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Quaiser Saqui Mohammad Faisal Abdulrahman A. Alatar Abdulaziz A. Al-Khedhairy Mukhtar Ahme Sabiha M. Ansari Hend A. Alwathnani Mohammad K. Okl Sourabh Dwivedi Javed Musarrat Shelly Praveen Shams T. Khan Rizwan Waha Maqsood A. Siddiqui Javed Ahmad 《环境科学学报(英文版)》2016,28(9):49-62
We have studied the genotoxic and apoptotic potential of ferric oxide nanoparticles(Fe_2O_3-NPs) in Raphanus sativus(radish).Fe_2O_3-NPs retarded the root length and seed germination in radish.Ultrathin sections of treated roots showed subcellular localization of Fe_2O_3-NPs,along with the appearance of damaged mitochondria and excessive vacuolization.Flow cytometric analysis of Fe_2O_3-NPs(1.0 mg/m L) treated groups exhibited 219.5%,161%,120.4% and 161.4% increase in intracellular reactive oxygen species(ROS),mitochondrial membrane potential(ΔΨm),nitric oxide(NO) and Ca2+influx in radish protoplasts.A concentration dependent increase in the antioxidative enzymes glutathione(GSH),catalase(CAT),superoxide dismutase(SOD) and lipid peroxidation(LPO) has been recorded.Comet assay showed a concentration dependent increase in deoxyribonucleic acid(DNA) strand breaks in Fe_2O_3-NPs treated groups.Cell cycle analysis revealed 88.4% of cells in sub-G1 apoptotic phase,suggesting cell death in Fe_2O_3-NPs(2.0 mg/m L) treated group.Taking together,the genotoxicity induced by Fe_2O_3-NPs highlights the importance of environmental risk associated with improper disposal of nanoparticles(NPs) and radish can serve as a good indicator for measuring the phytotoxicity of NPs grown in NP-polluted environment. 相似文献
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Waha Katharina Krummenauer Linda Adams Sophie Aich Valentin Baarsch Florent Coumou Dim Fader Marianela Hoff Holger Jobbins Guy Marcus Rachel Mengel Matthias Otto Ilona M. Perrette Mahé Rocha Marcia Robinson Alexander Schleussner Carl-Friedrich 《Regional Environmental Change》2017,17(6):1623-1638
Regional Environmental Change - The Middle East and North Africa (MENA) region emerges as one of the hot spots for worsening extreme heat, drought and aridity conditions under climate change. A... 相似文献
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