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In the initiation/promotion assay in rat liver, partial hepatectomy is used to enhance initiation, and a choline-devoid diet as promoter. The induction of carcinogenesis is determined by the focal appearance of gamma glutamyl transpeptidase (GGT) positive hepatocytes. We adopted this assay to diesel exhaust emission by performing a
partial hepatectomy, and exposing the rats to either clean air or diesel exhaust emission. The rats were fed either a choline-devoid or a choline-supplemented diet for three or six months. The animals were sacrificed and liver sections stained for GGT were examined for the presence of foci of GGT(+) hepatocytes. The results indicate that diesel exhaust exposure does not result in a systemic dose of carcinogens sufficient to be detected in the liver foci assay. 相似文献
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Zhang Xiaoxi Shinozuka Machiko Tanaka Yuriko Kanamori Yuko Masui Toshihiko 《Environment, Development and Sustainability》2022,24(4):5614-5640
Environment, Development and Sustainability - Many information and communications technology (ICT) services have become commonplace worldwide and are certain to continue to spread faster than... 相似文献
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