Effects of cimetidine and N-acetylcysteine on paraquat-induced acute lung injury in rats: a preliminary study

Abstract

Lung injury in rats challenged with paraquat at 20?mg kg^?1 body weight was histopathologically evident by inflammation, hemorrhage, and vascular congestion. Increased levels of reactive oxygen species and lipid peroxidation, decreased glutathione content, and lower tissue antioxidant capacity was found. The effects of N-acetylcysteine and cimetidine, a well-known potent inhibitor for organic cation transport, were examined. Lung injury was attenuated by N-acetylcysteine but not by cimetidine. The findings are consistent with the assumption that beneficial effects of N-acetylcysteine administration in paraquat-challenged animals might be linked to its ability for preserving the cellular redox environment and preventing oxidative stress, while cimetidine might even hasten paraquat-induced lung injury. On the other hand, the effects of cimetidine on paraquat-induced lung injury underline the importance of future studies on the role of transporters in this complication.     

Positive environmental effects of the coronavirus 2020 episode: a review

Environment, Development and Sustainability - The outbreak of COVID-19 has made a global catastrophic situation that caused 1,039,406 deaths out of 35,347,404 infections, and it will also cause...     

Acute toxicity of waterborne manganese to Rutilus caspicus (Yakovlev, 1870) – gill histopathology,immune indices,oxidative condition,and saltwater resistance

The acute toxicity of manganese (Mn) in Caspian roach Rutilus caspicus was determined. The 96 h-LC₅₀ was calculated to be 300 (240–360) mg L^?1. Then, fish were exposed for 96 h to 300 (96 h-LC₅₀), 150 (50% of 96 h-LC₅₀), 60 (20% of 96 h-LC₅₀), and 0 (control group) mg L^?1 Mn. Exposure to all Mn concentrations led to fish gill damages, including epithelial lifting, hyperplasia, lamellar fusion, aneurism, and lamellar curling. Also, the fish exposed to all Mn concentrations showed decreased plasma alternative complement and lysozyme activity. Whole body superoxide dismutase, catalase, and malondialdehyde showed significant increases in the Mn-exposed fish which also exhibited lower tolerance to saltwater than the control group.