排序方式: 共有3条查询结果,搜索用时 15 毫秒
1
1.
R. Ramesh P. Kavitha N. Kanipandian S. Arun R. Thirumurugan P. Subramanian 《Environmental monitoring and assessment》2013,185(7):5873-5881
The incorporation of nanoparticles in industrial and biomedical applications has increased significantly in recent years, yet their hazardous and toxic effects have not been studied extensively. While standard toxicological test methods are generally capable of detecting the toxic effects, the choice of relevant methods for nanomaterials is still discussed. Among the various oxide nanomaterials, silica nanoparticles are widely used in biological applications that include nano-medicine. But studies on adverse effects of silica nanoparticle exposure to fish remain unclear. Therefore, the present study was designed to investigate the oxidative toxic effects of silicon dioxide nanoparticles using fish model. The size of the SiO2 nanoparticles was between 68 and 100 nm which was confirmed by X-ray diffractometer, dynamic light scattering, scanning electron microscope and transmission electron microscope. The zebra fish were exposed to sub-lethal concentrations (5 and 2.5 mg/L) of characterized SiO2 nanoparticles for a period of 7 days. After 7 days, SiO2 nanoparticle-treated fishes were sacrificed, and tissues such as liver, muscle and gill were dissected out for the analysis of antioxidant enzymes and DNA fragmentation. The DNA profiles were analysed in the tissues of zebra fish that treated with SiO2 nanoparticles. Tissues of fish from clean water were used as control, and DNA profiles were analysed. It is found that DNA from control tissues was intact, whereas the tissues treated with SiO2 were all fragmented. SiO2 nanoparticle-mediated antioxidant enzymes activities, such as catalase, superoxide dismutase, glutathione (GSH)-S-transferase, glutathione reductase and GSH, in the tissues of zebra fish were measured. The results revealed that alteration of antioxidant enzymes due to SiO2 nanoparticle can be considered as a biomarker to SiO2-mediated oxidative stress in biological samples. 相似文献
2.
Sridhar Arun Krishnasamy Sekar Rajkumar Manikandan Dinesh Babu Arumugam Manikandan Veeran Srinivasan Ramasamy Thirumurugan 《Environmental science and pollution research international》2021,28(26):33914-33926
Environmental Science and Pollution Research - The epidermal mucus of fish performs diverse functions from prevention of mechanical abrasion to limit pathogen invasions. The current experiment was... 相似文献
3.
Manikandan Dinesh Babu Arumugam Manikandan Veeran Srinivasan Sridhar Arun Krishnasamy Sekar Rajkumar Perumalsamy Balaji Ramasamy Thirumurugan 《Environmental science and pollution research international》2021,28(26):33927-33941
Environmental Science and Pollution Research - Nanotechnology tends to be a swiftly growing field of research that actively influences and inhibits the growth of bacteria/cancer. Noble metal... 相似文献
1