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Deng Yan-Ling Yang Pan Wang Yi-Xin Liu Chong Luo Qiong Shi Tian Zeng Jia-Yue Lu Ting-Ting Chen Pan-Pan Miao Yu Zhang Min Cui Fei-Peng Lu Wen-Qing Zeng Qiang 《Environmental science and pollution research international》2022,29(54):81749-81759
Environmental Science and Pollution Research - Previous studies have reported that exposure to phthalates and polycyclic aromatic hydrocarbons (PAHs) is individually associated with altered semen... 相似文献
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Qiang Zeng Pan-Pan Chen Pan Yang Chong Liu Yan-Ling Deng Qiong Luo Yu Miao Min Zhang Fei-Peng Cui Jia-Yue Zeng Tian Shi Ting-Ting Lu Da Chen Long-Qiang Wang Chun-Ping Liu Ming Jiang 《环境科学学报(英文版)》2022,120(10):30-40
Phenols have been shown to influence the cellular proliferation and function of thyroid in experimental models. However, few human studies have investigated the association between phenol exposure and thyroid cancer, and the underlying mechanisms are also poorly understood. We conducted a case-control study by age- and sex-matching 143 thyroid cancer and 224 controls to investigate the associations between phenol exposures and the risk of thyroid cancer, and further to explore the mediating role of oxidative stress. We found that elevated urinary triclosan (TCS), bisphenol A (BPA) and bisphenol S (BPS) levels were associated with increased risk of thyroid cancer (all P for trends < 0.05), and the adjusted odds ratios (ORs) comparing the extreme exposure groups were 3.52 (95% confidence interval (CI): 2.08, 5.95), 2.06 (95% CI: 1.06, 3.97) and 7.15 (95% CI: 3.12, 16.40), respectively. Positive associations were also observed between urinary TCS, BPA and BPS and three oxidative stress biomarkers measured by 8-hydroxy-2′-deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoPGF2α) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), as well as between urinary 8-isoPGF2α and HNE-MA and the risk of thyroid cancer. Mediation analysis showed that urinary 8-isoPGF2α mediated 28.95%, 47.06% and 31.08% of the associations between TCS, BPA and BPS exposures and the risk of thyroid cancer, respectively (all P < 0.05). Our results suggest that exposure to TCS, BPA and BPS may be associated with increased risk of thyroid cancer and lipid peroxidation may be an intermediate mechanism. Further studies are warranted to confirm the findings. 相似文献
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