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Enhanced hepatotoxicity induced by repeated exposure to polychlorinated
biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin in combination in male rats
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Yimei Wang Chunfeng Lu Zhiguo Sheng Gang Liu Ze Fu Benzhan Zhu Shuangqing Peng 《环境科学学报(英文版)》2011,23(1):119-124
2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) and polychlorinated biphenyls(PCBs) are among persistent polyhalogenated aromatic hydrocarbons that exist as complex mixtures in the environment worldwide.The present study was attempted to investigate the hepatotoxicity following repeated exposure to TCDD and PCBs in combination in male rats,and to reveal the involvement of potential mechanisms.Male Sprague-Dawley rats were exposed to TCDD(10 μg/kg) and Aroclor 1254(10 mg/kg,a representative mixture of PCBs) alone ... 相似文献
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