Genotoxicity in adult residents in mineral coal region—a cross-sectional study

The present study assessed the DNA damage in environmentally exposed volunteers living in seven municipalities in an industrial coal region, through the use of the comet assay with blood cells and the micronucleus test with buccal cells. Blood and buccal smears were collected from 320 male volunteers living in seven cities inserted in a coal region. They were ages of 18 and 50 years and also completed a questionnaire intended to identify factors associated with DNA damage through a Poisson regression analysis. The comet assay detected significant differences in DNA damage in volunteers from different municipalities, and neighboring cities (Pedras Altas, Aceguá, and Hulha Negra) had a higher level of DNA damage in relation to control city. Some of the risk factors associated with identified DNA lesions included residence time and life habits. On the other hand, the micronucleus test did not identify differences between the cities studied, but the regression analysis identified risk factors such as age and life habits (consumption of mate tea and low carbohydrates diet). We conclude that there are differences in the DNA damage of volunteers from different cities of the carboniferous region, but the presence of micronuclei in the oral mucosa does not differ between the same cities. Furthermore, we alert that some related factors may increase the risk of genotoxicity, such as residence location and time, and living and food habits. Finally, we suggest the need for continuous biomonitoring of the population, as well as for investing in health promotion in these vulnerable populations.

     

Alterations in some renal parameters of rats induced by aqueous soil extracts

Soil ingestion can be an important route of exposure to contaminants present in the environment. This study examined the effects of exposure to contaminants in aqueous soil extracts from an industrial urban settlement in renal biochemical parameters of treated rats. Male Wistar rats were gavaged with an aqueous soil extract, from the municipality of Rio Grande, Southern Brazil. After exposure, plasma and urine concentrations and plasma protein were assessed compared to rats treated with aqueous soil from relatively unpolluted site (control soil). There was increase in plasma creatinine and total protein in urine, and a decreased glomerular filtration rate in treated rats compared to control. It is possible that Cd, Cr, As, Cu, Pb, Zn, and Ni analyzed in the soil samples and unidentified components may have provoked the observed changes in renal biochemistry of the exposed rat. This may suggest that exposure to contaminated soils can cause damage to the viscera in mammals and it is of public health importance.     

Blood markers among residents from a coal mining area

Environmental Science and Pollution Research - Coal extraction and processing generate environmental contamination, which has several negative impacts on human health. Hematological and biochemical...     

Toxic effects of the ingestion of water-soluble elements found in soil under the atmospheric influence of an industrial complex

In this study, we investigated the toxic effects of water-soluble elements from a contaminated soil via gavage in a single dose, simulating a geophagy event. The contaminated soil was collected in a field located in an industrial complex, and the control soil was collected in a reference area. Metabolic and behavioral parameters in Wistar male rats were measured after 24 and 96 h of gavage. After 96 h, the major organs were weighed, blood was collected to check hematological parameters, the bone marrow was taken for the micronucleus test, and the liver was used for evaluating the total antioxidant capacity, lipoperoxidation and protein carbonylation. Animals exposed to contaminated soil presented a few significant alterations by comparison with control animals: TBARS and protein carbonyl levels increased, the relative weight of the kidneys increased, metabolic parameters (body weight gain, food intake, water consumption, urine and feces production) depressed and there was behavioral alteration. These findings suggest that soils impacted by atmospheric contaminants can affect the organism physiological status jeopardizing the health of populations living in industrial areas. Finally, this study reassures that ingestion of potentially contaminated soils, even for short periods of time, can cause health risks.     

Distribution of potentially harmful elements in soils around a large coal-fired power plant

An understanding of the spatial distribution and contribution of a power plant to local soil contamination is important for the planning of soil use and prioritizing remedial actions for public safety. Consequently, the aim of this study was to map the spatial distribution of potentially hazardous elements (PHEs; Cu, Pb, Zn, Ni, Cr, Fe, Mn, Cd, As, and Se) in soils around a large (796 MW) coal-fired power plant in Brazil. For the purpose, 33 soil samples were collected in the area within a radius of approximately 17.5 km from the plant and subsequently analyzed for PHEs. The frequency and direction of winds were also obtained from a meteorological station in the region. The sampling area was divided into four quadrants (northwest: N-NW; northeast: N-NE; southeast: S-SE; southwest: S-SW), and there were significant negative correlations between the distance and the concentrations of Se in the S-SE quadrant and As in the S-SW and S-SE quadrants. There were positive correlations between distance from the plant and the concentration of Mn in the N-NE quadrant and the concentration of Cd in the S-SW quadrant. The dominant direction of the winds was N-NE. The indexes used in this study showed low-to-moderate enrichment factor, but detailed analysis of the dominant quadrant of the winds showed a correlation with higher concentrations in the soils closer to the power plant for at least seven of the PHEs analyzed, especially with regard to As. Therefore, we conclude that the distribution of the metalloid As can be used as a marker of the spatial distribution of contamination from the thermoelectric plant, but the dynamics of the other elements suggests that the presence of other sources of contamination may also compromise the quality of local soils.

     

Health impact assessment of air pollution in an area of the largest coal mine in Brazil

Environmental Science and Pollution Research - Coal exploration and burning activities are among the activities with the greatest potential to cause atmospheric pollution due to the combustion...     

Multiple exposure pathways and health risk assessment of selenium for children in a coal mining area

Environmental Science and Pollution Research - Selenium (Se) presents a dual role to human body, harmful or beneficial, depending on its concentration. The exposure to this element has been...