A Strategy for the Evaluation of Sensory and Pulmonary Irritation Due to Chemical Emissions from Indoor Sources

Abstract

Sensory and pulmonary irritation are physiological responses to chemical exposure which result in characteristic, measurable changes in respiratory activity in mice. A standard method has been applied to the estimation of sensory irritation associated with a specific chemical exposure. This method has been correlated with human responses to these chemicals. Symptoms associated with chemical irritants are consistent with complaints due to problems with indoor air quality, which may include eye and upper respiratory tract irritation, headaches, and nausea. A stepwise strategy for assessing the contribution of indoor products to sensory and pulmonary irritation is discussed in the current paper. The strategy includes product emissions testing using dynamic environmental chambers, the selection of suspected irritants for respiratory irritation testing, respiratory irritation testing of individual compounds and representative mixtures using synthesized atmospheres, and the evaluation of test data to determine those compounds which may contribute to sensory and pulmonary irritation in humans. The current strategy is being applied to evaluate carpet system materials and their constituent chemicals.     

Nitrogen use in the United States from 1961-2000 and potential future trends

Nitrogen inputs to the US from human activity doubled between 1961 and 1997, with most of the increase in the 1960s and 1970s. The largest increase was in use of inorganic N fertilizer, but emissions of NOx from fossil-fuel combustion also increased substantially. In 1961, N fixation in agricultural systems was the largest single source of reactive N in the US. By 1997, even though N fixation had increased, fertilizer use and NOx emissions had increased more rapidly and were both larger inputs. In both 1961 and 1997, two thirds of reactive N inputs were denitrified or stored in soils and biota, while one third was exported. The largest export was in riverine flux to coastal oceans, followed by export in food and feeds, and atmospheric advection to the oceans. The consumption of meat protein is a major driver behind N use in agriculture in the US Without change in diet or agricultural practices, fertilizer use will increase over next 30 years, and fluxes to coastal oceans may increase by another 30%. However, substantial reductions are possible.     

美国1961～2000年氮使用量的变化及未来趋势预测

从1961～1997年,因人类活动而输入到美国的氮翻了一番,特别是在上个世纪60年代和70年代,其增长量最大.尽管无机氮肥的使用量增长最大,但矿物燃料燃烧所造成的NOx排放,也有明显的增加.1961年,美国农业生产系统中的生物固氮量是活性氮的最大来源;到了1997年,尽管生物固氮量也有增加,但相比而言,无机氮肥的使用和NOx的排放增加得更快,成为两个最大的氮源.1961～1997年,在输入到美国的活性氯中,有2/3发生了脱氮反应或者是被贮存在土壤与生物群落之中,有1/3输出到境外.在输出到境外的这部分氮中,通过河流流到海洋中的分量最大,其次是通过粮食和饲料出口而到其它国家以及通过大气平流传输到了海洋中.动物性蛋白的消费是美国农业系统中氮使用的主要驱动因子,如果饮食方式或农业生产方式不发生改变,在未来30年的时间里,美国肥料的使用量将继续增长,流向海洋中的氮通量将可能再增长30%,但也有可能出现下降.