A survey of diagnostic amniocenteses in Oxford from 1974–1981

A survey was conducted of the results of mid-trimester diagnostic amniocenteses in the Oxford Region from 1974 to 1981. The survey used data relating to all 4357 singleton pregnancies in which an amniocentesis was performed during this period. Follow-up information on outcome was obtained in respect of 4284 (98 per cent) pregnancies. A cell culture to determine karyotype and an alpha-fetoprotein determination was carried out in all cases. From 1974 to 1981 amniocenteses became increasingly common, rising from 2 to 32 per 1000 births. The most common indication for amniocentesis was a high risk of a chromosome abnormality–56 per cent of all amniocenteses. Within this group advanced maternal age was responsible for 89 per cent of the cases. The next most common indication was a high risk of a neural tube defect (37 per cent of all amniocenteses)–in 1974 a raised maternal serum alpha-fetoprotein level accounted for only 4 per cent of these; by 1981 this had risen to 67 per cent. There were seven false-positive and 132 true-positive diagnoses of neural tube defect; since 1981, with the introduction of amniotic fluid acetylocholinesterase determination as a secondary diagnostic test for neural tube defects, there have been no further false-positive diagnoses. In 1981 76 per cent of women aged 35 years or more did not have an amniocentesis. It is not known to what extent this was due to not offering women in this age group amniocentesis or to women not accepting such an offer.     

Effectiveness of biodiversity-conservation marketing

Conservation marketing holds potential as a means to engage audiences with biodiversity conservation and help to address the human dimensions of biodiversity loss. Empirical evaluations of conservation marketing indicatives are growing, so we reviewed the literature on this research to inform future directions in the field. We used a systematic search strategy to identify studies that evaluated the effects of conservation marketing interventions (techniques and campaigns) on psychosocial outcomes, categorized as cognitive, affective, or behavioral. Six academic databases (Business Source Complete, Communication & Mass Media Complete, Greenfile, Proquest, Scopus, and Web of Science Core Collections), 3 gray-literature databases (BASE, Zenodo, and Google Scholar), and 2 websites (Rare and WildAid) were searched. Articles were subjected to critical appraisal to assess their methodological quality, and data were extracted from each article and analyzed using narrative synthesis. Altogether 28 studies from 26 articles were included in the review. Twenty-five studies were conducted from 2014 through 2016. Methodological quality of most studies was weak (n = 16, 57%) (moderate quality n = 8, 29%; high quality n = 4, 14%). The proportion of studies that evaluated a conservation-marketing technique (e.g., variants of texts, images, or videos) versus a campaign (e.g., community-based campaigns targeting locally relevant issues, such as unsustainable palm oil agriculture, light pollution, or wood fuel fire use) was relatively balanced. Although many studies reported statistically significant results in the intended direction, the utility of findings was limited by persistent methodological limitations, such as a lack of a comparator group, use of non-validated assessment tools, and a focus on self-reported data and subjective outcomes. Conservation marketing is clearly a nascent field of scientific enquiry that warrants further, high-quality research investigations.     

A new economic instrument for financing accelerated landfill aftercare

The key aspects of landfill operation that remain unresolved are the extended timescale and uncertain funding of the post-closure period. This paper reviews the topic and proposes an economic instrument to resolve the unsustainable nature of the current situation. Unsustainability arises from the sluggish degradation of organic material and also the slow flushing of potential pollutants that is exacerbated by low-permeability capping. A landfill tax or aftercare provision rebate is proposed as an economic instrument to encourage operators to actively advance the stabilization of landfilled waste. The rebate could be accommodated within existing regulatory and tax regimes and would be paid for: (i) every tonne of nitrogen (or other agreed leachate marker) whose removal is advanced via the accelerated production and extraction of leachate; (ii) every tonne of non-commercially viable carbon removed via landfill gas collection and treatment. The rebates would be set at a level that would make it financially attractive to operators and would encourage measures such as leachate recirculation, in situ aeration, and enhanced flushing. Illustrative calculations suggest that a maximum rebate of up to ～€50/tonne MSW would provide an adequate incentive.     

