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Thays de Andrade Guedes Cristina Moreira-de-Sousa Hellen Maria Soares Lima Tatiane Caroline Grella Priscila Cintra Socolowski Carmem Silvia Fontanetti 《Journal of environmental science and health. Part. B》2020,55(8):687-693
AbstractThe objective of this research was to investigate the potential damage caused by the residual concentrations of the insecticides Regent® WS 800 and Curbix® SC 200, containing fipronil and ethiprole, respectively as active ingredients, on the liver of Oreochromis niloticus. The analyses of HSP70 shock protein labelling and cell death process by TUNEL method were performed in order to measure the effects of the exposure of cell repair system of fish to both insecticides. Statistical analyses showed no significant molecular damage to the hepatic tissue of animals. Nevertheless, variations in HSP70 and DNA fragmentation levels, endpoint of cell repair system response and cellular death, respectively, were observed in several groups. These results indicate that the cell repair machinery was efficient when in contact with residual concentrations of insecticides. However, the DNA fragmentation detected by the TUNEL method suggests that even in face of the cytoprotective action of the HSP70 protein, there are damages that become irreparable. To finish, it is worth mentioning that given the results obtained from residual concentrations, use in the field should be with caution. 相似文献
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Yadira Ansoar-Rodríguez Cintya A. Christofoletti Jorge E. Correia Raphael B. de Souza Cristina Moreira-de-Sousa Ana Claudia de Castro Marcato 《Journal of environmental science and health. Part. B》2016,51(12):881-887
Liver is very sensitive to environmental contaminants such as pesticides, it being the first target of toxicity of a substance. The objective of this study was to investigate the possible effects of the insecticide imidacloprid (IMI) on the liver of Oreochromis niloticus according concentrations used for growing sugarcane. A semi-quantitative analysis of histopathological alterations of IMI on liver was performed by light microscopy and cellular labeling of heat shock proteins (HSP70) by immunohistochemistry. The most common changes in liver at all concentrations of IMI were hydropic degeneration, pyknotic nuclei, and loss of cell limits. Steatosis and increased levels of HSP70 were detected in hepatocytes with the highest concentration of IMI. In conclusion, the tested concentrations of IMI induced histopathological changes in the liver of O. niloticus and active defence mechanisms to maintain the morphophysiological integrity of the liver. This insecticide has a toxicity potential for these fish, which is a non-target organism of its action. 相似文献
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Coelho Maria Paula Mancini Moreira-de-Sousa Cristina de Souza Raphael Bastão Ansoar-Rodríguez Yadira Silva-Zacarin Elaine Cristina Mathias Fontanetti Carmem Silvia 《Environmental science and pollution research international》2017,24(27):22007-22017
Environmental Science and Pollution Research - Large amounts of residues generated by agricultural, urban and industrial activities are dumped daily on the soil. This practice deserves special... 相似文献
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