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T-2 toxin induces developmental toxicity and apoptosis in zebrafish embryos 总被引:1,自引:0,他引:1
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Guogang Yuan Yimei Wang Xiaoyan Yuan Tingfen Zhang Jun Zhao Liuyu Huang Shuangqing Peng 《环境科学学报(英文版)》2014,26(4):917-925
T-2 toxin is one of the most important trichothecene mycotoxins occurring in various agriculture products. The developmental toxicity of T-2 toxin and the exact mechanism of action at early life stages are not understood precisely. Zebrafish embryos were exposed to different concentrations of the toxin at 4-6 hours post fertilization (hpf) stage of development, and were observed for different developmental toxic effects at 24, 48, 72, and 144 hpf. Exposure to 0.20 Ixmol/L or higher concentrations of T-2 toxin significantly increased the mortality and malformation rate such as tail deformities, cardiovascular defects and behavioral changes in early developmental stages of zebrafish. T-2 toxin exposure resulted in significant increases in reactive oxygen species (ROS) production and cell apoptosis, mainly in the tall areas, as revealed by Acridine Orange staining at 24 hpf. In addition, T-2 toxin-induced severe tail deformities could be attenuated by co-exposure to reduced glutathione (GSH). T-2 toxin and GSH co-exposure induced a significant decrease of ROS production in the embryos. The overall results demonstrate that T-2 toxin is able to produce oxidative stress and induce apoptosis, which are involved in the developmental toxicity of T-2 toxin in zebrafish embryos. 相似文献
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概述了我国履行国际公约淘汰哈龙的整体情况,分析相关管理政策执行现状,指出了我国哈龙管理中存在的问题。根据澳大利亚哈龙回收和再利用管理的经验,提出在中国设立哈龙银行并实行三级管理机制,开发替代技术以及加强回收再利用等哈龙管理建议。 相似文献
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Enhanced hepatotoxicity induced by repeated exposure to polychlorinated
biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin in combination in male rats
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Yimei Wang Chunfeng Lu Zhiguo Sheng Gang Liu Ze Fu Benzhan Zhu Shuangqing Peng 《环境科学学报(英文版)》2011,23(1):119-124
2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) and polychlorinated biphenyls(PCBs) are among persistent polyhalogenated aromatic hydrocarbons that exist as complex mixtures in the environment worldwide.The present study was attempted to investigate the hepatotoxicity following repeated exposure to TCDD and PCBs in combination in male rats,and to reveal the involvement of potential mechanisms.Male Sprague-Dawley rats were exposed to TCDD(10 μg/kg) and Aroclor 1254(10 mg/kg,a representative mixture of PCBs) alone ... 相似文献
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