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JAIME L. PETERS ALEX J. SUTTON DAVID R. JONES LESLEY RUSHTON KEITH R. ABRAMS 《Journal of environmental science and health. Part. B》2013,48(7):1245-1258
To maximize the findings of animal experiments to inform likely health effects in humans, a thorough review and evaluation of the animal evidence is required. Systematic reviews and, where appropriate, meta-analyses have great potential in facilitating such an evaluation, making efficient use of the animal evidence while minimizing possible sources of bias. The extent to which systematic review and meta-analysis methods have been applied to evaluate animal experiments to inform human health is unknown. Using systematic review methods, we examine the extent and quality of systematic reviews and meta-analyses of in vivo animal experiments carried out to inform human health. We identified 103 articles meeting the inclusion criteria: 57 reported a systematic review, 29 a systematic review and a meta-analysis, and 17 reported a meta-analysis only. The use of these methods to evaluate animal evidence has increased over time. Although the reporting of systematic reviews is of adequate quality, the reporting of meta-analyses is poor. The inadequate reporting of meta-analyses observed here leads to questions on whether the most appropriate methods were used to maximize the use of the animal evidence to inform policy or decision-making. We recommend that guidelines proposed here be used to help improve the reporting of systematic reviews and meta-analyses of animal experiments. Further consideration of the use and methodological quality and reporting of such studies is needed. 相似文献
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We sent out a targeted questionnaire to organizations and private individuals across the UK that have expressed an interest
in squirrel management and conservation. Respondents were asked to evaluate shooting, trapping, poisoning and immunocontraception
(IMC), according to their perceived efficacy, cost efficiency, and whether they were considered to be humane. The majority
of both professionals and enthusiasts indicated support for grey squirrel control to help conserve red squirrels and to reduce
economic damage to timber crops. Respondents\' comparative evaluations of current forms of control showed that trapping is
the most acceptable method. When IMC is compared with the other methods, it was considered to be more humane and acceptable.
In contrast, poisoning was seen as humane or acceptable by the fewest respondents. Furthermore, poisoning elicited the greatest
difference in opinion between the professional and enthusiast groups. This difference (34\%) may be interpreted partly as
concern over the type of death that results from poisoning and partly as due to the possibility of poisoning nontarget species.
Our findings indicate a need for more public information regarding secondary poisoning hazards to other species and their
predators. Interest and concern about squirrel control correlated with the overlap between contemporary areas of distribution
of the two species. It is these areas where consultation and education programs about control methods should be targeted.
This research indicates that there would be support for grey squirrel control using IMC from both lay and professional interest
groups. It demonstrates the existence of a sound basis for constructive dialog that can lead to the design and implementation
of acceptable and efficient control strategies. 相似文献
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MELINDA L. MOIR PETER A. VESK KARL E.C. BRENNAN DAVID A. KEITH LESLEY HUGHES MICHAEL A. McCARTHY 《Conservation biology》2010,24(3):682-690
Abstract: Coextinction is a poorly quantified phenomenon, but results of recent modeling suggest high losses to global biodiversity through the loss of dependent species when hosts go extinct. There are critical gaps in coextinction theory, and we outline these in a framework to direct future research toward more accurate estimates of coextinction rates. Specifically, the most critical priorities include acquisition of more accurate host data, including the threat status of host species; acquisition of data on the use of hosts by dependent species across a wide array of localities, habitats, and breadth of both hosts and dependents; development of models that incorporate correlates of nonrandom host and dependent extinctions, such as phylogeny and traits that increase extinction‐proneness; and determination of whether dependents are being lost before their hosts and adjusting models accordingly. Without synergistic development of better empirical data and more realistic models to estimate the number of cothreatened species and coextinction rates, the contribution of coextinction to global declines in biodiversity will remain unknown and unmanaged. 相似文献
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MELINDA L. MOIR PETER A. VESK KARL E. C. BRENNAN DAVID A. KEITH MICHAEL A. McCARTHY LESLEY HUGHES 《Conservation biology》2011,25(4):787-796
Abstract: Invertebrates with specific host species may have a high probability of extinction when their hosts have a high probability of extinction. Some of these invertebrates are more likely to go extinct than their hosts, and under some circumstances, specific actions to conserve the host may be detrimental to the invertebrate. A critical constraint to identifying such invertebrates is uncertainty about their level of host specificity. We used two host‐breadth models that explicitly incorporated uncertainty in the host specificity of an invertebrate species. We devised a decision protocol to identify actions that may increase the probability of persistence of a given dependent species. The protocol included estimates from the host‐breadth models and decision nodes to identify cothreatened species. We applied the models and protocol to data on 1055 insects (186 species) associated with 2 threatened (as designated by the Australian Government) plant species and 19 plant species that are not threatened to determine whether any insect herbivores have the potential to become extinct if the plant becomes extinct. According to the host‐breadth models, 18 species of insect had high host specificity to the threatened plant species. From these 18 insects, the decision protocol highlighted 6 species that had a high probability of extinction if their hosts were to become extinct (3% of all insects examined). The models and decision protocol have added objectivity and rigor to the process of deciding which dependent invertebrates require conservation action, particularly when dealing with largely unknown and speciose faunas. 相似文献
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