Prenatal diagnosis of Apert syndrome: report of two cases

Two de novo cases with Apert Syndrome detected prenatally are presented herein. In the first, fetal ultrasound findings of syndactyly of the hands, craniosynostosis and proptosis resulted in a prenatal diagnosis in the nineteenth week of gestation. This is the earliest prenatal diagnosis of this syndrome in a not-at-risk case. Following counseling, this pregnancy was terminated and subsequent pathological examination and DNA analysis confirmed the diagnosis of Apert Syndrome and coarctation of the aorta. In the second case, fetal ultrasound at 21 weeks' gestation revealed a hypoplastic left heart and clover-leaf skull. Following counseling, this pregnancy was also terminated. Further examination of the fetus and DNA analysis led to a diagnosis of Apert Syndrome. These cases emphasize the need to complete a thorough fetal ultrasound in cases with potentially lethal cardiac abnormality and the importance of incorporating a fetal pathologist, as well as a medical geneticist, in the investigations performed after delivery or pregnancy termination when a fetal abnormality is detected on ultrasound. Copyright © 2003 John Wiley & Sons, Ltd.     

Biomonitoring of heavy metals in the feathers of House crow (Corvus splendens) from some metropolitans of Asia and Africa

Environmental Science and Pollution Research - Urban-dwelling birds can be useful biomonitors to assess the impact of the urbanisation on both public and wildlife health. Widely distributed urban...     

Refining logistic regression models for wildlife habitat suitability modeling—A case study with muntjak and goral in the Central Himalayas, India

High quality habitat suitability maps are indispensable for the management and planning of wildlife reserves. This is particularly important for megadiverse developing countries where shortages in skilled manpower and funding may preclude the use of mathematically complex modeling techniques and resource-intensive field surveys. In this study, we propose a simulation based k-fold partitioning and re-substitution approach to refine and update logistic regression models that are widely used for habitat suitability assessment and modeling. We test the modeling strategy using data from a rapid field survey conducted for habitat suitability assessment for muntjak (Muntiacus muntjak) and goral (Naemorrhaedus goral) in the central Himalayas, India. Results obtained from simulations match expectations in terms of model behavior and in terms of published habitat associations of the investigated species. Qualitative comparisons with predictions from the GARP, MaxEnt and Bioclimatic Envelopes modeling systems also show broad agreement with predictions obtained from the proposed technique. The proposed technique is suggested as a rapid-assessment precursor to detailed habitat studies such as patch occupancy modeling in situations where funds or trained manpower are not available.     

Influencing resilience: the role of policy entrepreneurs in mainstreaming climate adaptation

One way to make development pathways more resilient in the face of a changing climate has been through mainstreaming adaptation into government policies, planning and sectoral decision‐making. To date, many of the transferable lessons have taken the form of technical approaches such as risk assessments and toolkits. This article instead draws on evidence from South Asia to emphasise some of the more tacit and informal approaches used to influence adaptation policy. Despite their apparent significance in policy processes, such tactics are often neither planned for nor well reported in resilience‐building projects and programme documents. Using evidence to populate a typology of influencing strategies, this article looks particularly at the role of policy entrepreneurs who navigate the political complexity of both formal and informal governance systems to promote successful adaptation mainstreaming. It concludes with recommendations for adaptation and resilience programming that can more effectively harness the breadth of influencing strategies.     

Worldwide contamination of water by fluoride

Fluoride contamination in water is a major problem across the globe, with health hazards such as dental and skeletal fluorosis. Most earlier studies are confined to local or regional scales. As the problem has serious socioeconomic implications, there is a need for a global perspective. Thus, here we review worldwide research for nearly a century on fluoride contamination in water. We investigated the distribution of fluoride contamination in water, its sources, mobilization and association. The major findings are: (1) Anomalous fluoride concentration in groundwater is mainly confined to arid and semiarid regions of Asia and North Africa. (2) The geogenic sources of fluoride in water are mainly fluorine-bearing minerals in rocks and sediments, whereas anthropogenic sources of fluoride in water are mainly pesticides and industrial waste. (3) Fluoride mobilization from geogenic sources is mainly controlled by alkalinity and temperature. (4) Fluoride occurrence in water is associated with ions such as sodium, arsenic chloride and bicarbonate. There are few associations of fluoride in water with calcium and magnesium.     

Variation in vegetation cover and livestock mobility needs in Sahelian West Africa

A new approach was developed to evaluate the implications of the spatiotemporal variability of green vegetation for the dispersion of livestock that is required to access quality forage in semi-arid Africa. Maximum NDVI (Normalized Difference Vegetation Index) at 1 km² resolution was determined for concentric rings (0–31 km radii) around 227 individual sample locations within the study area for 14 dates (between 1 April to 1 November) annually over the 2000–2010 period. A sigmoidal curve was fitted to points within the maximum NDVI × distance radii space to determine the asymptote distance (AD) – the radius at which further dispersion from the sample location does not lead to significant gains in access to green forage. AD was found to: increase with latitude (or increasing aridity); decline as the rainy season proceeds; and show no trend over the 2000–2010 period. These results introduce much-needed empirical data to current debates surrounding the scales of governance to support livestock mobility.     

Developing a standard for psychosocial risk management: PAS 1010

The nature of work has changed dramatically due to globalisation, migration, technological advances and the emergence of the knowledge-based economy. These changes have been accompanied by the increased prevalence of new and emerging types of risk to workers’ health and safety, such as psychosocial risks. This paper reviews the key regulatory and voluntary standards on occupational health and safety of relevance to the management of psychosocial risks in the workplace that are applicable to the European Union member states. The review indicates that regulatory standards set the minimum level of protection for workers and voluntary standards may further enable organisations to go beyond their legal obligations. However, the review also highlights that the terms ‘stress’ and ‘psychosocial risks’ are not mentioned explicitly in most pieces of legislation leading to lack of clarity on the terminology used. While voluntary standards seek to address this, very few provide specific guidance on the process of psychosocial risk management to enable organisations to manage psychosocial risks successfully. On the basis of the review, the case for the development of a voluntary standard for psychosocial risk management is presented. The paper further discusses the recent development of such a standard and its implications at the European level.     

Fluoride toxicity variably affects overall physiology and grain development in three contrasting rice genotypes,representing a potential biohazard

Environmental Science and Pollution Research - Ingestion of fluoride through consumption of contaminated food grains has been regarded to be hazardous for consumer health. The current study...