorption, melting temperature and structure by Fourier transform infrared (FTIR) spectroscopy) and mechanical properties (tensile properties and hardness). The optimization of the peroxide content required for the crosslinking of the LDPE/EPDM blends was due by measuring torque and tensile strength. Once the peroxide content was optimized, different blends were obtained by varying the EPDM content. Then they were characterized physically (density, water absorption) and mechanically (tensile properties and hardness). Finally, the blends behavior under the conjugated effect of heat and water was determined at 70 °C for 7 days. The obtained results showed that this kind of blending has contributed in improving the performance of regenerated LDPE.     

Climate change and modeling of an unconfined aquifer: the Triffa plain,Morocco

The Triffa plain covering about 307 km² is located in the semiarid region of northeastern Morocco. The cover consists of Quaternary and Mio-Pliocene formations, including alluvial material, silt, sandstone, limestone, clay, and marl, underlain by a sequence of Jurassic carbonates and clastics. Two principal aquifers occur in this region: (1) An unconfined aquifer hosted by the Quaternary formations, which opens up on the coastal plain of Saïdia, giving rise to the Aïn Chebbak and Aïn Zebda springs; and (2) a confined aquifer hosted by the underlying Liassic (Jurassic) formations, composed of limestone and dolostone. In this paper, we present a conceptual hydrogeological model for the Triffa aquifer, which opens laterally into the Saïdia aquifer, based on borehole data, bedrock geology, hydrodynamic parameters, piezometric maps, and time series groundwater level and precipitation data, obtained from several meteorological stations and pumping wells. These comprehensive data were incorporated in the Geographic Information System platform and processed using groundwater modeling software, with the development of the numerical model and its limitations discussed in detail in the present work. Subsequently, we evaluated the impact of climate change on the Triffa aquifer, assuming three different climate scenarios developed by the Intergovernmental Panel on Climate Change. These were the B1—low, A1B—mean, and A1F1—extreme scenarios, which we modeled by simulating a decrease in the recharge in all of the study area up to year 2099 that would correspond to 9, 19, and 47%, respectively. The calibration of the model in steady and transient states produced a good agreement between the observed and simulated heads. The simulation of the impact of climate change on groundwater by a decrease in the recharge highlights the groundwater drawdown occurring in this region. This work can significantly help the authorities in the sustainable management and exploitation of local groundwater.     

Anticancer properties of medicinal plants and their bioactive compounds against breast cancer: a review on recent investigations

Environmental Science and Pollution Research - Breast cancer (BC) is one of the most common and recurring diseases and the second leading cause of death in women. Despite prevention, diagnostics,...