Surface Air Pollutant Concentration Frequency Distributions: Implications for Urban Modeling

With the development of ambient air quality standards (AAQS), the need arises to describe the characteristics of regional surface air-pollutant concentration frequency distributions. In the evaluation of land use plans, numerous agencies will be concerned with evaluating the effectiveness of emission zoning and/or control actions. On a regional basis, one means of performing this assessment lies in determining the changes in the pollutant frequency distributions resulting from control actions.

This study presents new data concerning the surface air-pollutant concentration frequency distributions observed for area sources and continuous point sources, and compares these distributions with those of the pertinent meteorological variables describing the transport and diffusion of the pollutant. The observed surface air pollutant frequency distributions are compared to those corresponding to simple modeling concepts from either an urban area source or a continuous point source. For an urban source and a relatively inert pollutant like CO, we found that the observed frequency distribution for CO surface air concentration parallels the approximately log-normal frequency distribution of the reciprocal of the wind speed. We show that the constant relating these two well-correlated frequency distributions can be determined either experimentally or with a numerical simulation model of air pollution. The usefulness of numerical models in air pollution is discussed.     

Estimating resource utilization demands in implementing statewide screening,brief intervention,and referral to treatment for alcohol-impaired drivers

Objectives: The Alcohol Use Disorders Identification Test (AUDIT) is used to assess the level of alcohol use/misuse and to inform the intensity of intervention delivered within screening, brief intervention, and referral to treatment (SBIRT) programs. Policy initiatives are recommending delivery of SBIRT within health care settings to reduce alcohol misuse and prevent alcohol-impaired driving. Recent reports are considering extending delivery of SBIRT to criminal justice settings. One consideration in implementing SBIRT delivery is the question of resource utilization; the amount of effort required in delivering the 4 different intensities of intervention in SBIRT: Alcohol education, simple advice, brief counseling and continued monitoring, and brief counseling and referral to specialist (from least to most intense in terms of delivery time, the skill level of the provider, and personnel resources).

Methods: In order to inform expectations about intervention intensity, this article describes the AUDIT scores from 982 adults recently arrested for alcohol-impaired driving. The distribution of scores is extrapolated to state rates for individuals arrested for alcohol-impaired driving by intervention level.

Results: Though alcohol education was the most common intervention category, about one quarter of the sample scored in a range corresponding with the more intensive interventions using the brief counseling, continued monitoring for ongoing alcohol use, and/or referral to specialist for diagnostic evaluation and treatment.

Conclusions: This article provides local distribution of AUDIT scores and state estimates for the number of individuals scoring in each level of risk (AUDIT risk zone) and corresponding intervention type. Routine criminal justice practice is well positioned to deliver alcohol screening, education, simple advice, and continued alcohol monitoring, making delivery of SBIRT feasible for the majority of alcohol-impaired drivers. Challenges to implementing the full range of SBIRT services include resource demands of brief counseling, identifying the appropriate providers within a criminal justice context, and availability of community providers for referral to diagnostic and specialty care. Solutions may vary by state due to differences in population density and incidence rates of alcohol-impaired driving.     

Distribution of enzymes of glycolysis and gluconeogenesis in fish tissues

Gluconeogenesis in fishes has been demonstrated in whole animals and liver preparations. However, at present, the relative physiological importance of possible substrates such as lactate, pyruvate and amino-acids or the precise sites of gluconeogenesis are unclear. In mammals, gluconeogenesis takes place in the liver and kidney, and the same could occur in fishes although it has been proposed that fish red muscle is also capable of reconverting lactate (derived from white muscle) to glucose. In this present study, the activities of 3 key glycolytic (hexokinase, phosphofructokinase and pyruvate kinase) and 2 key gluconeogenic (fructose diphosphatase and phosphoenolpyruvate carboxykinase) enzymes were investigated in tissues of the rainbow trout Salmo gairdneri, the cod Gadus morhua, and the plaice Pleuronectes platessa in order to elucidate the relative glycolytic/gluconeogenic capacities of the individual fish tissues. The glycolytic enzymes were found in all tissues, the relative potential being skeletal muscle>heart, brain >kidney, gills>liver. The gluconeogenic enzymes were not present in all tissues, and were mainly concentrated in the liver and kidney. Hence the results indicate that the liver, and to a lesser degree, the kidney are the major sites of gluconeogenesis in fishes, and that the process is unlikely to occur in skeletal muscle.